pI: 6.4803 |
Length (AA): 207 |
MW (Da): 23610 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 144 | 1yzq (A) | 34 | 177 | 72.00 | 0 | 1 | 1.72 | -1.26 |
1 | 170 | 2bcg (Y) | 29 | 196 | 39.00 | 0 | 1 | 1.45 | -0.41 |
1 | 141 | 1d5c (A) | 32 | 172 | 99.00 | 0 | 1 | 1.99 | -1.14 |
11 | 172 | 1d5c (A) | 11 | 172 | 99.00 | 0 | 1 | 2.05261 | -1.91 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, late schizont, Oocyst, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 8 hs, late trophozoite, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | early trophozoite. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | gametocyte. | PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_127256)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G44610 | Ras-related protein RABH1B |
Arabidopsis thaliana | AT5G10260 | ras-related protein RABH1e |
Arabidopsis thaliana | AT2G22290 | RAB GTPase-like protein H1D |
Arabidopsis thaliana | AT4G39890 | Ras-related protein RABH1c |
Babesia bovis | BBOV_III004450 | Ras family protein |
Brugia malayi | Bm1_32095 | Ras-related protein Rab-6B |
Brugia malayi | Bm1_32085 | rab6 |
Candida albicans | CaO19.8333 | similar to S. cerevisiae VPT6 (YLR262C) rab family GTP-binding protein |
Candida albicans | CaO19.714 | similar to S. cerevisiae VPT6 (YLR262C) rab family GTP-binding protein |
Caenorhabditis elegans | CELE_F59B2.7 | Protein RAB-6.1 |
Caenorhabditis elegans | CELE_T25G12.4 | Protein RAB-6.2 |
Cryptosporidium parvum | cgd2_1940 | RAB6 protein, putative |
Dictyostelium discoideum | DDB_G0268068 | Rab GTPase |
Drosophila melanogaster | Dmel_CG6601 | CG6601 gene product from transcript CG6601-RB |
Echinococcus granulosus | EgrG_000373050 | RAB6A member RAS oncogene family |
Entamoeba histolytica | EHI_014060 | Rab family GTPase |
Entamoeba histolytica | EHI_157890 | Rab family GTPase |
Echinococcus multilocularis | EmuJ_000373050 | RAB6A, member RAS oncogene family |
Homo sapiens | ENSG00000175582 | RAB6A, member RAS oncogene family |
Homo sapiens | ENSG00000154917 | RAB6B, member RAS oncogene family |
Leishmania braziliensis | LbrM.02.0290 | small GTP binding protein rab6-like protein |
Leishmania donovani | LdBPK_020230.1 | small GTP binding protein rab6-like protein |
Leishmania infantum | LinJ.02.0230 | small GTP binding protein rab6-like protein |
Leishmania major | LmjF.02.0260 | small GTP binding protein rab6-like protein |
Leishmania mexicana | LmxM.02.0260 | small GTP binding protein rab6-like protein |
Loa Loa (eye worm) | LOAG_03709 | Rab6A |
Loa Loa (eye worm) | LOAG_03707 | hypothetical protein |
Mus musculus | ENSMUSG00000030704 | RAB6A, member RAS oncogene family |
Mus musculus | ENSMUSG00000032549 | RAB6B, member RAS oncogene family |
Neospora caninum | NCLIV_054540 | RAB5C, member RAS oncogene family, related |
Oryza sativa | 4343293 | Os07g0496000 |
Plasmodium berghei | PBANKA_0904100 | ras-related protein Rab-6 |
Plasmodium falciparum | PF3D7_1144900 | ras-related protein Rab-6 |
Plasmodium knowlesi | PKNH_0942800 | ras-related protein Rab-6, putative |
Plasmodium vivax | PVX_092850 | ras-related protein Rab-6, putative |
Plasmodium yoelii | PY00721 | Rab6 |
Saccharomyces cerevisiae | YLR262C | Rab family GTPase YPT6 |
Schistosoma japonicum | Sjp_0019960 | ko:K07976 Rab family, other, putative |
Schistosoma mansoni | Smp_163580 | rab6 |
Schmidtea mediterranea | mk4.005399.05 | Ras-related protein Rab6 |
Schmidtea mediterranea | mk4.008220.00 | Ras-related protein Rab6 |
Schmidtea mediterranea | mk4.005670.02 | Ras-related protein Rab6 |
Schmidtea mediterranea | mk4.005399.03 | Ras-related protein Rab6 |
Trypanosoma brucei gambiense | Tbg.972.2.700 | small GTP-binding protein RAB6, putative |
Trypanosoma brucei | Tb927.2.2130 | small GTP-binding protein RAB6, putative |
Trypanosoma congolense | TcIL3000_0_54860 | small GTP-binding protein RAB6, putative |
Trypanosoma cruzi | TcCLB.505037.50 | small GTP-binding protein RAB6, putative |
Trypanosoma cruzi | TcCLB.510077.40 | small GTP-binding protein RAB6, putative |
Toxoplasma gondii | TGME49_310460 | Rab6 |
Theileria parva | TP02_0799 | GTP-binding protein rab6, putative |
Trichomonas vaginalis | TVAG_153440 | RAB, putative |
Trichomonas vaginalis | TVAG_377960 | Rab8, putative |
Trichomonas vaginalis | TVAG_297320 | small GTPase rabi, putative |
Trichomonas vaginalis | TVAG_036230 | RAB, putative |
Trichomonas vaginalis | TVAG_440690 | small GTPase rabh, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.2.2130 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.2.2130 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.2.2130 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.2.2130 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0904100 | Plasmodium berghei | Essential | plasmo |
TGME49_310460 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2