pI: 7.3706 |
Length (AA): 731 |
MW (Da): 81263 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128241)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G02060 | protein PROLIFERA |
Babesia bovis | BBOV_IV007280 | ATP dependent DNA helicase, putative |
Brugia malayi | Bm1_04660 | replication licensing factor MCM7 |
Brugia malayi | Bm1_31460 | replication licensing factor MCM7 |
Candida albicans | CaO19.7832 | chromatin binding/ DNA replication |
Candida albicans | CaO19.202 | chromatin binding/ DNA replication |
Candida albicans | CaO19.7831 | one of three C. albicans genes with potential N terminal DUF202 similar to yidH (E. coli ) |
Candida albicans | CaO19.201 | one of three C. albicans genes with potential N terminal DUF202 similar to yidH (E. coli ) |
Caenorhabditis elegans | CELE_F32D1.10 | Protein MCM-7 |
Cryptosporidium hominis | Chro.40117 | minichromosome maintenance protein mcm7p |
Cryptosporidium parvum | cgd4_970 | DNA replication licensing factor MCM7 like AAA+ ATpase |
Dictyostelium discoideum | DDB_G0282933 | MCM family protein |
Drosophila melanogaster | Dmel_CG4978 | Minichromosome maintenance 7 |
Echinococcus granulosus | EgrG_000510700 | DNA replication licensing factor mcm7 |
Entamoeba histolytica | EHI_158110 | DNA replication licensing factor, putative |
Echinococcus multilocularis | EmuJ_000510700 | DNA replication licensing factor mcm7 |
Giardia lamblia | GL50803_10765 | MCM7 |
Homo sapiens | ENSG00000166508 | minichromosome maintenance complex component 7 |
Leishmania braziliensis | LbrM.32.3220 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania donovani | LdBPK_323120.1 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania infantum | LinJ.32.3120 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania major | LmjF.32.2960 | minichromosome maintenance (MCM) complex subunit, putative |
Leishmania mexicana | LmxM.31.2960 | minichromosome maintenance (MCM) complex subunit, putative |
Loa Loa (eye worm) | LOAG_04710 | replication licensing factor MCM7 |
Mus musculus | ENSMUSG00000029730 | minichromosome maintenance deficient 7 (S. cerevisiae) |
Neospora caninum | NCLIV_051090 | DNA replication licensing factor, putative |
Oryza sativa | 4352514 | Os12g0560700 |
Plasmodium berghei | PBANKA_0803100 | DNA replication licensing factor MCM7, putative |
Plasmodium falciparum | PF3D7_0705400 | DNA replication licensing factor MCM7 |
Plasmodium knowlesi | PKNH_0103900 | DNA replication licensing factor MCM7, putative |
Plasmodium vivax | PVX_087810 | DNA replication licensing factor MCM7, putative |
Plasmodium yoelii | PY03236 | DNA replication licensing factor mcm7 |
Saccharomyces cerevisiae | YBR202W | mini-chromosome maintenance complex protein 7 |
Schistosoma japonicum | Sjp_0112300 | ko:K02210 minichromosome maintenance protein 7 (cell division control protein, putative |
Schistosoma japonicum | Sjp_0096330 | DNA replication licensing factor mcm7-B, putative |
Schistosoma japonicum | Sjp_0051550 | DNA replication licensing factor mcm7-A, putative |
Schistosoma mansoni | Smp_032500 | DNA replication licensing factor MCM7 |
Schmidtea mediterranea | mk4.033904.00 | DNA replication licensing factor MCM7 |
Schmidtea mediterranea | mk4.029139.00 | DNA replication licensing factor MCM7 |
Schmidtea mediterranea | mk4.079970.00 | DNA replication licensing factor MCM7 |
Trypanosoma brucei gambiense | Tbg972.11.18100 | minichromosome maintenance (MCM) complex subunit, putative |
Trypanosoma brucei | Tb927.11.16140 | DNA replication licensing factor MCM7 |
Trypanosoma cruzi | TcCLB.508707.210 | DNA replication licensing factor MCM7, putative |
Toxoplasma gondii | TGME49_237220 | DNA replication licensing factor Mcm7, putative |
Theileria parva | TP03_0236 | DNA replication licensing factor MCM7, putative |
Trichomonas vaginalis | TVAG_130190 | DNA replication licensing factor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.7810 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.7810 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.7810 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.7810 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F32D1.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F32D1.10 | Caenorhabditis elegans | sterile | wormbase |
YBR202W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0803100 | Plasmodium berghei | Essential | plasmo |
TGME49_237220 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.