Detailed view for PF3D7_1120100

Basic information

TDR Targets ID: 1677
Plasmodium falciparum, phosphoglycerate mutase, putative

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.4069 | Length (AA): 250 | MW (Da): 28770 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00300   Histidine phosphatase superfamily (branch 1)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016868   intramolecular transferase activity, phosphotransferases  
GO:0005829   cytosol  
GO:0004619   phosphoglycerate mutase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  
GO:0006096   glycolysis  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 241 1xq9 (A) 9 249 99.99 0 1 2.18 -1.67
3 250 1bif () 248 458 23.00 0 1 1.07 0.05
1 231 3kkk (B) 1 231 99.99 0 1 2.1842 -1.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1XQ9:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3KKK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127491)

Species Accession Gene Product
Arabidopsis thaliana AT1G78050   phosphoglycerate/bisphosphoglycerate mutase
Arabidopsis thaliana AT1G22170   phosphoglycerate mutase family protein
Babesia bovis BBOV_III007860   phosphoglycerate mutase 1 family protein
Candida albicans CaO19.8522   phosphoglycerate mutase similar to S. cerevisiae GPM1 (YKL152C)
Candida albicans CaO19.903   phosphoglycerate mutase similar to S. cerevisiae GPM1 (YKL152C)
Cryptosporidium hominis Chro.70471   phosphoglycerate mutase
Cryptosporidium parvum cgd7_4270   glycolytic phosphoglycerate mutase
Chlamydia trachomatis CT_722   2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Dictyostelium discoideum DDB_G0285311   phosphoglycerate mutase
Drosophila melanogaster Dmel_CG1721   Phosphoglyceromutase
Drosophila melanogaster Dmel_CG17645   CG17645 gene product from transcript CG17645-RA
Escherichia coli b0755   phosphoglyceromutase 1
Echinococcus granulosus EgrG_000907900   phosphoglycerate mutase
Echinococcus granulosus EgrG_000799500   phosphoglycerate mutase
Echinococcus granulosus EgrG_000907800   phosphoglycerate mutase
Echinococcus multilocularis EmuJ_000907800   phosphoglycerate mutase
Echinococcus multilocularis EmuJ_000907900   phosphoglycerate mutase
Echinococcus multilocularis EmuJ_000799500   phosphoglycerate mutase
Homo sapiens ENSG00000164708   phosphoglycerate mutase 2 (muscle)
Homo sapiens ENSG00000171314   phosphoglycerate mutase 1 (brain)
Homo sapiens ENSG00000172331   2,3-bisphosphoglycerate mutase
Mycobacterium leprae ML2441c   PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)
Mus musculus ENSMUSG00000011752   phosphoglycerate mutase 1
Mus musculus ENSMUSG00000020475   phosphoglycerate mutase 2
Mus musculus ENSMUSG00000038871   2,3-bisphosphoglycerate mutase
Mycobacterium tuberculosis Rv0489   Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Mycobacterium ulcerans MUL_4558   phosphoglyceromutase
Neospora caninum NCLIV_006170   Phosphoglycerate mutase, related
Oryza sativa 4330747   Os02g0751800
Plasmodium berghei PBANKA_0928100   phosphoglycerate mutase, putative
Plasmodium falciparum PF3D7_1120100   phosphoglycerate mutase, putative
Plasmodium knowlesi PKNH_0917800   phosphoglycerate mutase, putative
Plasmodium vivax PVX_091640   phosphoglycerate mutase, putative
Saccharomyces cerevisiae YKL152C   phosphoglycerate mutase GPM1
Schistosoma japonicum Sjp_0304750   ko:K01834 phosphoglycerate mutase [EC5.4.2.1], putative
Schistosoma mansoni Smp_096760   phosphoglycerate mutase
Schmidtea mediterranea mk4.066543.00   Bisphosphoglycerate mutase
Schmidtea mediterranea mk4.000988.02   Bisphosphoglycerate mutase
Schmidtea mediterranea mk4.038083.04   Bisphosphoglycerate mutase
Toxoplasma gondii TGME49_297060   phosphoglycerate mutase PGMII
Treponema pallidum TP0168   phosphoglyceromutase
Theileria parva TP04_0690   phosphoglycerate mutase I, putative
Trichomonas vaginalis TVAG_209020   phosphoglycerate mutase, putative
Trichomonas vaginalis TVAG_212740   phosphoglycerate mutase, putative
Trichomonas vaginalis TVAG_113710   phosphoglycerate mutase, putative

Essentiality

PF3D7_1120100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0755 Escherichia coli non-essential goodall
YKL152C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0928100 Plasmodium berghei Essential plasmo
TGME49_297060 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphoglycerate mutase 1 (brain) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for Phosphoglycerate Mutase (5.4.2.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

  • Pfal005984AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal005984; Recombinant protein: full-length; Source: P falciparum; phosphoglycerate mutase, putative ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1120100 (Plasmodium falciparum), phosphoglycerate mutase, putative
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