pI: 9.4424 |
Length (AA): 219 |
MW (Da): 25956 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
157 | 188 | 3n4p (B) | 477 | 512 | 41.00 | 0.46 | 0.05 | 0.158819 | 3.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127279)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G25040 | ER retention receptor ERD2b |
Arabidopsis thaliana | AT1G29330 | ER lumen protein retaining receptor |
Babesia bovis | BBOV_III009160 | ER lumen protein retaining receptor |
Brugia malayi | Bm1_37730 | ER lumen protein retaining receptor |
Brugia malayi | Bm1_52975 | ER lumen protein retaining receptor |
Candida albicans | CaO19.10270 | receptor for ER-retention signal |
Candida albicans | CaO19.2756 | receptor for ER-retention signal |
Caenorhabditis elegans | CELE_C28H8.4 | Protein C28H8.4 |
Caenorhabditis elegans | CELE_F09B9.3 | Protein ERD-2 |
Cryptosporidium hominis | Chro.80131 | endoplasmic reticulum retention receptor |
Cryptosporidium parvum | cgd8_1110 | ER/lumen protein retaining receptor (KDEL receptor), signal peptide plus 4 or more transmembrane domains |
Dictyostelium discoideum | DDB_G0272124 | ER lumen protein retaining receptor |
Drosophila melanogaster | Dmel_CG5183 | KDEL receptor |
Echinococcus granulosus | EgrG_001117400 | ER lumen protein retaining receptor |
Echinococcus granulosus | EgrG_000131100 | ER lumen protein retaining receptor |
Entamoeba histolytica | EHI_170470 | ER lumen protein retaining receptor |
Echinococcus multilocularis | EmuJ_000131100 | ER lumen protein retaining receptor |
Echinococcus multilocularis | EmuJ_001117400 | ER lumen protein retaining receptor |
Giardia lamblia | GL50803_4502 | ER lumen protein retaining receptor |
Homo sapiens | ENSG00000136240 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 |
Homo sapiens | ENSG00000105438 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
Leishmania braziliensis | LbrM.28.0650 | ER lumen retaining receptor-like protein |
Leishmania donovani | LdBPK_280670.1 | ER lumen retaining receptor-like protein |
Leishmania infantum | LinJ.28.0670 | ER lumen retaining receptor-like protein |
Leishmania major | LmjF.28.0630 | ER lumen retaining receptor-like protein |
Leishmania mexicana | LmxM.28.0630 | ER lumen retaining receptor-like protein |
Loa Loa (eye worm) | LOAG_04271 | ER lumen protein retaining receptor |
Loa Loa (eye worm) | LOAG_01978 | ER lumen protein retaining receptor |
Mus musculus | ENSMUSG00000079111 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 |
Mus musculus | ENSMUSG00000002778 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
Neospora caninum | NCLIV_068650 | endoplasmic reticulum retention receptor, putative |
Neospora caninum | NCLIV_029080 | hypothetical protein |
Oryza sativa | 4350496 | Os11g0473000 |
Oryza sativa | 4339403 | Os05g0529300 |
Oryza sativa | 4335613 | Os04g0376700 |
Plasmodium berghei | PBANKA_1130200 | ER lumen protein retaining receptor, putative |
Plasmodium falciparum | PF3D7_1353600 | ER lumen protein retaining receptor |
Plasmodium knowlesi | PKNH_1118100 | ER lumen protein retaining receptor, putative |
Plasmodium vivax | PVX_114670 | ER lumen protein retaining receptor, putative |
Plasmodium yoelii | PY05552 | er lumen protein retaining receptor-related |
Saccharomyces cerevisiae | YBL040C | Erd2p |
Schistosoma japonicum | Sjp_0205660 | ER lumen protein retaining receptor, putative |
Schistosoma japonicum | Sjp_0305510 | ER lumen protein retaining receptor 2, putative |
Schistosoma mansoni | Smp_154160 | ER lumen protein retaining receptor |
Schistosoma mansoni | Smp_007730.3 | ER lumen protein retaining receptor |
Schistosoma mansoni | Smp_007730.2 | ER lumen protein retaining receptor |
Schistosoma mansoni | Smp_007730.1 | ER lumen protein retaining receptor |
Schmidtea mediterranea | mk4.001258.01 | ER lumen protein retaining receptor |
Schmidtea mediterranea | mk4.003522.01 | ER lumen protein-retaining receptor 3 |
Schmidtea mediterranea | mk4.001328.00 | ER lumen protein-retaining receptor |
Trypanosoma brucei gambiense | Tbg972.11.9300 | ER lumen retaining receptor protein, putative |
Trypanosoma brucei | Tb927.11.8140 | ER lumen retaining receptor protein, putative |
Trypanosoma congolense | TcIL3000.11.8670 | ER lumen retaining receptor protein, putative |
Trypanosoma cruzi | TcCLB.508815.160 | ER lumen retaining receptor protein, putative |
Toxoplasma gondii | TGME49_256000 | endoplasmic reticulum retention receptor |
Toxoplasma gondii | TGME49_276910 | endoplasmic reticulum lumen protein retaining receptor (ERD2) family protein |
Theileria parva | TP04_0824 | ER lumen protein retaining receptor, putative |
Trichomonas vaginalis | TVAG_242900 | er lumen protein retaining receptor, putative |
Trichomonas vaginalis | TVAG_040450 | er lumen protein retaining receptor, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.0410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.0410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.0410 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.0410 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F09B9.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C28H8.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
YBL040C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1130200 | Plasmodium berghei | Essential | plasmo |
TGME49_276910 | Toxoplasma gondii | Probably essential | sidik |
TGME49_256000 | Toxoplasma gondii | Probably essential | sidik |
TGME49_276910 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_256000 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
1 literature reference was collected for this gene.