Detailed view for Tb927.9.11850

Basic information

TDR Targets ID: 18021
Trypanosoma brucei, structural maintenance of chromosome 1, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.8457 | Length (AA): 1275 | MW (Da): 144540 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02463   RecF/RecN/SMC N terminal domain
PF06470   SMC proteins Flexible Hinge Domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0000796   condensin complex  
GO:0000070   mitotic sister chromatid segregation  
GO:0046982   protein heterodimerization activity  
GO:0008278   cohesin complex  
GO:0007064   mitotic sister chromatid cohesion  
GO:0005694   chromosome  
GO:0005634   nucleus  
GO:0003682   chromatin binding  
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0051276   chromosome organization and biogenesis  
GO:0007059   chromosome segregation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127449)

Species Accession Gene Product
Arabidopsis thaliana AT3G54670   structural maintenance of chromosomes 1
Babesia bovis BBOV_IV004610   structural maintenance of chromosome 1-like protein, putative
Brugia malayi Bm1_12960   SMC family, C-terminal domain containing protein
Candida albicans CaO19.11845   potential SMC chromosomal ATPase similar to S. cerevisiae SMC1 (YFL008W) nuclear cohesin complex ATPase
Candida albicans CaO19.4367   potential SMC chromosomal ATPase similar to S. cerevisiae SMC1 (YFL008W) nuclear cohesin complex ATPase
Caenorhabditis elegans CELE_F28B3.7   Protein HIM-1, isoform B
Cryptosporidium hominis Chro.20291   Xenopus 14s cohesin smc1 subunit
Cryptosporidium parvum cgd2_2750   SMC1 structural maintenance of chromosomes 1
Dictyostelium discoideum DDB_G0291752   structural maintenance of chromosome protein
Drosophila melanogaster Dmel_CG6057   CG6057 gene product from transcript CG6057-RA
Echinococcus granulosus EgrG_000802900   expressed protein
Echinococcus granulosus EgrG_000803000   structural maintenance of chromosomes protein
Entamoeba histolytica EHI_050790   structural maintenance of chromosomes protein
Echinococcus multilocularis EmuJ_000803000   structural maintenance of chromosomes protein
Echinococcus multilocularis EmuJ_000802900   expressed protein
Giardia lamblia GL50803_16188   SMC1 beta-like protein
Homo sapiens ENSG00000077935   structural maintenance of chromosomes 1B
Homo sapiens ENSG00000072501   structural maintenance of chromosomes 1A
Leishmania braziliensis LbrM.34.3440   structural maintenance of chromosome (SMC) family protein, putative
Leishmania donovani LdBPK_353560.1   structural maintenance of chromosome (SMC) family protein, putative
Leishmania infantum LinJ.35.3560   structural maintenance of chromosome (SMC) family protein, putative
Leishmania major LmjF.35.3510   structural maintenance of chromosome (SMC) family protein, putative
Leishmania mexicana LmxM.34.3510   structural maintenance of chromosome (SMC) family protein, putative
Loa Loa (eye worm) LOAG_05552   hypothetical protein
Mus musculus ENSMUSG00000022432   structural maintenance of chromosomes 1B
Mus musculus ENSMUSG00000041133   structural maintenance of chromosomes 1A
Neospora caninum NCLIV_041160   Xenopus 14s cohesin smc1 subunit, related
Oryza sativa 4352932   Os12g0641500
Plasmodium berghei PBANKA_0917500   structural maintenance of chromosomes protein 1, putative
Plasmodium falciparum PF3D7_1130700   structural maintenance of chromosomes protein 1, putative
Plasmodium knowlesi PKNH_0928800   structural maintenance of chromosomes protein 1, putative
Plasmodium vivax PVX_092140   structural maintenance of chromosome protein, putative
Plasmodium yoelii PY00653   chromosome segregation protein smc1
Saccharomyces cerevisiae YFL008W   cohesin subunit SMC1
Schistosoma japonicum Sjp_0015150   ko:K06636 structural maintenance of chromosome 1, putative
Schistosoma mansoni Smp_136970   chondroitin sulfate proteoglycan
Schmidtea mediterranea mk4.004021.04   Structural maintenance of chromosomes protein 1B
Schmidtea mediterranea mk4.009253.01  
Schmidtea mediterranea mk4.004021.02   Structural maintenance of chromosomes protein 1B
Schmidtea mediterranea mk4.004021.01  
Trypanosoma brucei gambiense Tbg972.9.7140   structural maintenance of chromosome 1, putative
Trypanosoma brucei Tb927.9.11850   structural maintenance of chromosome 1, putative
Trypanosoma congolense TcIL3000_9_4840   structural maintenance of chromosome 1, putative
Trypanosoma cruzi TcCLB.507011.60   structural maintenance of chromosome (SMC) family protein, putative
Trypanosoma cruzi TcCLB.507005.60   structural maintenance of chromosome (SMC) family protein, putative
Toxoplasma gondii TGME49_288700   RecF/RecN/SMC N terminal domain-containing protein
Theileria parva TP01_0286   SMC protein, putative
Trichomonas vaginalis TVAG_162180   cohesin subunit Smc1
Trichomonas vaginalis TVAG_266830   cohesin subunit Smc1

Essentiality

Tb927.9.11850 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2970 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.2970 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2970 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.2970 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F28B3.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_F28B3.7 Caenorhabditis elegans larval arrest wormbase
CELE_F28B3.7 Caenorhabditis elegans larval lethal wormbase
CELE_F28B3.7 Caenorhabditis elegans sterile wormbase
YFL008W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0917500 Plasmodium berghei Essential plasmo
TGME49_288700 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.9.11850 (Trypanosoma brucei), structural maintenance of chromosome 1, putative
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