pI: 6.432 |
Length (AA): 366 |
MW (Da): 39937 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
23 | 84 | 5l87 (A) | 5 | 66 | 99.99 | 0 | 1 | 1.5702 | -3.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129337)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G62810 | peroxin 14 |
Brugia malayi | Bm1_07925 | peroxisomal membrane anchor protein |
Candida albicans | CaO19.9371 | similar to P. pastoris PEX14 (AF200421) and to S. cerevisiae PEX14 (YGL153W) peroxisomal peripheral membrane protein (peroxin) |
Candida albicans | CaO19.1805 | similar to P. pastoris PEX14 (AF200421) and to S. cerevisiae PEX14 (YGL153W) peroxisomal peripheral membrane protein (peroxin) |
Caenorhabditis elegans | CELE_R07H5.1 | Protein PRX-14 |
Drosophila melanogaster | Dmel_CG4289 | Peroxin 14 |
Homo sapiens | ENSG00000142655 | peroxisomal biogenesis factor 14 |
Leishmania braziliensis | LbrM.33.0900 | peroxin 14, putative |
Leishmania donovani | LdBPK_212210.1 | peroxin 14, putative |
Leishmania infantum | LinJ.21.2210 | peroxin 14, putative |
Leishmania major | LmjF.21.1840 | peroxin 14, putative |
Leishmania mexicana | LmxM.21.1840 | peroxin 14, putative |
Loa Loa (eye worm) | LOAG_09944 | hypothetical protein |
Mus musculus | ENSMUSG00000028975 | peroxisomal biogenesis factor 14 |
Oryza sativa | 9268894 | Os01g0107000 |
Oryza sativa | 4337525 | Os05g0101200 |
Saccharomyces cerevisiae | YGL153W | Pex14p |
Trypanosoma brucei gambiense | Tbg972.10.150 | peroxin 14, putative |
Trypanosoma brucei | Tb927.10.240 | peroxin 14, putative |
Trypanosoma congolense | TcIL3000_10_100 | peroxin 14, putative |
Trypanosoma cruzi | TcCLB.511145.40 | peroxin 14, putative |
Trypanosoma cruzi | TcCLB.504069.50 | peroxin 14, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.240 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.240 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.240 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.240 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_R07H5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R07H5.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R07H5.1 | Caenorhabditis elegans | slow growth | wormbase |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
10 literature references were collected for this gene.