Detailed view for PF3D7_1145100

Basic information

TDR Targets ID: 1928
Plasmodium falciparum, coatomer subunit gamma, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.8445 | Length (AA): 1068 | MW (Da): 124369 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01602   Adaptin N terminal region
PF08752   Coatomer gamma subunit appendage platform subdomain
PF16381   Coatomer subunit gamma-1 C-terminal appendage platform

Gene Ontology

Mouse over links to read term descriptions.
GO:0005829   cytosol  
GO:0030126   COPI vesicle coat  
GO:0030117   membrane coat  
GO:0005798   Golgi-associated vesicle  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0005198   structural molecule activity  
GO:0016192   vesicle-mediated transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 888 1u6g (C) 43 1210 10.00 0 1 0.54 0.1
31 225 1ibr (B) 211 444 13.00 0.000000000011 0.98 0.31 -1.19
776 1067 1r4x (A) 606 873 25.00 0 1 0.38 -0.93
24 741 4uqi (B) 4 635 17.00 0 1 0.349185 0.94
34 262 3tjz (B) 23 264 48.00 0 1 0.869019 -1.31
80 213 4l7m (A) 78 213 24.00 0.45 1 0.512268 -0.96
24 740 4uqi (B) 4 635 17.00 0 1 0.346978 0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile merozoite, Oocyst, Female Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile gametocyte. PlasmoDB
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127608)

Species Accession Gene Product
Arabidopsis thaliana AT4G34450   coatomer subunit gamma
Babesia bovis BBOV_II002960   adaptin N terminal region family protein
Brugia malayi Bm1_10670   coatomer gamma subunit
Candida albicans CaO19.759   gamma-cop of secretory pathway vesicles
Candida albicans CaO19.8379   gamma-cop of secretory pathway vesicles
Caenorhabditis elegans CELE_T14G10.5   Protein T14G10.5, isoform A
Cryptosporidium hominis Chro.70219   coatomer gamma subunit
Cryptosporidium parvum cgd7_1910   coatomer SEC21 gamma subunit like (beta adaptin)
Dictyostelium discoideum DDB_G0289371   adaptin N-terminal domain-containing protein
Drosophila melanogaster Dmel_CG1528   Coat Protein (coatomer) gamma
Echinococcus granulosus EgrG_000129600   Coatomer subunit gamma
Entamoeba histolytica EHI_040700   coatomer protein gamma subunit, putative
Entamoeba histolytica EHI_012500   Coatomer gamma subunit, putative
Echinococcus multilocularis EmuJ_000129600   Coatomer subunit gamma
Homo sapiens ENSG00000181789   coatomer protein complex, subunit gamma 1
Homo sapiens ENSG00000158623   coatomer protein complex, subunit gamma 2
Leishmania braziliensis LbrM.28.2830   coatomer gamma subunit, putative
Leishmania donovani LdBPK_282820.1   Coatomer subunit gamma
Leishmania infantum LinJ.28.2820   coatomer gamma subunit, putative
Leishmania major LmjF.28.2620   coatomer gamma subunit, putative
Leishmania mexicana LmxM.28.2620   coatomer gamma subunit, putative
Loa Loa (eye worm) LOAG_07163   coatomer gamma subunit
Mus musculus ENSMUSG00000030058   coatomer protein complex, subunit gamma 1
Mus musculus ENSMUSG00000025607   coatomer protein complex, subunit gamma 2
Neospora caninum NCLIV_034270   coatomer gamma 2-subunit protein, putative
Oryza sativa 4342665   Os07g0201100
Oryza sativa 4332129   Os03g0227000
Onchocerca volvulus OVOC11480   Putative coatomer subunit gamma
Plasmodium berghei PBANKA_0903900   coatomer subunit gamma, putative
Plasmodium falciparum PF3D7_1145100   coatomer subunit gamma, putative
Plasmodium knowlesi PKNH_0943000   coatomer subunit gamma, putative
Plasmodium vivax PVX_092860   coatomer subunit gamma, putative
Plasmodium yoelii PY00718   coatomer gamma subunit
Saccharomyces cerevisiae YNL287W   Sec21p
Schistosoma japonicum Sjp_0300180   Coatomer subunit gamma-2, putative
Schistosoma mansoni Smp_092770   coatomer gamma subunit
Schmidtea mediterranea mk4.000096.05   Probable coatomer subunit gamma
Trypanosoma brucei gambiense Tbg972.11.13350   coatomer gamma subunit, putative,cytosolic coat protein, putative
Trypanosoma brucei Tb927.11.11900   Coatomer subunit gamma
Trypanosoma congolense TcIL3000.11.12560   Coatomer subunit gamma
Trypanosoma cruzi TcCLB.511211.20   Coatomer subunit gamma
Toxoplasma gondii TGME49_273370   coatomer gamma 2-subunit protein, putative
Theileria parva TP04_0297   coatomer gamma subunit, putative
Trichomonas vaginalis TVAG_103850   coatomer gamma subunit, putative

Essentiality

PF3D7_1145100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3740 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.3740 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3740 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.3740 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T14G10.5 Caenorhabditis elegans larval lethal wormbase
CELE_T14G10.5 Caenorhabditis elegans slow growth wormbase
CELE_T14G10.5 Caenorhabditis elegans sterile wormbase
YNL287W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0903900 Plasmodium berghei Slow plasmo
TGME49_273370 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1145100 (Plasmodium falciparum), coatomer subunit gamma, putative
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