pI: 11.9029 |
Length (AA): 202 |
MW (Da): 23811 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127368)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G48830 | 40S ribosomal protein S7-1 |
Arabidopsis thaliana | AT5G16130 | 40S ribosomal protein S7-3 |
Arabidopsis thaliana | AT3G02560 | 40S ribosomal protein S7-2 |
Babesia bovis | BBOV_III009350 | ribosomal protein S7e family protein |
Brugia malayi | Bm1_09900 | 40S ribosomal protein S7 |
Candida albicans | CaO19.1700 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS7A (YOR096W) and RPS7B (YNL096C) small subunit protein S7 |
Candida albicans | CaO19.9267 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS7A (YOR096W) and RPS7B (YNL096C) small subunit protein S7 |
Caenorhabditis elegans | CELE_ZC434.2 | Protein RPS-7 |
Cryptosporidium hominis | Chro.50070 | 40S ribosomal protein S7 |
Cryptosporidium parvum | cgd5_3040 | 40S ribosomal protein S7 |
Dictyostelium discoideum | DDB_G0289025 | 40S ribosomal protein S7 |
Drosophila melanogaster | Dmel_CG1883 | Ribosomal protein S7 |
Echinococcus granulosus | EgrG_000844100 | expressed protein |
Entamoeba histolytica | EHI_140540 | 40S ribosomal protein S7, putative |
Entamoeba histolytica | EHI_067530 | 40S ribosomal protein S7, putative |
Echinococcus multilocularis | EmuJ_000844100 | expressed protein |
Giardia lamblia | GL50803_14329 | Ribosomal protein S7 |
Homo sapiens | ENSG00000171863 | ribosomal protein S7 |
Leishmania braziliensis | LbrM.01.0460 | ribosomal protein S7, putative |
Leishmania braziliensis | LbrM.01.0470 | ribosomal protein S7, putative |
Leishmania donovani | LdBPK_010440.1 | ribosomal protein S7, putative |
Leishmania infantum | LinJ.01.0440 | ribosomal protein S7, putative |
Leishmania infantum | LinJ.01.0430 | ribosomal protein S7, putative |
Leishmania major | LmjF.01.0410 | ribosomal protein S7, putative |
Leishmania major | LmjF.01.0420 | ribosomal protein S7, putative |
Leishmania mexicana | LmxM.01.0410 | |
Loa Loa (eye worm) | LOAG_13113 | 40S ribosomal protein S7 |
Mus musculus | 102638448 | 40S ribosomal protein S7-like |
Mus musculus | ENSMUSG00000061477 | ribosomal protein S7 |
Neospora caninum | NCLIV_015880 | hypothetical protein |
Oryza sativa | 4338485 | Os05g0346300 |
Oryza sativa | 4332545 | Os03g0297100 |
Plasmodium berghei | PBANKA_1401300 | 40S ribosomal protein S7, putative |
Plasmodium falciparum | PF3D7_1302800 | 40S ribosomal protein S7, putative |
Plasmodium knowlesi | PKNH_1403000 | 40S ribosomal protein S7, putative |
Plasmodium vivax | PVX_121980 | 40S ribosomal protein S7, putative |
Plasmodium yoelii | PY03900 | Ribosomal protein S7e |
Saccharomyces cerevisiae | YNL096C | ribosomal 40S subunit protein S7B |
Saccharomyces cerevisiae | YOR096W | ribosomal 40S subunit protein S7A |
Schistosoma japonicum | Sjp_0043930 | ko:K02993 small subunit ribosomal protein S7e, putative |
Schistosoma mansoni | Smp_021140 | ribosomal protein S7 |
Schmidtea mediterranea | mk4.004251.01 | 40S ribosomal protein S7 |
Schmidtea mediterranea | mk4.006585.01 | 40S ribosomal protein S7 |
Trypanosoma brucei gambiense | Tbg972.9.2080 | ribosomal protein S7, putative |
Trypanosoma brucei | Tb927.9.3990 | ribosomal protein S7, putative |
Trypanosoma brucei | Tb927.9.3920 | ribosomal protein S7, putative |
Trypanosoma congolense | TcIL3000_0_19490 | ribosomal protein S7, putative |
Trypanosoma congolense | TcIL3000_9_1270 | ribosomal protein S7, putative |
Trypanosoma cruzi | TcCLB.506593.30 | ribosomal protein S7, putative |
Trypanosoma cruzi | TcCLB.506593.19 | ribosomal protein S7, putative |
Trypanosoma cruzi | TcCLB.506829.39 | ribosomal protein S7, putative |
Toxoplasma gondii | TGME49_239100 | ribosomal protein RPS7 |
Theileria parva | TP04_0844 | 40S ribosomal protein S7, putative |
Trichomonas vaginalis | TVAG_143030 | 40S ribosomal protein S7, putative |
Trichomonas vaginalis | TVAG_198680 | 40S ribosomal protein S7, putative |
Trichomonas vaginalis | TVAG_375490 | 40S ribosomal protein S7, putative |
Trichomonas vaginalis | TVAG_199100 | 40S ribosomal protein S7, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.2490 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.2490 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.2490 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.2490 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_ZC434.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZC434.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZC434.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_ZC434.2 | Caenorhabditis elegans | sterile | wormbase |
CELE_ZC434.2 | Caenorhabditis elegans | terminal arrest variable | wormbase |
PBANKA_1401300 | Plasmodium berghei | Essential | plasmo |
TGME49_239100 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.