pI: 7.0717 |
Length (AA): 1274 |
MW (Da): 143817 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
299 | 456 | 5cwh (A) | 4 | 159 | 14.00 | 0.46 | 0.06 | 0.28247 | -0.9 |
310 | 414 | 5jsn (B) | 8 | 116 | 16.00 | 0.56 | 0.66 | 0.281227 | -0.59 |
359 | 1317 | 4boc (A) | 295 | 1230 | 26.00 | 0 | 1 | 0.87867 | 0.26 |
396 | 576 | 4uos (A) | 3 | 183 | 9.00 | 0.000021 | 0.02 | 0.272934 | -1.07 |
476 | 1317 | 3e2e (A) | 8 | 883 | 22.00 | 0 | 1 | 0.767832 | 0.38 |
736 | 1317 | 4rnp (A) | 289 | 883 | 29.00 | 0 | 1 | 0.558413 | 1.19 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127975)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G15700 | DNA-directed RNA polymerase 2 |
Arabidopsis thaliana | AT1G68990 | DNA-directed RNA polymerase 1, mitochondrial |
Arabidopsis thaliana | AT2G24120 | DNA-directed RNA polymerase 3 |
Babesia bovis | BBOV_III002990 | DNA-dependent RNA polymerase, putative |
Brugia malayi | Bm1_24475 | DNA-dependent RNA polymerase family protein |
Candida albicans | CaO19.13462 | Mitochondrial RNA polymerase |
Candida albicans | CaO19.6041 | Mitochondrial RNA polymerase |
Caenorhabditis elegans | CELE_Y105E8A.23 | Protein Y105E8A.23, isoform A |
Dictyostelium discoideum | DDB_G0267416 | DNA-dependent RNA polymerase |
Drosophila melanogaster | Dmel_CG4644 | mitochondrial RNA polymerase |
Echinococcus granulosus | EgrG_000150100 | t3:t7 bacteriophage mitochodrial |
Echinococcus multilocularis | EmuJ_000150100 | t3:t7 bacteriophage mitochodrial |
Homo sapiens | ENSG00000099821 | polymerase (RNA) mitochondrial (DNA directed) |
Leishmania braziliensis | LbrM.24.1170 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania donovani | LdBPK_241180.1 | DNA-directed RNA polymerase, mitochondrial |
Leishmania infantum | LinJ.24.1180 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania major | LmjF.24.1150 | mitochondrial DNA-directed RNA polymerase, putative |
Leishmania mexicana | LmxM.24.1150 | mitochondrial DNA-directed RNA polymerase, putative |
Loa Loa (eye worm) | LOAG_10422 | DNA-dependent RNA polymerase |
Mus musculus | ENSMUSG00000020329 | polymerase (RNA) mitochondrial (DNA directed) |
Neospora caninum | NCLIV_063080 | DNA-directed RNA polymerase (EC 2.7.7.6), related |
Oryza sativa | 4346491 | Os09g0246200 |
Oryza sativa | 4341695 | Os06g0652000 |
Plasmodium berghei | PBANKA_0923000 | DNA-directed RNA polymerase, putative |
Plasmodium falciparum | PF3D7_1125300 | DNA-directed RNA polymerase |
Plasmodium knowlesi | PKNH_0923200 | DNA-directed RNA polymerase, putative |
Plasmodium vivax | PVX_091885 | DNA-dependent RNA polymerase, putative |
Plasmodium yoelii | PY06560 | DNA-dependent RNA polymerase-related |
Plasmodium yoelii | PY06559 | DNA-dependent RNA polymerase-related |
Saccharomyces cerevisiae | YFL036W | Rpo41p |
Schistosoma japonicum | Sjp_0010530 | ko:K00960 DNA-directed RNA polymerase [EC2.7.7.6], putative |
Schistosoma mansoni | Smp_148720 | t3/t7 bacteriophage-related mitochodrial DNA-directed rna polymerase |
Schmidtea mediterranea | mk4.000959.08 | |
Schmidtea mediterranea | mk4.000959.09 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.6520 | mitochondrial DNA-directed RNA polymerase, putative |
Trypanosoma brucei | Tb927.11.5780 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma congolense | TcIL3000.11.6160 | DNA-directed RNA polymerase, mitochondrial |
Trypanosoma congolense | TcIL3000_0_56560 | mitochondrial DNA-directed RNA polymerase |
Trypanosoma cruzi | TcCLB.508641.260 | DNA-directed RNA polymerase, mitochondrial |
Toxoplasma gondii | TGME49_246060 | DNA-dependent RNA polymerase |
Theileria parva | TP01_0975 | DNA-directed RNA polymerase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.3530 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.3530 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.3530 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.3530 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y105E8A.23 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_246060 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.