pI: 10.3429 |
Length (AA): 914 |
MW (Da): 108999 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 173 | 1b7f (A) | 123 | 286 | 17.00 | 0 | 1 | 0.38 | 0.23 |
7 | 81 | 1no8 (A) | 106 | 179 | 22.00 | 0.000000012 | 1 | 0.58 | -1.99 |
5 | 82 | 2ki2 (A) | 1 | 77 | 38.00 | 0.00022 | 1 | 0.593939 | -0.73 |
6 | 284 | 4wij (A) | 297 | 572 | 21.00 | 0.22 | 1 | 0.336452 | 0.47 |
8 | 78 | 2do4 (A) | 803 | 872 | 27.00 | 0.55 | 1 | 0.580281 | -1.77 |
4 | 83 | 1p27 (B) | 71 | 150 | 24.00 | 0.012 | 1 | 0.591632 | -2.02 |
6 | 88 | 2qfj (A) | 209 | 291 | 28.00 | 0.026 | 1 | 0.61091 | -1.78 |
7 | 82 | 2ki2 (A) | 3 | 77 | 39.00 | 0.00087 | 0.99 | 0.59326 | -0.69 |
8 | 115 | 3lqv (A) | 21 | 125 | 21.00 | 0.15 | 1 | 0.507233 | -1.37 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | gametocyte, Male Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | sporozoite, early ring, late ring, Female Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, early trophozoite, late trophozoite, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 0 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. | Otto TD |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127418)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G64200 | SC35-like splicing factor |
Arabidopsis thaliana | AT3G13570 | SC35-like splicing factor 30A |
Arabidopsis thaliana | AT1G55310 | SC35-like splicing factor 33 |
Arabidopsis thaliana | AT3G55460 | SC35-like splicing factor 30 |
Babesia bovis | BBOV_II001870 | RNA recognition motif containing protein |
Babesia bovis | BBOV_IV008500 | Ser/Arg-rich splicing factor, putative |
Brugia malayi | Bm1_29600 | RNA recognition motif domain containing protein |
Caenorhabditis elegans | CELE_EEED8.7 | Protein RSP-4, isoform B |
Cryptosporidium hominis | Chro.70117 | dentin phosphoryn |
Cryptosporidium hominis | Chro.60316 | splicing factor |
Cryptosporidium parvum | cgd7_940 | splicing factor RRM domain containing protein; T22E16.120 SC35-like splicing factor |
Cryptosporidium parvum | cgd6_2740 | RRM domain containing protein; T22E16.120 Sc35-like splicing factor |
Drosophila melanogaster | Dmel_CG5442 | CG5442 gene product from transcript CG5442-RC |
Echinococcus granulosus | EgrG_000710900 | FUS interacting serine arginine rich protein 1 |
Echinococcus granulosus | EgrG_000802000 | Splicing factor arginine:serine rich 2 |
Entamoeba histolytica | EHI_048210 | splicing factor, arginine/serine-rich, putative |
Echinococcus multilocularis | EmuJ_000710900 | FUS interacting serine arginine rich protein 1 |
Echinococcus multilocularis | EmuJ_000461600 | FUS interacting serine arginine rich protein 1 |
Echinococcus multilocularis | EmuJ_000802000 | Splicing factor, arginine:serine rich 2 |
Homo sapiens | ENSG00000263465 | serine/arginine-rich splicing factor 8 |
Homo sapiens | ENSG00000161547 | serine/arginine-rich splicing factor 2 |
Homo sapiens | ENSG00000188529 | serine/arginine-rich splicing factor 10 |
Loa Loa (eye worm) | LOAG_00933 | hypothetical protein |
Mus musculus | ENSMUSG00000034120 | serine/arginine-rich splicing factor 2 |
Mus musculus | ENSMUSG00000028676 | serine/arginine-rich splicing factor 10 |
Neospora caninum | NCLIV_036130 | CBR-RSP-4 protein, related |
Oryza sativa | 4345884 | Os08g0486200 |
Oryza sativa | 4344009 | Os07g0633200 |
Oryza sativa | 4352590 | Os12g0572400 |
Oryza sativa | 4343955 | Os07g0623300 |
Oryza sativa | 4328900 | Os02g0252100 |
Plasmodium berghei | PBANKA_0921600 | RNA-binding protein, putative |
Plasmodium berghei | PBANKA_1103000 | serine/arginine-rich splicing factor 12, putative |
Plasmodium falciparum | PF3D7_1126800 | RNA-binding protein, putative |
Plasmodium falciparum | PF3D7_0503300 | serine/arginine-rich splicing factor 12 |
Plasmodium knowlesi | PKNH_0924800 | RNA-binding protein, putative |
Plasmodium knowlesi | PKNH_1030300 | serine/arginine-rich splicing factor 12, putative |
Plasmodium vivax | PVX_097740 | serine/arginine-rich splicing factor 12, putative |
Plasmodium vivax | PVX_091955 | RNA-binding protein, putative |
Plasmodium yoelii | PY06769 | hypothetical protein |
Plasmodium yoelii | PY04699 | PR264 |
Plasmodium yoelii | PY02124 | dentin phosphoryn |
Schistosoma japonicum | Sjp_0003120 | similar to 35 kDa SR repressor protein, putative |
Schistosoma japonicum | Sjp_0200880 | Splicing factor, arginine/serine-rich 2, putative |
Schistosoma mansoni | Smp_032320.2 | serine/arginine rich splicing factor |
Schistosoma mansoni | Smp_113620.3 | serine/arginine rich splicing factor |
Schistosoma mansoni | Smp_113620.1 | serine/arginine rich splicing factor |
Schistosoma mansoni | Smp_032320.6 | serine/arginine rich splicing factor |
Schistosoma mansoni | Smp_113620.4 | serine/arginine rich splicing factor |
Schistosoma mansoni | Smp_032320.1 | serine/arginine rich splicing factor |
Schmidtea mediterranea | mk4.001733.03 | |
Toxoplasma gondii | TGME49_272440 | RNA recognition motif-containing protein |
Toxoplasma gondii | TGME49_270640 | RNA recognition motif-containing protein |
Theileria parva | TP04_0393 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_EEED8.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_EEED8.7 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0921600 | Plasmodium berghei | Dispensable | plasmo |
PBANKA_1103000 | Plasmodium berghei | Essential | plasmo |
TGME49_272440 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_270640 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.