pI: 5.8534 |
Length (AA): 595 |
MW (Da): 64566 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
31 | 537 | 5uju (A) | 1 | 538 | 23.00 | 0.0000025 | 1 | 0.971801 | 0.51 |
46 | 524 | 3u4j (A) | 5 | 482 | 33.00 | 0 | 1 | 1.23674 | -0.51 |
78 | 526 | 1a4s (A) | 37 | 484 | 30.00 | 0 | 1 | 1.11502 | -0.37 |
86 | 535 | 3iwj (A) | 32 | 486 | 35.00 | 0 | 1 | 1.159 | -0.32 |
86 | 535 | 3iwk (A) | 32 | 486 | 34.00 | 0 | 1 | 1.204 | -0.67 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_131364)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G66658 | aldehyde dehydrogenase 22A1 |
Candida albicans | CaO19.9421 | similarity to aldehyde dehydrogenase |
Candida albicans | CaO19.1865 | similarity to aldehyde dehydrogenase |
Dictyostelium discoideum | DDB_G0279613 | aldehyde dehydrogenase |
Leishmania braziliensis | LbrM.30.2880 | aldehyde dehydrogenase, putative |
Leishmania donovani | LdBPK_302920.1 | aldehyde dehydrogenase, putative |
Leishmania infantum | LinJ.30.2920 | aldehyde dehydrogenase, putative |
Leishmania major | LmjF.30.2900 | aldehyde dehydrogenase, putative |
Leishmania mexicana | LmxM.29.2900 | aldehyde dehydrogenase, putative |
Oryza sativa | 9268600 | Os07g0689150 |
Oryza sativa | 4344358 | Os07g0688800 |
Saccharomyces cerevisiae | YHR039C | Msc7p |
Trypanosoma brucei gambiense | Tbg972.6.4000 | aldehyde dehydrogenase, putative |
Trypanosoma brucei | Tb927.6.4210 | aldehyde dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.506943.4 | aldehyde dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4210 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4210 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4210 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4210 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Aldehyde dehydrogenase 1A1 | 501 aa | 33.5% | 439 aa | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase | 519 aa | 31.3% | 451 aa | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase, cytosolic 1 | 501 aa | 33.8% | 441 aa | Compounds | References |
1 literature reference was collected for this gene.