pI: 7.1666 |
Length (AA): 1199 |
MW (Da): 133900 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129495)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.13595 | Vacuolar acid trehalase (alpha, alpha-trehalase) |
Candida albicans | CaO19.6214 | Vacuolar acid trehalase (alpha, alpha-trehalase) |
Dictyostelium discoideum | DDB_G0287109 | acid trehalase-like protein 1 |
Drosophila melanogaster | Dmel_CG16965 | CG16965 gene product from transcript CG16965-RC |
Escherichia coli | b1316 | putative family 65 glycosyl hydrolase |
Homo sapiens | ENSG00000142102 | ATH1, acid trehalase-like 1 (yeast) |
Leishmania braziliensis | LbrM.35.5490 | glycosyl hydrolase, putative |
Leishmania donovani | LdBPK_365470.1 | glycosyl hydrolase, putative |
Leishmania infantum | LinJ.36.5470 | glycosyl hydrolase, putative |
Leishmania major | LmjF.36.5240 | glycosyl hydrolase, putative |
Leishmania mexicana | LmxM.36.5240 | glycosyl hydrolase, putative |
Mycobacterium leprae | ML0392c | Possible hydrolase |
Mus musculus | ENSMUSG00000062031 | ATH1, acid trehalase-like 1 (yeast) |
Mycobacterium tuberculosis | Rv3401 | Conserved protein |
Mycobacterium ulcerans | MUL_0906 | glycosyl hydrolase |
Saccharomyces cerevisiae | YPR026W | alpha,alpha-trehalase ATH1 |
Schmidtea mediterranea | mk4.006624.00 | |
Schmidtea mediterranea | mk4.000843.07 | Acid trehalase-like protein 1 |
Trypanosoma brucei gambiense | Tbg972.11.11970 | glycosyl hydrolase, putative |
Trypanosoma brucei | Tb927.11.10670 | glycosyl hydrolase, putative |
Trypanosoma congolense | TcIL3000.11.11340 | glycosyl hydrolase, putative |
Trypanosoma cruzi | TcCLB.506155.120 | glycosyl hydrolase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3462 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb11.01.2440 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2440 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2440 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.2440 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1316 | Escherichia coli | non-essential | goodall |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Saccharomyces cerevisiae | alpha,alpha-trehalase ATH1 | Compounds | References |
1 literature reference was collected for this gene.