Detailed view for Tb927.7.3070

Basic information

TDR Targets ID: 18062
Trypanosoma brucei, UAA transporter family, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.4772 | Length (AA): 498 | MW (Da): 54850 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08449   UAA transporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0055085   transmembrane transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127044)

Species Accession Gene Product
Arabidopsis thaliana AT2G02810   UDP-galactose transporter 1
Arabidopsis thaliana AT5G59740   UDP-galactose/UDP-glucose transporter 5B
Arabidopsis thaliana AT1G14360   UDP-galactose transporter 3
Arabidopsis thaliana AT3G46180   UDP-galactose transporter 5
Babesia bovis BBOV_IV011720   UDP-galactose transporter, putative
Brugia malayi Bm1_50545   Paps
Candida albicans CaO19.14095   UDP-galactose transporter
Candida albicans CaO19.6803   UDP-galactose transporter
Caenorhabditis elegans CELE_M03F8.2   Protein PST-1, isoform A
Caenorhabditis elegans CELE_Y111B2A.20   Protein HUT-1
Cryptosporidium hominis Chro.10013   solute carrier family 35, member 2
Cryptosporidium parvum cgd1_40   UDP-galactose transporter, predicted signal peptide and 9 transmembrane domains
Dictyostelium discoideum DDB_G0269602   hypothetical protein
Dictyostelium discoideum DDB_G0288929   hypothetical protein
Drosophila melanogaster Dmel_CG7623   slalom
Drosophila melanogaster Dmel_CG5802   medial glomeruli
Echinococcus granulosus EgrG_000822000   solute carrier family 35 member b1
Echinococcus granulosus EgrG_000229400   adenosine 3' phospho 5' phosphosulfate
Entamoeba histolytica EHI_068590   UDP-galactose transporter-related protein 1, putative
Entamoeba histolytica EHI_041050   UDP-galactose transporter-related protein 1, putative
Echinococcus multilocularis EmuJ_000822000   solute carrier family 35 member b1
Echinococcus multilocularis EmuJ_000229400   adenosine 3' phospho 5' phosphosulfate
Giardia lamblia GL50803_15483   Hypothetical protein
Homo sapiens ENSG00000121073   solute carrier family 35, member B1
Homo sapiens ENSG00000157593   solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2
Leishmania braziliensis LbrM.22.0910   hypothetical protein, conserved
Leishmania donovani LdBPK_220830.1   UDP-galactose transporter, putative
Leishmania infantum LinJ.22.0830   hypothetical protein, conserved
Leishmania major LmjF.22.1010   UDP-galactose transporter, putative
Leishmania mexicana LmxM.22.1010   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03188   adenosine 3'-phospho 5'-phosphosulfate transporter 1 PAPS
Mus musculus 110172   solute carrier family 35, member B1
Mus musculus ENSMUSG00000037089   solute carrier family 35, member B2
Neospora caninum NCLIV_008860   hypothetical protein
Oryza sativa 4341421   Os06g0593100
Oryza sativa 4337618   Os05g0115700
Plasmodium berghei PBANKA_0934300   UDP-galactose transporter, putative
Plasmodium falciparum PF3D7_1113300   UDP-galactose transporter, putative
Plasmodium knowlesi PKNH_0910900   UDP-galactose transporter, putative
Plasmodium vivax PVX_091310   UDP-galactose transporter, putative
Plasmodium yoelii PY04044   solute carrier family 35, member 2, putative
Saccharomyces cerevisiae YPL244C   Hut1p
Schistosoma japonicum Sjp_0044040   Adenosine 3'-phospho 5'-phosphosulfate transporter 1, putative
Schistosoma japonicum Sjp_0044020   Adenosine 3'-phospho 5'-phosphosulfate transporter 1, putative
Schistosoma japonicum Sjp_0044050   Golgin subfamily A member 3, putative
Schistosoma japonicum Sjp_0085770   Solute carrier family 35 member B1, putative
Schistosoma mansoni Smp_172390   UDP-galactose transporter
Schistosoma mansoni Smp_171120   UDP-galactose transporter
Schmidtea mediterranea mk4.000871.03   Solute carrier family 35 B1
Trypanosoma brucei gambiense Tbg972.7.3370   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.3070   UAA transporter family, putative
Trypanosoma congolense TcIL3000_0_29650   UAA transporter family, putative
Trypanosoma congolense TcIL3000_7_2200   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510531.10   UAA transporter family, putative
Trypanosoma cruzi TcCLB.511817.280   UAA transporter family, putative
Toxoplasma gondii TGME49_254580   UDP-galactose transporter family protein
Theileria parva TP01_1136   hypothetical protein
Trichomonas vaginalis TVAG_100060   UDP-galactose transporter, putative

Essentiality

Tb927.7.3070 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3070 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.3070 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.3070 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.3070 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y111B2A.20 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y111B2A.20 Caenorhabditis elegans slow growth wormbase
CELE_Y111B2A.20 Caenorhabditis elegans sterile wormbase
PBANKA_0934300 Plasmodium berghei Essential plasmo
TGME49_254580 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Tb927.7.3070 (Trypanosoma brucei), UAA transporter family, putative
Title for this comment
Comment