Detailed view for PF3D7_1355700

Basic information

TDR Targets ID: 190
Plasmodium falciparum, NLI interacting factor-like phosphatase, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.8527 | Length (AA): 1288 | MW (Da): 151546 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03031   NLI interacting factor-like phosphatase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
830 1058 1ta0 (A) 79 256 22.00 0 0.9 0.06 -0.44
845 1017 1ta0 (A) 87 246 21.00 0.000053 0.76 0.36 -0.75
27 139 3ult (A) 6 114 29.00 0.052 0.41 0.396833 -0.6
71 391 4o87 (A) 31 311 29.00 0.0039 0.17 0.258324 0.66
72 326 3ren (A) 95 361 20.00 0.51 0.73 0.431081 -0.32
844 1145 4xpz (A) 161 500 32.00 0 1 0.395572 -0.13
1074 1163 4id3 (A) 165 250 14.00 0.093 0.1 0.183676 -0.47
1105 1288 4uos (A) 2 184 11.00 0.28 0.01 0.323657 -1.06
14 98 3ult (A) 12 115 32.00 0.012 0.27 0.222488 -0.41
190 435 1fyh (A) 9 299 30.00 0.34 0.29 0.193908 0.44
429 748 4wat (A) 146 509 10.00 0.58 0.01 0.305695 -0.24
649 842 1f1s (A) 271 455 25.00 0.99 0.59 0.343723 -0.16
849 1021 2ght (A) 86 243 20.00 0.0000013 0.86 0.265094 0.18
850 1151 4xpz (A) 161 500 32.00 0 1 0.395185 -0.13
1080 1169 4id3 (A) 165 250 14.00 0.17 0.1 0.179952 -0.47
1122 1293 4uos (A) 2 179 11.00 0.071 0.01 0.317221 -1.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, merozoite, sporozoite, early ring, early trophozoite, late ring. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early schizont, late schizont, late trophozoite, Ring, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, gametocyte, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, Oocyst. Otto TD Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_134228)

Species Accession Gene Product
Arabidopsis thaliana AT3G17550   putative phosphoprotein phosphatase
Arabidopsis thaliana AT5G23470   haloacid dehalogenase-like hydrolase superfamily protein
Arabidopsis thaliana AT2G04930   haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT1G43600   Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT2G02290   Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT3G19595   Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT5G54210   haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT1G20320   haloacid dehalogenase-like hydrolase
Arabidopsis thaliana AT3G19600   Ser-2-specific RNAPII CTD phosphatase
Arabidopsis thaliana AT1G43610   Haloacid dehalogenase-like hydrolase superfamily protein
Babesia bovis BBOV_IV000150   hypothetical protein
Cryptosporidium hominis Chro.70469   NLI interacting factor
Cryptosporidium parvum cgd7_4250   RNA pol II carboxy terminal domain phosphatase of the HAD superfamily with a BRCT domain at the C-terminus
Dictyostelium discoideum DDB_G0288707   hypothetical protein
Neospora caninum NCLIV_036820   hypothetical protein
Plasmodium berghei PBANKA_1132000   NLI interacting factor-like phosphatase
Plasmodium falciparum PF3D7_1355700   NLI interacting factor-like phosphatase, putative
Plasmodium knowlesi PKNH_1115800   NLI interacting factor-like phosphatase, putative
Plasmodium vivax PVX_114760   NLI interacting factor-like phosphatase, putative
Plasmodium yoelii PY04698   NLI interacting factor, putative
Toxoplasma gondii TGME49_269700   NLI interacting factor family phosphatase
Theileria parva TP02_0943   hypothetical protein

Essentiality

PF3D7_1355700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1132000 Plasmodium berghei Essential plasmo
TGME49_269700 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1355700 (Plasmodium falciparum), NLI interacting factor-like phosphatase, putative
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