Detailed view for PF3D7_1132700

Basic information

TDR Targets ID: 1806
Plasmodium falciparum, 50S ribosomal protein L2, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.2233 | Length (AA): 333 | MW (Da): 37805 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00181   Ribosomal Proteins L2, RNA binding domain
PF03947   Ribosomal Proteins L2, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0000315   organellar large ribosomal subunit  
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005739   mitochondrion  
GO:0005622   intracellular  
GO:0016740   transferase activity  
GO:0003735   structural constituent of ribosome  
GO:0003723   RNA binding  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
43 319 1nkw (A) 4 273 43.00 0 1 1.05 2.63
72 319 2aw4 (C) 23 269 53.00 0 1 1.18 1.85
109 244 1rl2 (A) 60 195 51.00 0 1 1.04 -1.22
43 321 5dm6 (A) 4 275 43.00 0 1 1.19164 1.15
109 244 1rl2 (A) 60 195 51.00 0 1 1.07521 -0.65

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs, sporozoite, early ring, early trophozoite, late ring, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, early schizont, late schizont, late trophozoite, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, Male Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_126641)

Species Accession Gene Product
Arabidopsis thaliana AT4G36130   60S ribosomal protein L8-3
Arabidopsis thaliana AT2G44065   ribosomal protein L2 family protein
Arabidopsis thaliana ArthCp085   50S ribosomal protein L2
Arabidopsis thaliana AT3G51190   60S ribosomal protein L8-2
Arabidopsis thaliana AT2G18020   60S ribosomal protein L8-1
Arabidopsis thaliana ArthCp064   50S ribosomal protein L2
Babesia bovis BBOV_III011800   ribosomal protein L2 family protein
Babesia bovis BBOV_IV007450   ribosomal protein L2, putative
Brugia malayi Bm1_09075   60S ribosomal protein L8
Brugia malayi Bm1_11070   Ribosomal Proteins L2, RNA binding domain containing protein
Candida albicans CaO19.5420   likely mitochondrial ribosomal protein similar to S. cerevisiae RML2 (YEL050C) large subunit protein L2
Candida albicans CaO19.12875   likely mitochondrial ribosomal protein similar to S. cerevisiae RML2 (YEL050C) large subunit protein L2
Caenorhabditis elegans CELE_B0250.1   Protein RPL-2
Caenorhabditis elegans CELE_F56B3.8   Protein MRPL-2
Cryptosporidium hominis Chro.70243   60S ribosomal protein L8
Cryptosporidium parvum cgd7_2110   60S ribosomal proteins L8/L2
Chlamydia trachomatis CT_525   50S ribosomal protein L2
Dictyostelium discoideum DidioMp24   ribosomal protein L2
Dictyostelium discoideum DDB_G0274113   60S ribosomal protein L8
Drosophila melanogaster Dmel_CG1263   Ribosomal protein L8
Drosophila melanogaster Dmel_CG7636   mitochondrial ribosomal protein L2
Escherichia coli b3317   50S ribosomal subunit protein L2
Echinococcus granulosus EgrG_000970050   5'partial|39S ribosomal protein L2 mitochondrial|39S ribosomal protein L2, mitochondrial
Echinococcus granulosus EgrG_000078000   60S ribosomal protein L8
Entamoeba histolytica EHI_127200   60S ribosomal protein L2/L8, putative
Entamoeba histolytica EHI_150470   60S ribosomal protein L2/L8, putative
Entamoeba histolytica EHI_181180   60S ribosomal protein L2/L8, putative
Echinococcus multilocularis EmuJ_000078000   60S ribosomal protein L8
Echinococcus multilocularis EmuJ_000970050   39S ribosomal protein L2, mitochondrial
Giardia lamblia GL50803_16086   Ribosomal protein L2
Homo sapiens ENSG00000112651   mitochondrial ribosomal protein L2
Homo sapiens ENSG00000161016   ribosomal protein L8
Leishmania braziliensis LbrM.34.1350   60S ribosomal protein L2, putative
Leishmania braziliensis LbrM.34.1360   60S ribosomal protein L2, putative
Leishmania braziliensis LbrM.32.4140   60S ribosomal protein L2, putative
Leishmania infantum LinJ.35.1440   60S ribosomal protein L2, putative
Leishmania infantum LinJ.35.1450   60S ribosomal protein L2, putative
Leishmania infantum LinJ.32.4050   60S ribosomal protein L2, putative
Leishmania major LmjF.35.1430   60S ribosomal protein L2, putative
Leishmania major LmjF.35.1440   60S ribosomal protein L2, putative
Leishmania major LmjF.32.3900   60S ribosomal protein L2, putative
Leishmania mexicana LmxM.34.1430   60S ribosomal protein L2, putative
Leishmania mexicana LmxM.34.1440   60S ribosomal protein L2, putative
Leishmania mexicana LmxM.31.3900   60S ribosomal protein L2, putative
Loa Loa (eye worm) LOAG_02792   60S ribosomal protein L8
Loa Loa (eye worm) LOAG_08167   ribosomal Proteins L2
Mycobacterium leprae ML1860c   PROBABLE 50S ribosomal protein L2 RPLB
Mus musculus ENSMUSG00000003970   ribosomal protein L8
Mus musculus ENSMUSG00000002767   mitochondrial ribosomal protein L2
Mycobacterium tuberculosis Rv0704   50S ribosomal protein L2 RplB
Mycobacterium ulcerans MUL_0793   50S ribosomal protein L2
Neospora caninum NCLIV_008690   Ribosomal protein L2, related
Neospora caninum NCLIV_021080   hypothetical protein
Oryza sativa 6450181   ribosomal protein L2
Oryza sativa 3131421   50S ribosomal protein L2
Oryza sativa 3131424   50S ribosomal protein L2
Oryza sativa 9269991   Os10g0573450
Oryza sativa 4352560   Os12g0567700
Plasmodium berghei PBANKA_0915700   50S ribosomal protein L2, putative
Plasmodium berghei PBANKA_1231700   60S ribosomal protein L2, putative
Plasmodium falciparum PF3D7_1132700   50S ribosomal protein L2, putative
Plasmodium falciparum PF3D7_0516900   60S ribosomal protein L2
Plasmodium knowlesi PKNH_1016400   60S ribosomal protein L2, putative
Plasmodium knowlesi PKNH_0930900   50S ribosomal protein L2, putative
Plasmodium vivax PVX_080405   60S ribosomal protein L2, putative
Plasmodium vivax PVX_092240   50S ribosomal protein L2, putative
Plasmodium yoelii PY05952   ribosomal protein L2
Plasmodium yoelii PY04343   60S ribosomal protein L8
Saccharomyces cerevisiae YEL050C   mitochondrial 54S ribosomal protein RML2
Saccharomyces cerevisiae YFR031C-A   ribosomal 60S subunit protein L2A
Saccharomyces cerevisiae YIL018W   ribosomal 60S subunit protein L2B
Schistosoma japonicum Sjp_0117250   IPR002171,Ribosomal protein L2,domain-containing
Schistosoma japonicum Sjp_0093740   IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0131760   IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0133610   IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0201040   ko:K02938 large subunit ribosomal protein L8e, putative
Schistosoma japonicum Sjp_0055100   IPR002171,Ribosomal protein L2;IPR010916,TonB box, N-terminal;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0315770   60S ribosomal protein L8, putative
Schistosoma japonicum Sjp_0118590   IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0010210   ko:K02886 large subunit ribosomal protein L2, putative
Schistosoma japonicum Sjp_0033190   IPR002171,Ribosomal protein L2;IPR008991,Translation protein SH3-like,domain-containing
Schistosoma japonicum Sjp_0132460   IPR002171,Ribosomal protein L2,domain-containing
Schistosoma mansoni Smp_151770   mitochondrial ribosomal protein L2
Schistosoma mansoni Smp_051260   60S ribosomal protein L8
Schmidtea mediterranea mk4.001703.06   39S ribosomal protein L2, mitochondrial
Schmidtea mediterranea mk4.000652.07   60S ribosomal protein L8
Schmidtea mediterranea mk4.050118.01  
Trypanosoma brucei gambiense Tbg972.11.18280   60S ribosomal protein L2, putative,60S ribosomal protein L8, putative
Trypanosoma brucei gambiense Tbg972.5.1540   60S ribosomal protein L2, putative,60S ribosomal protein L8, putative
Trypanosoma brucei Tb927.5.1110   60S ribosomal protein L8, putative
Trypanosoma brucei Tb427tmp.01.7960   60S ribosomal protein L2, putative
Trypanosoma brucei Tb927.11.16280   60S ribosomal protein L8, putative
Trypanosoma congolense TcIL3000.11.16190   60S ribosomal protein L8, putative
Trypanosoma congolense TcIL3000_5_960   60S ribosomal protein L8, putative
Trypanosoma cruzi TcCLB.511527.34   60S ribosomal protein L2, putative
Trypanosoma cruzi TcCLB.508299.60   60S ribosomal protein L8, putative
Trypanosoma cruzi TcCLB.511181.100   60S ribosomal protein L2, putative
Toxoplasma gondii TGME49_254400   LSU ribosomal protein L2P, putative
Toxoplasma gondii TGME49_204020   ribosomal protein RPL8
Treponema pallidum TP0192   50S ribosomal protein L2
Theileria parva TP01_1051   60S ribosomal protein L8, putative
Theileria parva TP03_0269   60S ribosomal protein L2, putative
Trichomonas vaginalis TVAG_371270   60S ribosomal protein L8, putative
Trichomonas vaginalis TVAG_104490   60S ribosomal protein L8, putative
Trichomonas vaginalis TVAG_005910   50S ribosomal protein L2, putative
Trichomonas vaginalis TVAG_484180   50S ribosomal protein L2, putative
Trichomonas vaginalis TVAG_487750   ribosomal protein L2, putative
Wolbachia endosymbiont of Brugia malayi Wbm0338   50S ribosomal protein L2

Essentiality

PF3D7_1132700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu716 Mycobacterium tuberculosis essential nmpdr
Tb11.01.7960 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.7960 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7960 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.7960 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.5.1110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.5.1110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.1110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.5.1110 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3317 Escherichia coli essential goodall
CELE_B0250.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0250.1 Caenorhabditis elegans larval arrest wormbase
CELE_B0250.1 Caenorhabditis elegans slow growth wormbase
CELE_B0250.1 Caenorhabditis elegans sterile wormbase
CELE_F56B3.8 Caenorhabditis elegans larval arrest wormbase
CELE_F56B3.8 Caenorhabditis elegans slow growth wormbase
TGME49_204020 Toxoplasma gondii Probably essential sidik
TGME49_254400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1132700 (Plasmodium falciparum), 50S ribosomal protein L2, putative
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