Detailed view for Tb11.v5.0337

Basic information

TDR Targets ID: 16875
Trypanosoma brucei, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.1751 | Length (AA): 1231 | MW (Da): 138775 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130265)

Species Accession Gene Product
Brugia malayi Bm1_38365   WD-repeat protein 10
Caenorhabditis elegans CELE_F23B2.4   Protein DAF-10
Drosophila melanogaster Dmel_CG7161   Outer segment 1
Echinococcus granulosus EgrG_000798000   intraflagellar transport protein 122
Echinococcus granulosus EgrG_000798100   intraflagellar transport protein 122
Echinococcus multilocularis EmuJ_000798100   intraflagellar transport protein 122
Echinococcus multilocularis EmuJ_000798000   intraflagellar transport protein 122
Giardia lamblia GL50803_16547   IFT complex A
Homo sapiens 101927266   intraflagellar transport protein 122 homolog
Homo sapiens ENSG00000163913   intraflagellar transport 122
Leishmania braziliensis LbrM.35.1120   hypothetical protein, conserved,predicted WD40 repeat protein
Leishmania donovani LdBPK_361060.1   intraflagellar transport protein 122, putative
Leishmania infantum LinJ.36.1060   hypothetical protein, conserved,predicted WD40 repeat protein
Leishmania major LmjF.36.1000   hypothetical protein, conserved,predicted WD40 repeat protein
Leishmania mexicana LmxM.36.1000   hypothetical protein, conserved,predicted WD40 repeat protein
Loa Loa (eye worm) LOAG_12501   WD-repeat protein 10
Loa Loa (eye worm) LOAG_07624   WD repeat domain 10
Loa Loa (eye worm) LOAG_06362   hypothetical protein
Mus musculus ENSMUSG00000030323   intraflagellar transport 122
Neospora caninum NCLIV_061930   WD-repeat protein, putative
Schistosoma japonicum Sjp_0130390   Conserved hypothetical protein
Schistosoma japonicum Sjp_0090390   Intraflagellar transport protein 122 homolog, putative
Schistosoma japonicum Sjp_0200980   IPR008139,Saposin B;IPR011001,Saposin-like,domain-containing
Schistosoma japonicum Sjp_0075120   Intraflagellar transport protein 122 homolog, putative
Schistosoma japonicum Sjp_0111230   Intraflagellar transport protein 122 homolog, putative
Schistosoma mansoni Smp_194900   hypothetical protein
Schmidtea mediterranea mk4.000540.10   Intraflagellar transport protein 122 homolog
Schmidtea mediterranea mk4.002096.00  
Trypanosoma brucei gambiense Tbg972.10.6580   hypothetical protein, conserved,predicted WD40 protein
Trypanosoma brucei Tb11.v5.0337   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_4530   intraflagellar transport protein 122, putative
Trypanosoma cruzi TcCLB.506679.160   intraflagellar transport protein 122, putative
Toxoplasma gondii TGME49_218290   WD domain, G-beta repeat-containing protein
Trichomonas vaginalis TVAG_208590   WD repeat domain, putative

Essentiality

Tb11.v5.0337 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5380 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5380 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5380 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5380 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_218290 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb11.v5.0337 (Trypanosoma brucei), hypothetical protein, conserved
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