Detailed view for Tb927.5.650

Basic information

TDR Targets ID: 16699
Trypanosoma brucei, receptor-type adenylate cyclase GRESAG 4, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 4.9607 | Length (AA): 1281 | MW (Da): 139401 | Paralog Number: 81

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016021   integral to membrane  
GO:0016849   phosphorus-oxygen lyase activity  
GO:0004016   adenylate cyclase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  

Metabolic Pathways

Purine metabolism (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 1FX2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1FX4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126617)

Species Accession Gene Product
Leishmania braziliensis LbrM.17.0110   receptor-type adenylate cyclase, putative
Leishmania braziliensis LbrM.17.0010   receptor-type adenylate cyclase a
Leishmania braziliensis LbrM.17.0120   receptor-type adenylate cyclase b
Leishmania braziliensis LbrM.17.0130   receptor-type adenylate cyclase b
Leishmania braziliensis LbrM.17.0100   receptor-type adenylate cyclase, putative
Leishmania donovani LdBPK_170150.1   receptor-type adenylate cyclase b
Leishmania infantum LinJ.17.0140   receptor-type adenylate cyclase b
Leishmania infantum LinJ.17.0120   receptor-type adenylate cyclase a
Leishmania infantum LinJ.17.0160   receptor-type adenylate cyclase b
Leishmania infantum LinJ.17.0150   receptor-type adenylate cyclase b
Leishmania infantum LinJ.17.0130   receptor-type adenylate cyclase, putative
Leishmania major LmjF.17.0235   receptor-type adenylate cyclase b
Leishmania major LmjF.17.0180   receptor-type adenylate cyclase b
Leishmania major LmjF.17.0237   receptor-type adenylate cyclase b
Leishmania major LmjF.17.0230   receptor-type adenylate cyclase b
Leishmania major LmjF.17.0190   receptor-type adenylate cyclase, putative
Leishmania major LmjF.17.0200   receptor-type adenylate cyclase a
Leishmania mexicana LmxM.17.0200   receptor-type adenylate cyclase a
Leishmania mexicana LmxM.17.0190partial  
Leishmania mexicana LmxM.17.0235   receptor-type adenylate cyclase b
Leishmania mexicana LmxM.17.0237   receptor-type adenylate cyclase b
Leishmania mexicana LmxM.17.0190   receptor-type adenylate cyclase, putative
Leishmania mexicana LmxM.17.0191   receptor-type adenylate cyclase a
Mycobacterium tuberculosis Rv1120c   Conserved hypothetical protein
Mycobacterium tuberculosis Rv0891c   Possible transcriptional regulatory protein
Mycobacterium ulcerans MUL_0150   hypothetical protein
Schistosoma mansoni Smp_112590   hypothetical protein
Schistosoma mansoni Smp_113470   hypothetical protein
Schistosoma mansoni Smp_186540   receptor-type adenylate cyclase
Schistosoma mansoni Smp_113460   receptor-type adenylate cyclase
Schmidtea mediterranea mk4.013108.00  
Trypanosoma brucei gambiense Tbg972.10.19920   expression site-associated gene (ESAG)
Trypanosoma brucei gambiense Tbg972.11.19250   expression site-associated gene (ESAG) protein, putative,expression site-associated gene 4 (ESAG4) protein, putative,receptor-ty
Trypanosoma brucei gambiense Tbg972.11.1580   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.6.500  
Trypanosoma brucei gambiense Tbg972.7.7020   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.4520   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.4530   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.5.220   receptor-type adenylate cyclase GRESAG 4, putative,adenylyl cyclase, putative,ATP pyrophosphate-lyase, putative
Trypanosoma brucei gambiense Tbg972.7.7030   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.8.8230   receptor-type adenylate cyclase, GRESAG
Trypanosoma brucei gambiense Tbg972.11.6690   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.8.8240   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.7.7010   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.4.3960   receptor-type adenylate cyclase GRESAG, putative
Trypanosoma brucei gambiense Tbg972.4.4570  
Trypanosoma brucei gambiense Tbg972.10.15760   receptor-type adenylate cyclase GRESAG 4, putative,ESAG 4 (expression site-associated gene 4) protein, putative
Trypanosoma brucei gambiense Tbg972.6.510   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.4510   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.8.8700   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.10.19590   receptor-type adenylate cyclase GRESAG 4, putative,expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei gambiense Tbg972.6.490   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.5.890   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.11.10   expression site-associated gene (ESAG)
Trypanosoma brucei gambiense Tbg972.5.20   receptor-type adenylate cyclase GRESAG, putative
Trypanosoma brucei gambiense Tbg972.6.110   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.10.2990   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.4540   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.10.19830   expression site-associated gene 4 (ESAG4) protein, putative,expression site-associated gene (ESAG) protein, putative,receptor-ty
Trypanosoma brucei gambiense Tbg972.4.3980   receptor-type adenylate cyclase GRESAG, putative
Trypanosoma brucei gambiense Tbg972.7.7000   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.4.3790   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.3990   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.11.15330   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.7.8760   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.5.210   receptor-type adenylate cyclase GRESAG 4, putative,adenylyl cyclase, putative
Trypanosoma brucei gambiense Tbg972.4.4580   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.5.1970   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.4.3940   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.4.3970   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.5.6140   receptor-type adenylate cyclase GRESAG 4, putative,adenylyl cyclase, putative,ATP pyrophosphate-lyase, putative
Trypanosoma brucei gambiense Tbg972.8.7870   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei gambiense Tbg972.8.8250  
Trypanosoma brucei gambiense Tbg972.9.9790   expression site-associated gene 4 (ESAG4) protein, putative,receptor-type adenylate cyclase, putative
Trypanosoma brucei gambiense Tbg972.4.4550   receptor-type adenylate cyclase GRESAG 4, putative,receptor-type adenylate cyclase GRESAG 4.4B
Trypanosoma brucei gambiense Tbg972.4.3950   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.11.1570   receptor-type adenylate cyclase GRESAG
Trypanosoma brucei gambiense Tbg972.4.4560  
Trypanosoma brucei Tb927.7.6040   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.8.8360   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb09.v4.0009   receptor-type adenylate cyclase, putative
Trypanosoma brucei Tb927.6.770   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.330   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0484   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.8.7860   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.3870   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.1015   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei Tb927.7.7520   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.10.16000   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei Tb927.10.13040   procyclic-enriched flagellar receptor adenylate cyclase 4
Trypanosoma brucei Tb11.v5.0576   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.4460   adenylyl cyclase
Trypanosoma brucei Tb927.8.7900   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.8.7590   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.11.18690   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei Tb927.11.150   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.10.16190   procyclic-enriched flagellar receptor adenylate cyclase 2
Trypanosoma brucei Tb11.v5.0431   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.7.6050   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0424   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb05.5K5.180   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.180   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.650   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.9.15660   procyclic-enriched flagellar receptor adenylate cyclase 6
Trypanosoma brucei Tb927.5.1450   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0864   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0379   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0784   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.7.6080   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0821   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.190   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0281   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.310   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.10.2430   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0209   Adenylate and Guanylate cyclase catalytic domain containing protein, putative
Trypanosoma brucei Tb927.11.17040   procyclic-enriched flagellar receptor adenylate cyclase 1
Trypanosoma brucei Tb927.4.3880   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.330   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.8.7890   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.800   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.4410   adenylyl cyclase
Trypanosoma brucei Tb927.7.7530   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.4450   adenylyl cyclase
Trypanosoma brucei Tb927.6.300   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.760   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.3860   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.4430   adenylyl cyclase
Trypanosoma brucei Tb927.11.5940   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0425   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.285b   expression site associated gene (ESAG) 4 protein, putative
Trypanosoma brucei Tb11.v5.0380   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.6.280   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.4540   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.3750   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0654   receptor-type adenylate cyclase, putative
Trypanosoma brucei Tb927.4.4470   adenylyl cyclase
Trypanosoma brucei Tb11.v5.0830   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0470   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.780   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.200   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.4550   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.11.140   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei Tb11.v5.0456   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0217   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.8.7940   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.7.7470   procyclic-enriched flagellar receptor adenylate cyclase 3
Trypanosoma brucei Tb927.8.7930   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.7.6070   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.430   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.4.4440   adenylyl cyclase
Trypanosoma brucei Tb927.8.7920   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.7.6060   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0429   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.5.320   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.6.790   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb927.11.1480   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb427tmp.03.0990   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma brucei Tb927.11.13740   procyclic-enriched flagellar receptor adenylate cyclase 5
Trypanosoma brucei Tb05.5K5.190   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma brucei Tb11.v5.0865   receptor-type adenylate cyclase GRESAG 4, putative
Trypanosoma congolense TcIL3000_4_3430   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_39390   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_53960   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_29930   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_03100   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_33850   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_22990   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_23420   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_09250   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_26950   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_16460   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_23050   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_14050   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_16450   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_19050   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_16440   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_52990   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000.11.14040   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_59360   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_45460   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_21630   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_37000   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_10_2060   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_36330   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_02830   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_60800   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_8_7980   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_48190   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_45440   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_19060   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_29940   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000.11.16970   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_58990   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_13600   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_39890   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_27400   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_51710   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_59890   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_59590   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_4_3420   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_09840   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_15380   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_38650   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_7_6140   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_31740   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_35890   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_37820   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000_0_30030   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma congolense TcIL3000.11.10   expression site-associated gene 4 (ESAG4) protein, putative
Trypanosoma cruzi TcCLB.506717.20   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.510581.20   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.507965.10   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.509449.10   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.511895.10   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.506355.20   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.509539.20   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.511705.10   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.509267.3   receptor-type adenylate cyclase, putative
Trypanosoma cruzi TcCLB.511043.60   receptor-type adenylate cyclase, putative

Essentiality

Tb927.5.650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1140 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Adenylate Cyclase (4.6.1.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

  • Reagent:
  • Target Type Source Notes
    Tb927.5.650 cloned gene BRENDA A gene with this EC number or name or sequence has been cloned from Trypanosoma brucei ( 1 )

Bibliographic References

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Gene identifier Tb927.5.650 (Trypanosoma brucei), receptor-type adenylate cyclase GRESAG 4, putative
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