Detailed view for Tb927.3.1490

Basic information

TDR Targets ID: 16640
Trypanosoma brucei, leucine-rich repeat protein (LRRP), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.0767 | Length (AA): 816 | MW (Da): 89960 | Paralog Number: 13

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13306   Leucine rich repeats (6 copies)
PF13516   Leucine Rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0003674   molecular_function  
GO:0008150   biological_process  
GO:0005575   cellular_component  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126657)

Species Accession Gene Product
Arabidopsis thaliana AT1G15740   leucine-rich repeat-containing protein
Brugia malayi Bm1_13125   ras-binding protein SUR-8
Caenorhabditis elegans CELE_AC7.2   Protein SOC-2, isoform B
Dictyostelium discoideum DDB_G0294094   leucine-rich repeat-containing protein
Drosophila melanogaster Dmel_CG5407   CG5407 gene product from transcript CG5407-RA
Echinococcus granulosus EgrG_000143400   leucine rich repeat and death domain containing protein
Echinococcus granulosus EgrG_000729500   leucine rich repeat protein soc 2
Entamoeba histolytica EHI_167290   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_024640   leucine-rich repeat containing protein
Entamoeba histolytica EHI_081720   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_066620   leucine rich repeat protein, BspA family
Entamoeba histolytica EHI_076850   leucine-rich repeat containing protein
Entamoeba histolytica EHI_050750   leucine rich repeat / protein phosphatase 2C domain containing protein
Entamoeba histolytica EHI_042230   leucine rich repeat / protein phosphatase 2C domain containing protein
Echinococcus multilocularis EmuJ_000141100   leucine rich repeat and death domain containing protein
Echinococcus multilocularis EmuJ_000143400   leucine rich repeat and death domain containing protein
Echinococcus multilocularis EmuJ_000038300   leucine rich repeat protein SHOC 2
Echinococcus multilocularis EmuJ_000729500   leucine rich repeat protein soc 2
Homo sapiens ENSG00000108061   soc-2 suppressor of clear homolog (C. elegans)
Homo sapiens ENSG00000240720   leucine-rich repeats and death domain containing 1
Leishmania braziliensis LbrM.03.0030   hypothetical protein
Leishmania major LmjF.03.0010   hypothetical protein
Loa Loa (eye worm) LOAG_09352   Ras-binding protein SUR-8
Loa Loa (eye worm) LOAG_12528   sur-8-PB
Mus musculus ENSMUSG00000024976   soc-2 (suppressor of clear) homolog (C. elegans)
Mus musculus ENSMUSG00000040367   leucine rich repeats and death domain containing 1
Oryza sativa 4350068   Os11g0213800
Oryza sativa 4346736   Os09g0325700
Oryza sativa 9267951   Os05g0297500
Oryza sativa 4350057   Os11g0211300
Oryza sativa 4329969   Os02g0613200
Oryza sativa 4350060   Os11g0212000
Oryza sativa 4336323   Os04g0503500
Oryza sativa 4325115   Os01g0260500
Oryza sativa 4329870   Os02g0597300
Oryza sativa 4350067   Os11g0213700
Oryza sativa 9267061   Os08g0265300
Schistosoma japonicum Sjp_0111120   Leucine-rich repeat protein SHOC-2, putative
Schistosoma japonicum Sjp_0058620   Leucine-rich repeat and death domain-containing protein LOC401387 homolog, putative
Schistosoma japonicum Sjp_0305880   Leucine-rich repeat protein SHOC-2, putative
Schistosoma mansoni Smp_129120   shoc2
Schistosoma mansoni Smp_108780   hypothetical protein
Schistosoma mansoni Smp_008450   hypothetical protein
Schmidtea mediterranea mk4.000612.04  
Schmidtea mediterranea mk4.007365.00  
Schmidtea mediterranea mk4.003274.00  
Schmidtea mediterranea mk4.000109.02   Leucine-rich repeat protein soc-2
Schmidtea mediterranea mk4.000109.01  
Schmidtea mediterranea mk4.015576.00  
Schmidtea mediterranea mk4.005922.00   Putative shoc2
Schmidtea mediterranea mk4.020734.00  
Schmidtea mediterranea mk4.003196.01  
Schmidtea mediterranea mk4.000550.08  
Trypanosoma brucei gambiense Tbg972.11.1610   T. brucei spp.-specific protein,hypothetical protein, conserved,leucine-rich repeat protein (LRRP),leucine-rich repeat protein (
Trypanosoma brucei gambiense Tbg972.3.1250   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.3.1490   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0448   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0838   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.2.950   paraflagellar rod component, putative
Trypanosoma brucei Tb927.6.130   hypothetical leucine-rich repeat protein 1 (LRRP1)
Trypanosoma brucei Tb927.1.480   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0703   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.1.370   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0602   leucine-rich repeat protein 1 (LRRP1), putative
Trypanosoma brucei Tb927.1.290   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb11.v5.0560   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.11.1510   leucine rich repeat protein, putative
Trypanosoma brucei Tb11.v5.0551   leucine-rich repeat protein (LRRP), putative
Trypanosoma brucei Tb927.2.170   leucine-rich repeat protein 1 (LRRP1), putative
Trichomonas vaginalis TVAG_480940   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_RG_DS113350_7   conserved hypothetical protein
Trichomonas vaginalis TVAG_129560   leucine-rich transmembrane proteins, putative
Trichomonas vaginalis TVAG_148510   protein phosphatase 2C-2, putative
Trichomonas vaginalis TVAG_489945   leucine-rich repeat protein, BspA family
Trichomonas vaginalis TVAG_334930   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_257810   leucine-rich repeat protein, BspA family
Trichomonas vaginalis TVAG_171040   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_093780   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_028660   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_321810   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_093970   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_319030   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_210020   podocan, putative
Trichomonas vaginalis TVAG_416550   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_312980   leucine-rich repeat containing protein, putative
Trichomonas vaginalis TVAG_288800   leucine-rich repeat-containing protein, putative
Trichomonas vaginalis TVAG_168890   protein phosphatase 2C, putative
Trichomonas vaginalis TVAG_358120   protein phosphatase 2C, putative

Essentiality

Tb927.3.1490 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1490 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1490 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.1490 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.1490 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.2.950 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.480 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.480 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.2.690 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.290 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.370 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.370 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_AC7.2 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.3.1490 (Trypanosoma brucei), leucine-rich repeat protein (LRRP), putative
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