pI: 5.0728 |
Length (AA): 178 |
MW (Da): 19881 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 178 | 2x77 (A) | 12 | 182 | 45.00 | 0 | 1 | 1.6415 | -1.4 |
2 | 176 | 1fzq (A) | 2 | 177 | 58.00 | 0 | 1 | 1.85265 | -1.98 |
12 | 177 | 3lvq (E) | 678 | 174 | 42.00 | 0.00022 | 1 | 1.62678 | -2.09 |
15 | 177 | 1upt (A) | 16 | 178 | 44.00 | 0.0000014 | 1 | 1.63293 | -2.12 |
18 | 178 | 5de3 (A) | 18 | 178 | 60.00 | 0 | 1 | 1.76989 | -1.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_130091)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_39945 | ADP-ribosylation factor-like protein 3 |
Caenorhabditis elegans | CELE_F19H8.3 | Protein ARL-3 |
Drosophila melanogaster | Dmel_CG6560 | dead end |
Giardia lamblia | GL50803_13478 | ARL1 |
Homo sapiens | ENSG00000138175 | ADP-ribosylation factor-like 3 |
Leishmania braziliensis | LbrM.35.6550 | ADP ribosylation factor 3, putative |
Leishmania braziliensis | LbrM.29.0940 | ADP ribosylation factor 3, putative |
Leishmania donovani | LdBPK_366490.1 | ADP-ribosylation factor-like protein 3b, putative |
Leishmania donovani | LdBPK_290950.1 | ADP-ribosylation factor-like protein 3A, putative |
Leishmania infantum | LinJ.36.6490 | ADP ribosylation factor 3, putative |
Leishmania infantum | LinJ.29.0950 | ADP ribosylation factor 3, putative |
Leishmania major | LmjF.36.6230 | ADP ribosylation factor 3, putative |
Leishmania major | LmjF.29.0880 | ADP ribosylation factor 3, putative |
Leishmania mexicana | LmxM.08_29.0880 | ADP ribosylation factor 3, putative |
Leishmania mexicana | LmxM.36.6230 | ADP ribosylation factor 3, putative |
Loa Loa (eye worm) | LOAG_11439 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04492 | hypothetical protein |
Mus musculus | ENSMUSG00000025035 | ADP-ribosylation factor-like 3 |
Schistosoma japonicum | Sjp_0060570 | ko:K07944 ADP-ribosylation factor-like 3, putative |
Schistosoma mansoni | Smp_159930 | ADP-ribosylation factor-like 3 arl3 |
Schmidtea mediterranea | mk4.004973.00 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.001485.00 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.000672.03 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.001865.01 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.002854.06 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.007512.00 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.018954.01 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.000074.11 | ADP-ribosylation factor-like protein 3 |
Schmidtea mediterranea | mk4.003897.01 | ADP-ribosylation factor-like protein 3 |
Trypanosoma brucei gambiense | Tbg972.3.3690 | ADP-ribosylation factor-like protein 3A, putative |
Trypanosoma brucei | Tb927.3.3450 | ADP-ribosylation factor-like protein 3, putative |
Trypanosoma congolense | TcIL3000_3_2160 | ADP-ribosylation factor-like protein 3, putative |
Trypanosoma cruzi | TcCLB.507951.170 | ADP-ribosylation factor-like protein 3, putative |
Trypanosoma cruzi | TcCLB.504433.10 | ADP-ribosylation factor-like protein 3, putative |
Trichomonas vaginalis | TVAG_433430 | ADP-ribosylation factor, arf, putative |
Trichomonas vaginalis | TVAG_120630 | ADP-ribosylation factor, arf, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.3450 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.3450 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.3450 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.3450 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.