Detailed view for Tb927.11.840

Basic information

TDR Targets ID: 16948
Trypanosoma brucei, sodium/hydrogen exchanger, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.8851 | Length (AA): 801 | MW (Da): 86654 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 15

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0015299   solute:hydrogen antiporter activity  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128860)

Species Accession Gene Product
Caenorhabditis elegans CELE_F41E7.1   Protein F41E7.1
Caenorhabditis elegans CELE_F57G8.5   Protein F57G8.5
Caenorhabditis elegans CELE_F41E7.2   Protein F41E7.2
Drosophila melanogaster Dmel_CG10806   Na[+]/H[+] hydrogen antiporter 1
Drosophila melanogaster Dmel_CG43442   Na[+]/H[+] hydrogen antiporter 2
Echinococcus granulosus EgrG_000546600   mitochondrial sodium:hydrogen exchanger
Echinococcus granulosus EgrG_000546700   mitochondrial sodium:hydrogen exchanger 9B2
Echinococcus granulosus EgrG_000546500   mitochondrial sodium:hydrogen exchanger
Echinococcus multilocularis EmuJ_000546600   mitochondrial sodium:hydrogen exchanger
Echinococcus multilocularis EmuJ_000546700   mitochondrial sodium:hydrogen exchanger 9B2
Echinococcus multilocularis EmuJ_000546500   mitochondrial sodium:hydrogen exchanger
Homo sapiens ENSG00000164038   solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Homo sapiens 102723912   sodium/hydrogen exchanger 9B1-like
Homo sapiens ENSG00000164037   solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
Homo sapiens 101929373   sodium/hydrogen exchanger 9B1-like
Leishmania braziliensis LbrM.14.0960   hypothetical protein, conserved
Leishmania donovani LdBPK_141040.1   sodium/hydrogen exchanger, putative
Leishmania infantum LinJ.14.1040   hypothetical protein, conserved
Leishmania major LmjF.14.0980   hypothetical protein, conserved
Leishmania mexicana LmxM.14.0980   hypothetical protein, conserved
Mus musculus ENSMUSG00000050150   solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
Mus musculus ENSMUSG00000037994   solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Onchocerca volvulus OVOC4415  
Schistosoma japonicum Sjp_0095900   Sodium/hydrogen exchanger-like domain-containing protein 1, putative
Schistosoma mansoni Smp_175980   hypothetical protein
Trypanosoma brucei gambiense Tbg972.11.880   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.840   sodium/hydrogen exchanger, putative
Trypanosoma congolense TcIL3000_5_2370   sodium/hydrogen exchanger, putative
Trypanosoma congolense TcIL3000_0_07180   sodium/hydrogen exchanger, putative
Trypanosoma cruzi TcCLB.511303.160   sodium/hydrogen exchanger, putative
Trypanosoma cruzi TcCLB.511761.50   sodium/hydrogen exchanger, putative

Essentiality

Tb927.11.840 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.03.0300 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.03.0300 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.03.0300 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.03.0300 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.840 (Trypanosoma brucei), sodium/hydrogen exchanger, putative
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