Detailed view for PF3D7_1138600

Basic information

TDR Targets ID: 1865
Plasmodium falciparum, beta-catenin-like protein 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.5487 | Length (AA): 527 | MW (Da): 62419 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08216   Catenin-beta-like, Arm-motif containing nuclear

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  
GO:0005488   binding  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 522 4hm9 (A) 50 562 24.00 0 1 1.08152 -0.61
28 172 2z6g (A) 528 678 14.00 0.000000000028 0.93 0.579442 -1.29
143 301 3hcw (A) 74 257 30.00 0.12 0.25 0.114708 1.94

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile early trophozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129481)

Species Accession Gene Product
Arabidopsis thaliana AT3G02710   mRNA splicing-related protein
Babesia bovis BBOV_III005350   hypothetical protein
Caenorhabditis elegans CELE_M01E11.2   Protein M01E11.2
Cryptosporidium hominis Chro.50473   hypothetical protein
Cryptosporidium parvum cgd5_3800   hypothetical protein
Dictyostelium discoideum DDB_G0292778   armadillo-like helical domain-containing protein
Drosophila melanogaster Dmel_CG11964   CG11964 gene product from transcript CG11964-RA
Echinococcus granulosus EgrG_000926800   beta catenin protein 1
Echinococcus multilocularis EmuJ_000926800   beta catenin protein 1
Homo sapiens ENSG00000132792   catenin, beta like 1
Mus musculus ENSMUSG00000027649   catenin, beta like 1
Neospora caninum NCLIV_000690   hypothetical protein
Oryza sativa 4331250   Os02g0831300
Plasmodium berghei PBANKA_0910100   beta-catenin-like protein 1, putative
Plasmodium falciparum PF3D7_1138600   beta-catenin-like protein 1, putative
Plasmodium knowlesi PKNH_0936800   beta-catenin-like protein 1, putative
Plasmodium yoelii PY06844   hypothetical protein
Schistosoma japonicum Sjp_0117390   expressed protein
Schistosoma japonicum Sjp_0099590   expressed protein
Schistosoma japonicum Sjp_0076050   expressed protein
Schistosoma japonicum Sjp_0066870   IPR013180,Protein of unknown function DUF1716, eukaryotic,domain-containing
Schistosoma japonicum Sjp_0004290   Beta-catenin-like protein 1, putative
Schistosoma japonicum Sjp_0122950   expressed protein
Schistosoma japonicum Sjp_0077710   IPR013180,Protein of unknown function DUF1716, eukaryotic,domain-containing
Schistosoma japonicum Sjp_0217110   Beta-catenin-like protein 1, putative
Schistosoma japonicum Sjp_0084800   Beta-catenin-like protein 1, putative
Schistosoma japonicum Sjp_0117540   Beta-catenin-like protein 1, putative
Schistosoma japonicum Sjp_0090460   expressed protein
Schistosoma japonicum Sjp_0315250   IPR013180,Protein of unknown function DUF1716, eukaryotic,domain-containing
Schistosoma mansoni Smp_089400   hypothetical protein
Schmidtea mediterranea mk4.003810.00  
Schmidtea mediterranea mk4.000231.05   Beta-catenin-like protein 1
Toxoplasma gondii TGME49_239930   beta-catenin family protein 1, putative
Theileria parva TP02_0413   hypothetical protein
Trichomonas vaginalis TVAG_013840   conserved hypothetical protein

Essentiality

PF3D7_1138600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0910100 Plasmodium berghei Slow plasmo
TGME49_239930 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1138600 (Plasmodium falciparum), beta-catenin-like protein 1, putative
Title for this comment
Comment