pI: 4.6415 |
Length (AA): 422 |
MW (Da): 46523 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 37 | 3aih (A) | 191 | 226 | 39.00 | 0.79 | 0.01 | 0.394908 | 0.73 |
63 | 299 | 1cb0 (A) | 17 | 257 | 14.00 | 0 | 0.91 | 0.629911 | 0.47 |
89 | 359 | 5jqs (A) | 111 | 364 | 31.00 | 0 | 1 | 0.85448 | 0.19 |
236 | 404 | 5jbd (A) | 1414 | 1566 | 28.00 | 0.48 | 0.2 | 0.245074 | 2.27 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128472)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G11860 | hypothetical protein |
Arabidopsis thaliana | AT4G22960 | hypothetical protein |
Babesia bovis | BBOV_II005380 | hypothetical protein |
Brugia malayi | Bm1_39690 | hypothetical protein |
Candida albicans | CaO19.3615 | similar to S. cerevisiae YPL191C |
Candida albicans | CaO19.11098 | similar to S. cerevisiae YPL191C |
Caenorhabditis elegans | CELE_Y55F3AM.9 | Protein Y55F3AM.9 |
Dictyostelium discoideum | DDB_G0281445 | DUF544 family protein |
Dictyostelium discoideum | DDB_G0269770 | DUF544 family protein |
Echinococcus granulosus | EgrG_000900800 | protein FAM63A |
Echinococcus multilocularis | EmuJ_000900800 | protein FAM63A |
Homo sapiens | ENSG00000143409 | family with sequence similarity 63, member A |
Homo sapiens | ENSG00000128923 | family with sequence similarity 63, member B |
Loa Loa (eye worm) | LOAG_08127 | hypothetical protein |
Loa Loa (eye worm) | LOAG_16234 | hypothetical protein |
Mus musculus | ENSMUSG00000042444 | family with sequence similarity 63, member B |
Mus musculus | ENSMUSG00000038712 | family with sequence similarity 63, member A |
Neospora caninum | NCLIV_002350 | hypothetical protein |
Oryza sativa | 4342044 | Os06g0712400 |
Oryza sativa | 4342094 | Os06g0721600 |
Onchocerca volvulus | OVOC5059 |
|
Plasmodium berghei | PBANKA_1417600 | conserved protein, unknown function |
Plasmodium falciparum | PF3D7_1319100 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_1419900 | conserved protein, unknown function |
Plasmodium vivax | PVX_122770 | conserved protein, unknown function |
Plasmodium yoelii | PY03275 | hypothetical protein |
Saccharomyces cerevisiae | YGL082W | hypothetical protein |
Saccharomyces cerevisiae | YPL191C | hypothetical protein |
Schistosoma japonicum | Sjp_0091350 | IPR007518,Protein of unknown function DUF544,domain-containing |
Schistosoma japonicum | Sjp_0034890 | similar to Uncharacterized protein YPL191C, putative |
Schistosoma mansoni | Smp_042990.2 | hypothetical protein |
Schistosoma mansoni | Smp_042990.1 | hypothetical protein |
Schmidtea mediterranea | mk4.021421.00 | |
Schmidtea mediterranea | mk4.022214.01 | |
Trypanosoma brucei gambiense | Tbg972.6.4190 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.6.4380 | Protein of unknown function (DUF544), putative |
Trypanosoma congolense | TcIL3000_6_3800 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.509167.200 | Protein of unknown function (DUF544), putative |
Trypanosoma cruzi | TcCLB.509065.170 | Protein of unknown function (DUF544), putative |
Toxoplasma gondii | TGME49_295400 | hypothetical protein |
Theileria parva | TP02_0489 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4380 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4380 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4380 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4380 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_295400 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.