pI: 6.7061 |
Length (AA): 325 |
MW (Da): 36492 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 189 | 1a9n (A) | 2 | 163 | 40.00 | 0 | 1 | 0.962955 | -0.48 |
88 | 149 | 4z0c (A) | 398 | 457 | 38.00 | 0.27 | 0.67 | 0.598384 | 0.04 |
269 | 326 | 2pih (A) | 63 | 120 | 28.00 | 0.96 | 0.02 | 0.513114 | -0.58 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128407)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09760 | U2 small nuclear ribonucleoprotein A' |
Babesia bovis | BBOV_IV006230 | U2 small nuclear ribonucleoprotein A', putative |
Brugia malayi | Bm1_15860 | U2 small nuclear ribonucleoprotein A' |
Candida albicans | CaO19.8845 | similar to U2AsnRNP A' protein |
Candida albicans | CaO19.1260 | similar to U2AsnRNP A' protein |
Caenorhabditis elegans | CELE_H20J04.8 | Protein MOG-2 |
Cryptosporidium hominis | Chro.30327 | hypothetical protein |
Cryptosporidium parvum | cgd3_2880 | U2 small nuclear ribonucleoprotein A like LRR repeats |
Dictyostelium discoideum | DDB_G0284101 | U2 small nuclear ribonucleoprotein A' |
Drosophila melanogaster | Dmel_CG1406 | CG1406 gene product from transcript CG1406-RA |
Echinococcus granulosus | EgrG_000164800 | centrosomal protein of 97 kda |
Echinococcus granulosus | EgrG_000378600 | u2 small nuclear ribonucleoprotein A' |
Echinococcus multilocularis | EmuJ_000378600 | u2 small nuclear ribonucleoprotein A' |
Echinococcus multilocularis | EmuJ_000164800 | centrosomal protein of 97 kda |
Homo sapiens | ENSG00000131876 | small nuclear ribonucleoprotein polypeptide A' |
Leishmania braziliensis | LbrM.32.0240 | U2 small nuclear ribonucleoprotein 40K, putative |
Leishmania donovani | LdBPK_320180.1 | U2 small nuclear ribonucleoprotein 40K, putative |
Leishmania infantum | LinJ.32.0180 | U2 small nuclear ribonucleoprotein 40K, putative |
Leishmania major | LmjF.32.0170 | U2 small nuclear ribonucleoprotein 40K, putative |
Leishmania mexicana | LmxM.31.0170 | U2 small nuclear ribonucleoprotein 40K, putative |
Loa Loa (eye worm) | LOAG_05924 | U2 small nuclear ribonucleoprotein A |
Mus musculus | ENSMUSG00000030512 | small nuclear ribonucleoprotein polypeptide A' |
Neospora caninum | NCLIV_030140 | U2 small nuclear ribonucleoprotein, putative |
Oryza sativa | 4328823 | Os02g0234800 |
Plasmodium berghei | PBANKA_1145700 | U2 small nuclear ribonucleoprotein A', putative |
Plasmodium falciparum | PF3D7_1369700 | U2 small nuclear ribonucleoprotein A', putative |
Plasmodium knowlesi | PKNH_1101500 | U2 small nuclear ribonucleoprotein A', putative |
Plasmodium yoelii | PY01144 | Leucine Rich Repeat, putative |
Saccharomyces cerevisiae | YPL213W | Lea1p |
Schistosoma mansoni | Smp_101640 | U2 small nuclear ribonucleoprotein A |
Schmidtea mediterranea | mk4.009618.02 | Probable U2 small nuclear ribonucleoprotein A' |
Trypanosoma brucei gambiense | Tbg972.10.17450 | U2 small nuclear ribonucleoprotein 40K, putative |
Trypanosoma brucei | Tb927.10.14360 | U2 small nuclear ribonucleoprotein 40K |
Trypanosoma cruzi | TcCLB.511283.190 | U2 small nuclear ribonucleoprotein 40K, putative |
Toxoplasma gondii | TGME49_229210 | small nuclear ribonucleoprotein polypeptide A', putative |
Theileria parva | TP01_0432 | U2 small nuclear ribonucleoprotein A, putative |
Trichomonas vaginalis | TVAG_244900 | U2 small nuclear ribonucleoprotein A, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14360 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14360 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14360 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14360 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H20J04.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H20J04.8 | Caenorhabditis elegans | sterile | wormbase |
YPL213W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_229210 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.