pI: 10.5808 |
Length (AA): 130 |
MW (Da): 14645 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126878)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G46040 | 40S ribosomal protein S15a-4 |
Arabidopsis thaliana | AT5G59850 | 40S ribosomal protein S15a-1 |
Arabidopsis thaliana | AT1G07770 | 40S ribosomal protein S15a-1 |
Arabidopsis thaliana | AT2G39590 | 40S ribosomal protein S15a-3 |
Babesia bovis | BBOV_III010810 | ribosomal protein S8 family protein |
Brugia malayi | Bm1_48545 | 40S ribosomal protein S15a |
Candida albicans | CaO19.6265 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS22A (YJL190C) and RPS22B (YLR367W) small subunit protein S22 |
Candida albicans | CaO19.13644 | likely cytosolic ribosomal protein similar to S. cerevisiae RPS22A (YJL190C) and RPS22B (YLR367W) small subunit protein S22 |
Caenorhabditis elegans | CELE_F53A3.3 | Protein RPS-22, isoform B |
Cryptosporidium hominis | Chro.80500 | ribosomal protein S8 |
Cryptosporidium parvum | cgd8_4360 | 40S ribosomal protein S15A |
Dictyostelium discoideum | DDB_G0276457 | 40S ribosomal protein S15a |
Drosophila melanogaster | Dmel_CG2033 | Ribosomal protein S15Aa |
Drosophila melanogaster | Dmel_CG12324 | Ribosomal protein S15Ab |
Echinococcus granulosus | EgrG_000955400 | ribosomal protein S15Aa |
Entamoeba histolytica | EHI_073600 | 40S ribosomal protein S15a, putative |
Entamoeba histolytica | EHI_167270 | 40S ribosomal protein S15a, putative |
Entamoeba histolytica | EHI_105140 | 40S ribosomal protein S15a, putative |
Echinococcus multilocularis | EmuJ_000955400 | ribosomal protein S15Aa |
Giardia lamblia | GL50803_15228 | Ribosomal protein S15A |
Homo sapiens | ENSG00000134419 | ribosomal protein S15a |
Leishmania braziliensis | LbrM.11.0990 | 40S ribosomal protein S15A, putative |
Leishmania braziliensis | LbrM.31.0190 | 40S ribosomal protein S15a |
Leishmania donovani | LdBPK_291920.1 | 40S ribosomal protein S15A, putative |
Leishmania donovani | LdBPK_111180.1 | 40S ribosomal protein S15A, putative |
Leishmania infantum | LinJ.29.1920 | 40S ribosomal protein S15A, putative |
Leishmania infantum | LinJ.11.1180 | 40S ribosomal protein S15A, putative |
Leishmania major | LmjF.29.1800 | 40S ribosomal protein S15A, putative |
Leishmania major | LmjF.11.1190 | 40S ribosomal protein S15A, putative |
Leishmania mexicana | LmxM.11.1190 | 40S ribosomal protein S15A, putative |
Leishmania mexicana | LmxM.08_29.1800 | 40S ribosomal protein S15A, putative |
Loa Loa (eye worm) | LOAG_03447 | ribosomal protein rps15a |
Mus musculus | ensembl-mmu:ENSMUSG00000008683 | ribosomal protein S15A |
Neospora caninum | NCLIV_049600 | 30S ribosomal protein S8P, related |
Oryza sativa | 4329361 | Os02g0478600 |
Oryza sativa | 4342697 | Os07g0208000 |
Plasmodium berghei | PBANKA_0414600 | 40S ribosomal protein S15A, putative |
Plasmodium falciparum | PF3D7_0316800 | 40S ribosomal protein S15A, putative |
Plasmodium knowlesi | PKNH_0825000 | 40S ribosomal protein S15A, putative |
Plasmodium vivax | PVX_095390 | 40S ribosomal protein S15Aa, putative |
Plasmodium yoelii | PY04951 | ribosomal protein S8 |
Saccharomyces cerevisiae | YLR367W | ribosomal 40S subunit protein S22B |
Saccharomyces cerevisiae | YJL190C | ribosomal 40S subunit protein S22A |
Schistosoma japonicum | Sjp_0217780 | ko:K02957 small subunit ribosomal protein S15Ae, putative |
Schistosoma mansoni | Smp_076740 | 30S ribosomal protein S8 |
Schmidtea mediterranea | mk4.000065.25 | 40S ribosomal protein S15a |
Trypanosoma brucei gambiense | Tbg972.11.6920 | 40S ribosomal protein S15A, putative |
Trypanosoma brucei gambiense | Tbg972.3.4760 | 40S ribosomal protein S15A, putative |
Trypanosoma brucei | Tb927.3.4360 | 40S ribosomal protein S15A, putative |
Trypanosoma brucei | Tb927.11.6140 | 40S ribosomal protein S15A, putative |
Trypanosoma cruzi | TcCLB.506297.330 | 40S ribosomal protein S15A, putative |
Trypanosoma cruzi | TcCLB.508041.30 | 40S ribosomal protein S15A, putative |
Trypanosoma cruzi | TcCLB.509381.20 | 40S ribosomal protein S15A, putative |
Toxoplasma gondii | TGME49_234450 | ribosomal protein RPS15A |
Theileria parva | TP02_0064 | 40S ribosomal protein S15a, putative |
Trichomonas vaginalis | TVAG_462530 | 30S ribosomal protein S8, putative |
Trichomonas vaginalis | TVAG_164700 | 30S ribosomal protein S8, putative |
Trichomonas vaginalis | TVAG_006250 | 30S ribosomal protein S8, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4000 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4000 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4000 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.4000 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F53A3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F53A3.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F53A3.3 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_234450 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.