Detailed view for PF3D7_1138800

Basic information

TDR Targets ID: 1868
Plasmodium falciparum, WD repeat-containing protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.3013 | Length (AA): 1920 | MW (Da): 222078 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 20 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 311 1got (B) 42 340 14.00 0 0.18 1 -0.24
47 313 1got (B) 70 340 14.00 0 0.32 0.92 -0.54
62 275 2h14 (A) 32 332 15.00 0 0.94 0.34 0.06
5 209 4psj (A) 43 250 15.00 0.56 0.02 0.227371 -0.27
435 596 4r58 (A) 38 219 24.00 0.012 0.82 0.239875 -0.05
941 1070 4tql (A) 45 190 32.00 0.78 0.04 0.419208 -1.89
958 1685 3vkg (A) 3272 4223 16.00 0.9 1 0.398767 0.72
1291 1416 2j49 (A) 149 277 22.00 0.012 0.84 0.399225 -1.08
1578 1916 3v7d (B) 391 730 17.00 0.0000000000055 1 0.119162 0.69
1593 1913 3sfz (A) 597 950 17.00 0 0.87 0.199787 0.56
5 209 4psj (A) 43 250 14.00 0.85 0.05 0.231394 -0.41
21 230 1i5p (A) 407 629 28.00 0.19 0.02 0.227003 0.33
441 614 4r58 (A) 38 218 22.00 0.028 0.83 0.354214 -0.22
963 1170 4tql (A) 23 236 16.00 0.17 0.01 0.26096 -1.13
1024 1286 3uau (A) 56 346 30.00 0.29 0.05 0.124665 1.16
1287 1412 2j49 (A) 149 277 21.00 0.036 0.62 0.382162 -1.06
1531 1824 4nsx (A) 363 673 18.00 0.0000082 1 0.323845 0.08
1589 1909 3sfz (A) 597 950 17.00 0 0.87 0.196937 0.56
1591 1735 4ozu (A) 63 217 17.00 0.18 0.33 0.197078 -0.2
1599 1911 4wjs (A) 140 506 15.00 0 1 0.0377612 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, sporozoite, early ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, merozoite, early schizont, early trophozoite, late ring, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, late schizont, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_150004)

Species Accession Gene Product
Plasmodium berghei PBANKA_0909900   WD repeat-containing protein, putative
Plasmodium falciparum PF3D7_1138800   WD repeat-containing protein, putative
Plasmodium knowlesi PKNH_0937000   WD repeat-containing protein, putative
Plasmodium vivax PVX_092555   WD domain, G-beta repeat domain containing protein
Plasmodium yoelii PY05176   ERYTHROCYTE MEMBRANE PROTEIN PFEMP3
Plasmodium yoelii PY07202   PCAF associated factor 65 beta
Theileria parva TP01_0533   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1138800 (Plasmodium falciparum), WD repeat-containing protein, putative
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