pI: 7.9984 |
Length (AA): 544 |
MW (Da): 59580 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127428)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G02530 | TCP-1/cpn60 chaperonin family protein |
Arabidopsis thaliana | AT5G16070 | TCP-1/cpn60 chaperonin family protein |
Babesia bovis | BBOV_IV000230 | T-complex protein 1 zeta subunit |
Brugia malayi | Bm1_00545 | T-complex protein 1, zeta subunit |
Candida albicans | CaO19.3126 | similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Candida albicans | CaO19.10638 | similar to S. cerevisiae CCT6 (YDR188W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol |
Caenorhabditis elegans | CELE_F01F1.8 | Protein CCT-6, isoform B |
Cryptosporidium hominis | Chro.70466 | chaperonin |
Cryptosporidium parvum | cgd7_4220 | TCP-1 chaperonin |
Dictyostelium discoideum | DDB_G0277493 | chaperonin containing TCP1 zeta subunit |
Drosophila melanogaster | Dmel_CG8231 | T-cp1zeta |
Echinococcus granulosus | EgrG_000143600 | T complex protein 1 subunit zeta |
Entamoeba histolytica | EHI_178980 | hypothetical protein |
Entamoeba histolytica | EHI_125800 | chaperonin-containing TCP-1, zeta subunit, putative |
Echinococcus multilocularis | EmuJ_000143600 | T complex protein 1 subunit zeta |
Echinococcus multilocularis | EmuJ_000140900 | T complex protein 1 subunit zeta |
Giardia lamblia | GL50803_10231 | TCP-1 chaperonin subunit zeta |
Homo sapiens | ENSG00000146731 | chaperonin containing TCP1, subunit 6A (zeta 1) |
Homo sapiens | ENSG00000132141 | chaperonin containing TCP1, subunit 6B (zeta 2) |
Leishmania braziliensis | LbrM.13.1520 | chaperonin TCP20, putative |
Leishmania donovani | LdBPK_131400.1 | chaperonin TCP20, putative |
Leishmania infantum | LinJ.13.1400 | chaperonin TCP20, putative |
Leishmania major | LmjF.13.1660 | chaperonin TCP20, putative |
Leishmania mexicana | LmxM.13.1660 | chaperonin TCP20, putative |
Loa Loa (eye worm) | LOAG_01700 | T-complex protein 1 |
Mus musculus | ENSMUSG00000020698 | chaperonin containing Tcp1, subunit 6b (zeta) |
Mus musculus | 12466 | chaperonin containing Tcp1, subunit 6a (zeta) |
Neospora caninum | NCLIV_011140 | GL18351, related |
Oryza sativa | 4337802 | Os05g0147400 |
Plasmodium berghei | PBANKA_0107300 | T-complex protein 1 subunit zeta, putative |
Plasmodium falciparum | PF3D7_0608700 | T-complex protein 1 subunit zeta |
Plasmodium knowlesi | PKNH_1141500 | T-complex protein 1 subunit zeta, putative |
Plasmodium vivax | PVX_113595 | T-complex protein 1 subunit zeta, putative |
Plasmodium yoelii | PY02258 | putative chaperonin |
Saccharomyces cerevisiae | YDR188W | Cct6p |
Schistosoma japonicum | Sjp_0095780 | ko:K09498 T-complex protein 1 subunit zeta, putative |
Schistosoma mansoni | Smp_004990 | chaperonin containing t-complex protein 1 zeta subunit tcpz |
Schmidtea mediterranea | mk4.000511.03 | GH13725p |
Schmidtea mediterranea | mk4.002582.01 | T-complex protein 1 subunit zeta |
Trypanosoma brucei gambiense | Tbg972.11.3610 | T-complex protein 1, zeta subunit, putative |
Trypanosoma brucei | Tb927.11.3240 | T-complex protein 1, zeta subunit, putative |
Trypanosoma congolense | TcIL3000.11.3010 | T-complex protein 1, zeta subunit, putative |
Trypanosoma congolense | TcIL3000_0_41470 | T-complex protein 1, zeta subunit, putative |
Trypanosoma cruzi | TcCLB.509583.10 | chaperonin TCP20, putative |
Toxoplasma gondii | TGME49_318410 | TCP-1 chaperonin, putative |
Theileria parva | TP02_0937 | chaperonin 60 kDa, putative |
Trichomonas vaginalis | TVAG_303600 | chaperonin containing t-complex protein 1, zeta subunit, tcpz, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.0750 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.0750 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.0750 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.0750 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F01F1.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F01F1.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F01F1.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F01F1.8 | Caenorhabditis elegans | sterile | wormbase |
YDR188W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0107300 | Plasmodium berghei | Slow | plasmo |
TGME49_318410 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaaca fascicularis | T-complex protein 1 subunit beta | 535 aa | 26.3% | 548 aa | Compounds | References |
1 literature reference was collected for this gene.