Detailed view for Tb927.8.4980

Basic information

TDR Targets ID: 18678
Trypanosoma brucei, Paraflagellar rod protein 2-2
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.8919 | Length (AA): 600 | MW (Da): 69597 | Paralog Number: 9

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05149   Paraflagellar rod protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0043056   forward locomotion  
GO:0031514   motile secondary cilium  
GO:0019861   flagellum  
GO:0006928   cell motility  
GO:0003674   molecular_function  
GO:0009434   microtubule-based flagellum  
GO:0005856   cytoskeleton  
GO:0005516   calmodulin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130385)

Species Accession Gene Product
Leishmania braziliensis LbrM.16.1480   paraflagellar rod protein 2C
Leishmania braziliensis LbrM.31.0160   paraflagellar rod protein 1D
Leishmania braziliensis LbrM.16.1490   paraflagellar rod protein 2C
Leishmania donovani LdBPK_291890.1   paraflagellar rod protein 1D, putative
Leishmania donovani LdBPK_161510.1   paraflagellar rod protein 2C
Leishmania infantum LinJ.16.1510   paraflagellar rod protein 2C
Leishmania infantum LinJ.29.1890   paraflagellar rod protein 1D, putative
Leishmania infantum LinJ.16.1520   paraflagellar rod protein 2C
Leishmania infantum LinJ.29.1880   paraflagellar rod protein 1D, putative
Leishmania major LmjF.29.1760   paraflagellar rod protein 1D, putative
Leishmania major LmjF.16.1427   paraflagellar rod protein 2C
Leishmania major LmjF.16.1425   paraflagellar rod protein 2C
Leishmania major LmjF.29.1770   paraflagellar rod protein 1D, putative
Leishmania major LmjF.16.1430   paraflagellar rod protein 2C
Leishmania major LmjF.29.1750   paraflagellar rod protein 1D, putative
Leishmania mexicana LmxM.08_29.1760   paraflagellar rod protein 1D, putative
Leishmania mexicana LmxM.16.1430   paraflagellar rod protein 2C
Leishmania mexicana LmxM.08_29.1750   paraflagellar rod protein 1D, putative
Trypanosoma brucei gambiense Tbg972.8.4790   69 kDa paraflagellar rod protein
Trypanosoma brucei gambiense Tbg972.3.4730   73 kDa paraflagellar rod protein,PFR1
Trypanosoma brucei gambiense Tbg972.3.4720   73 kDa paraflagellar rod protein,PFR1
Trypanosoma brucei gambiense Tbg972.8.4800   69 kDa paraflagellar rod protein
Trypanosoma brucei Tb927.8.5000   Paraflagellar rod protein 2-4
Trypanosoma brucei Tb927.8.4970   Paraflagellar rod protein 2-1
Trypanosoma brucei Tb927.3.4330   Paraflagellar rod protein 1-5
Trypanosoma brucei Tb927.3.4290   Paraflagellar rod protein 1-1
Trypanosoma brucei Tb11.v5.0538   69 kDa paraflagellar rod protein, putative
Trypanosoma brucei Tb927.3.4310   Paraflagellar rod protein 1-3
Trypanosoma brucei Tb927.3.4300   Paraflagellar rod protein 1-2
Trypanosoma brucei Tb927.3.4320   Paraflagellar rod protein 1-4
Trypanosoma brucei Tb927.8.4990   Paraflagellar rod protein 2-3
Trypanosoma brucei Tb927.8.4980   Paraflagellar rod protein 2-2
Trypanosoma congolense TcIL3000_8_4760   PFR2, putative
Trypanosoma congolense TcIL3000_8_4750   73 kDa paraflagellar rod protein, putative
Trypanosoma cruzi TcCLB.511215.119   Paraflagellar rod protein 2
Trypanosoma cruzi TcCLB.434931.10   paraxonemal rod protein PAR2, putative
Trypanosoma cruzi TcCLB.509617.20   paraflagellar rod protein 3, putative

Essentiality

Tb927.8.4980 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.4970 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.8.4970 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.4970 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.4970 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.3.4290 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.4290 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.4290 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.4290 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Tb927.8.4980 (Trypanosoma brucei), Paraflagellar rod protein 2-2
Title for this comment
Comment