pI: 9.1527 |
Length (AA): 368 |
MW (Da): 41268 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 367 | 4a9a (A) | 3 | 369 | 61.00 | 0 | 1 | 1.73147 | -0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127528)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G39520 | developmentally regulated G-protein |
Babesia bovis | BBOV_IV004700 | developmentally regulated GTP-binding protein 1, putative |
Brugia malayi | Bm1_45105 | Developmentally regulated GTP-binding protein 1, putative |
Candida albicans | CaO19.12549 | predicted GTPase similar to S. cerevisiae FUN11 (YAL036C) |
Candida albicans | CaO19.5083 | predicted GTPase similar to S. cerevisiae FUN11 (YAL036C) |
Caenorhabditis elegans | CELE_T28D6.6 | Protein T28D6.6, isoform A |
Caenorhabditis elegans | CELE_T28D6.6a | Protein T28D6.6, isoform B |
Cryptosporidium hominis | Chro.30404 | GTP-binding-like protein |
Cryptosporidium parvum | cgd3_3580 | DRG-like OBG family GTpase fused to an RNA binding domain TGS domain, Fun11p |
Dictyostelium discoideum | DDB_G0289317 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8340 | upstream of RpIII128 |
Echinococcus granulosus | EgrG_000250600 | developmentally regulated gtp binding protein 1 |
Entamoeba histolytica | EHI_058460 | GTP-binding protein, putative |
Echinococcus multilocularis | EmuJ_000250600 | developmentally regulated gtp binding protein 1 |
Giardia lamblia | GL50803_16200 | Developmentally regulated GTP-binding protein 1 |
Homo sapiens | ENSG00000185721 | developmentally regulated GTP binding protein 1 |
Leishmania braziliensis | LbrM.35.2490 | developmentally regulated GTP-binding protein 1, putative |
Leishmania donovani | LdBPK_362380.1 | developmentally regulated GTP-binding protein 1, putative |
Leishmania infantum | LinJ.36.2380 | developmentally regulated GTP-binding protein 1, putative |
Leishmania major | LmjF.36.2250 | developmentally regulated GTP-binding protein 1, putative |
Leishmania mexicana | LmxM.36.2250 | developmentally regulated GTP-binding protein 1, putative |
Loa Loa (eye worm) | LOAG_11406 | developmentally regulated GTP-binding protein 1 |
Loa Loa (eye worm) | LOAG_01268 | developmentally regulated GTP binding protein 1 |
Mus musculus | ENSMUSG00000020457 | developmentally regulated GTP binding protein 1 |
Neospora caninum | NCLIV_018880 | GTP-binding protein 1, related |
Oryza sativa | 4343980 | Os07g0627800 |
Plasmodium berghei | PBANKA_1239200 | ribosome-interacting GTPase 1, putative |
Plasmodium falciparum | PF3D7_0524400 | ribosome-interacting GTPase 1, putative |
Plasmodium knowlesi | PKNH_1008500 | ribosome-interacting GTPase 1, putative |
Plasmodium vivax | PVX_196290 | unspecified product |
Plasmodium vivax | PVX_222290 | unspecified product |
Plasmodium vivax | PVX_080030 | developmentally regulated GTP-binding protein 1, putative |
Plasmodium yoelii | PY06396 | GTP-binding-like protein |
Saccharomyces cerevisiae | YAL036C | Rbg1p |
Schistosoma japonicum | Sjp_0052790 | ko:K06944 similar to developmentally regulated GTP binding protein 1, putative |
Schistosoma mansoni | Smp_173180.1 | developmentally regulated GTP-binding protein 1 (drg 1) |
Schistosoma mansoni | Smp_173180.2 | developmentally regulated GTP-binding protein 1 (drg 1) |
Schmidtea mediterranea | mk4.001187.03 | Developmentally-regulated GTP-binding protein 1 |
Trypanosoma brucei gambiense | Tbg972.10.8300 | developmentally regulated GTP-binding protein, putative |
Trypanosoma brucei | Tb927.10.6800 | developmentally regulated GTP-binding protein, putative |
Trypanosoma cruzi | TcCLB.510187.160 | developmentally regulated GTP-binding protein, putative |
Toxoplasma gondii | TGME49_244310 | GTP-binding protein |
Theileria parva | TP01_0279 | developmentally regulated GTP-binding protein 1, putative |
Trichomonas vaginalis | TVAG_327110 | GTP-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6800 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6800 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6800 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.6800 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T28D6.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T28D6.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T28D6.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T28D6.6 | Caenorhabditis elegans | sterile | wormbase |
TGME49_244310 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.