Detailed view for PF3D7_1132200

Basic information

TDR Targets ID: 1800
Plasmodium falciparum, T-complex protein 1 subunit alpha
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.0198 | Length (AA): 544 | MW (Da): 60261 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00118   TCP-1/cpn60 chaperonin family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005832   chaperonin-containing T-complex  
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0044267   cellular protein metabolic process  
GO:0007010   cytoskeleton organization and biogenesis  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 532 1a6d (B) 20 521 41.00 0 1 1.58 -1.55
14 544 1iok (A) 11 526 26.00 0.00000000023 1 1.12 0.18
3 533 4b2t (A) 5 533 61.00 0 1 1.5797 -0.15
3 533 4b2t (a) 1005 1533 63.00 0 1 1.0017 2.03
209 366 1ass (A) 1 152 37.00 0 1 0.862041 -1.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127998)

Species Accession Gene Product
Arabidopsis thaliana AT3G20050   T-complex protein 1 subunit alpha
Babesia bovis BBOV_I003340   t-complex protein 1, alpha subunit, putative
Brugia malayi Bm1_43680   T-complex protein 1, alpha subunit
Candida albicans CaO19.401   similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Candida albicans CaO19.8031   similar to S. cerevisiae TCP1 (YDR212W) subunit of chaperonin Cct ring complex involved in cytoskeleton assembly and protein fol
Caenorhabditis elegans CELE_T05C12.7   Protein CCT-1
Cryptosporidium hominis Chro.20068   t-complex protein 1, alpha subunit
Cryptosporidium parvum cgd2_600   t-complex protein 1, alpha subunit
Chlamydia trachomatis CT_604   chaperonin GroEL
Dictyostelium discoideum DDB_G0269190   chaperonin containing TCP1 alpha subunit
Drosophila melanogaster Dmel_CG5374   Tcp1-like
Echinococcus granulosus EgrG_000826700   T complex protein 1 subunit alpha
Entamoeba histolytica EHI_155220   T-complex protein 1, alpha subunit, putative
Echinococcus multilocularis EmuJ_000826700   T complex protein 1 subunit alpha
Giardia lamblia GL50803_91919   TCP-1 chaperonin subunit alpha
Homo sapiens ENSG00000120438   t-complex 1
Leishmania braziliensis LbrM.32.3560   chaperonin alpha subunit, putative
Leishmania donovani LdBPK_323470.1   chaperonin alpha subunit, putative
Leishmania infantum LinJ.32.3470   chaperonin alpha subunit, putative
Leishmania major LmjF.32.3270   chaperonin alpha subunit, putative
Leishmania mexicana LmxM.31.3270   chaperonin alpha subunit, putative
Loa Loa (eye worm) LOAG_03598   hypothetical protein
Loa Loa (eye worm) LOAG_03164   T-complex protein 1
Mus musculus ENSMUSG00000068039   t-complex protein 1
Neospora caninum NCLIV_030660   TCP-1/cpn60 family chaperonin, putative
Oryza sativa 4336600   Os04g0551800
Plasmodium berghei PBANKA_0916200   T-complex protein 1 subunit alpha, putative
Plasmodium falciparum PF3D7_1132200   T-complex protein 1 subunit alpha
Plasmodium knowlesi PKNH_0930400   T-complex protein 1 subunit alpha, putative
Plasmodium vivax PVX_092215   T-complex protein 1 subunit alpha, putative
Plasmodium yoelii PY03629   t-complex protein 1, alpha subunit
Saccharomyces cerevisiae YDR212W   chaperonin-containing T-complex alpha subunit TCP1
Schistosoma japonicum Sjp_0082530   ko:K09493 T-complex protein 1 subunit alpha, putative
Schistosoma mansoni Smp_017360   T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)
Schmidtea mediterranea mk4.003845.01   T-complex protein 1 subunit alpha
Schmidtea mediterranea mk4.002735.04   T-complex protein 1 subunit alpha
Schmidtea mediterranea mk4.017724.00   T-complex protein 1 subunit alpha
Schmidtea mediterranea mk4.004933.01   T-complex protein 1 subunit alpha
Schmidtea mediterranea mk4.004933.00   T-complex protein 1 subunit alpha
Trypanosoma brucei gambiense Tbg972.11.18900   T-complex protein 1, alpha subunit, putative
Trypanosoma brucei Tb427tmp.01.8510   T-complex protein 1, alpha subunit, putative
Trypanosoma brucei Tb927.11.16760   T-complex protein 1, alpha subunit, putative
Trypanosoma congolense TcIL3000.11.16670   T-complex protein 1, alpha subunit, putative
Trypanosoma cruzi TcCLB.511531.40   chaperonin alpha subunit, putative
Trypanosoma cruzi TcCLB.511025.70   chaperonin alpha subunit, putative
Toxoplasma gondii TGME49_229990   T-complex protein 1 subunit alpha, putative
Theileria parva TP03_0183   T-complex protein 1, alpha subunit , putative
Trichomonas vaginalis TVAG_364270   chaperonin containing t-complex protein 1, beta subunit, tcpb, putative
Trichomonas vaginalis TVAG_350510   chaperonin containing t-complex protein 1, eta subunit, tcph, putative

Essentiality

PF3D7_1132200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.8510 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.8510 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.8510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.8510 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05C12.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05C12.7 Caenorhabditis elegans larval arrest wormbase
CELE_T05C12.7 Caenorhabditis elegans slow growth wormbase
CELE_T05C12.7 Caenorhabditis elegans sterile wormbase
YDR212W Saccharomyces cerevisiae inviable yeastgenome
TGME49_229990 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaaca fascicularis T-complex protein 1 subunit beta 535 aa 34.4% 546 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1132200 (Plasmodium falciparum), T-complex protein 1 subunit alpha
Title for this comment
Comment