pI: 7.4889 |
Length (AA): 419 |
MW (Da): 47943 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
57 | 175 | 4l5g (A) | 10 | 139 | 15.00 | 0.54 | 0.13 | 0.35091 | -0.05 |
114 | 418 | 2vg3 (A) | 45 | 294 | 34.00 | 0 | 1 | 0.901824 | 0.35 |
137 | 413 | 2vg0 (A) | 31 | 256 | 31.00 | 0 | 1 | 0.842998 | -0.03 |
139 | 402 | 3sh0 (A) | 19 | 228 | 36.00 | 0.000000000019 | 0.35 | 0.490072 | 1.64 |
198 | 419 | 3ugs (B) | 11 | 223 | 31.00 | 0 | 1 | 0.822833 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126777)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G60500 | dehydrodolichyl diphosphate synthase 7 |
Arabidopsis thaliana | AT5G58780 | Z,E-mixed heptaprenyl diphosphate synthase |
Arabidopsis thaliana | AT5G60510 | cis-prenyltransferase 9 |
Arabidopsis thaliana | AT2G17570 | cis-prenyltransferase 1 |
Arabidopsis thaliana | AT2G23410 | cis-prenyltransferase |
Arabidopsis thaliana | AT5G58770 | dehydrodolichyl diphosphate synthase 2 |
Arabidopsis thaliana | AT2G23400 | undecaprenyl pyrophosphate synthetase family protein |
Arabidopsis thaliana | AT5G58782 | dehydrodolichyl diphosphate synthase 4 |
Arabidopsis thaliana | AT5G58784 | dehydrodolichyl diphosphate synthase 5 |
Babesia bovis | BBOV_IV002310 | undecaprenyl pyrophosphate synthetase, putative |
Brugia malayi | Bm1_28770 | Undecaprenyl diphosphate synthase family protein |
Candida albicans | CaO19.4028 | Cis-prenyltransferase |
Candida albicans | CaO19.11511 | Cis-prenyltransferase |
Candida albicans | CaO19.12700 | cis-prenyltransferase-like orf |
Candida albicans | CaO19.5236 | cis-prenyltransferase-like orf |
Caenorhabditis elegans | CELE_T01G1.4 | Protein T01G1.4 |
Cryptosporidium parvum | cgd4_1510 | conserved hypothetical protein |
Chlamydia trachomatis | CT_450 | isoprenyl transferase |
Dictyostelium discoideum | DDB_G0291436 | hypothetical protein |
Drosophila melanogaster | Dmel_CG10778 | CG10778 gene product from transcript CG10778-RB |
Escherichia coli | b0174 | undecaprenyl pyrophosphate synthase |
Echinococcus granulosus | EgrG_000132300 | dehydrodolichyl diphosphate synthase |
Echinococcus multilocularis | EmuJ_000132300 | dehydrodolichyl diphosphate synthase |
Giardia lamblia | GL50803_15256 | Undecaprenyl pyrophosphate synthase |
Homo sapiens | ENSG00000117682 | dehydrodolichyl diphosphate synthase |
Leishmania braziliensis | LbrM.13.0020 | cis-prenyltransferase-like protein |
Leishmania donovani | LdBPK_130020.1 | cis-prenyltransferase-like protein |
Leishmania infantum | LinJ.13.0020 | cis-prenyltransferase-like protein |
Leishmania major | LmjF.13.0020 | cis-prenyltransferase-like protein |
Leishmania mexicana | LmxM.13.0020 | cis-prenyltransferase-like protein |
Loa Loa (eye worm) | LOAG_02395 | hypothetical protein |
Mycobacterium leprae | ML2467 | SHORT (C15) CHAIN Z-ISOPRENYL DIPHOSPHATE SYNTHASE (Z-FPP SYNTHASE) (Z-FARNESYL DIPHOSPHATE SYNTHASE) (Z-FPP SYNTHETASE) (Z-FARN |
Mycobacterium leprae | ML0634 | Probable Long (C50) chain Z-isoprenyl diphosphate synthase (Z-DECAPRENYL DIPHOSPHATE SYNTHASE) |
Mus musculus | ENSMUSG00000012117 | dehydrodolichyl diphosphate synthase |
Mycobacterium tuberculosis | Rv1086 | Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farn |
Mycobacterium tuberculosis | Rv2361c | Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase) |
Mycobacterium ulcerans | MUL_3614 | undecaprenyl pyrophosphate synthase |
Mycobacterium ulcerans | MUL_0193 | short (C15) chain Z-isoprenyl diphosphate synthase, UppS |
Mycobacterium ulcerans | MUL_3171 | Z-decaprenyl diphosphate synthase |
Neospora caninum | NCLIV_059180 | GF20994, related |
Oryza sativa | 4324755 | Os01g0857200 |
Oryza sativa | 4340251 | Os06g0167400 |
Oryza sativa | 4343863 | Os07g0607700 |
Onchocerca volvulus | OVOC2159 | Dehydrodolichyl diphosphate synthase homolog |
Plasmodium berghei | PBANKA_0704200 | dehydrodolichyl diphosphate synthetase, putative |
Plasmodium falciparum | PF3D7_0826400 | dehydrodolichyl diphosphate synthetase, putative |
Plasmodium knowlesi | PKNH_1320600 | dehydrodolichyl diphosphate synthetase, putative |
Plasmodium vivax | PVX_089040 | dehydrodolichyl diphosphate synthetase, putative |
Plasmodium yoelii | PY05575 | undecaprenyl pyrophosphate synthetase-like-related |
Plasmodium yoelii | PY05574 | hypothetical protein |
Saccharomyces cerevisiae | YBR002C | Rer2p |
Saccharomyces cerevisiae | YMR101C | Srt1p |
Schistosoma japonicum | Sjp_0052490 | ko:K00810 dehydrodolichyl diphosphate synthase [EC:2.5.1.-], putative |
Schistosoma mansoni | Smp_048520.2 | dehydrodolichyl diphosphate synthase (dedol-pp synthase) |
Schistosoma mansoni | Smp_048520.1 | dehydrodolichyl diphosphate synthase (dedol-pp synthase) |
Schistosoma mansoni | Smp_048520.3 | dehydrodolichyl diphosphate synthase (dedol-pp synthase) |
Schmidtea mediterranea | mk4.007105.00 | Dehydrodolichyl diphosphate synthase |
Schmidtea mediterranea | mk4.021140.01 | Dehydrodolichyl diphosphate synthase |
Trypanosoma brucei gambiense | Tbg972.7.6850 | cis-prenyltransferase-like protein, putative |
Trypanosoma brucei | Tb927.7.5880 | cis-prenyltransferase-like protein |
Trypanosoma congolense | TcIL3000_7_4880 | cis-prenyltransferase-like protein, putative |
Trypanosoma cruzi | TcCLB.508173.60 | cis-prenyltransferase, putative |
Toxoplasma gondii | TGME49_316770 | undecaprenyl diphosphate synthase |
Treponema pallidum | TP0603 | undecaprenyl pyrophosphate synthase |
Theileria parva | TP03_0421 | undecaprenyl diphosphate synthase, putative |
Trichomonas vaginalis | TVAG_313970 | undecaprenyl diphosphate synthase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0804 | undecaprenyl pyrophosphate synthase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.5880 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5880 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5880 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.5880 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0174 | Escherichia coli | essential | goodall |
YBR002C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_316770 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Undecaprenyl pyrophosphate synthase | Compounds | References |
1 literature reference was collected for this gene.