pI: 8.223 |
Length (AA): 316 |
MW (Da): 35321 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
29 | 293 | 4cru (B) | 18 | 285 | 52.00 | 0 | 1 | 1.64791 | -2.31 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128041)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G12980 | Cell differentiation, Rcd1-like protein |
Arabidopsis thaliana | AT3G20800 | cell differentiation, Rcd1-like protein |
Babesia bovis | BBOV_III004860 | cell differentiation family protein |
Brugia malayi | Bm1_45760 | Cell differentiation protein rcd1 |
Candida albicans | CaO19.7198 | similar to S. cerevisiae CAF40 (YNL288W) Rcd1-like factor associated with the CCR4-NOT transcription factor complex |
Candida albicans | CaO19_7198 | hypothetical protein |
Caenorhabditis elegans | CELE_C26E6.3 | Protein NTL-9 |
Cryptosporidium hominis | Chro.80511 | cell differentiation protein rcd1 |
Cryptosporidium parvum | cgd8_4460 | cell differentiation protein rcd1, putative |
Dictyostelium discoideum | DDB_G0269778 | cell differentiation family, Rcd1-like protein |
Drosophila melanogaster | Dmel_CG14213 | Required for cell differentiation 1 ortholog |
Echinococcus granulosus | EgrG_000966200 | cell differentiation protein rcd1 |
Entamoeba histolytica | EHI_093570 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000966200 | cell differentiation protein rcd1 |
Homo sapiens | ENSG00000144580 | RCD1 required for cell differentiation1 homolog (S. pombe) |
Leishmania braziliensis | LbrM.20.4010 | cell differentiation protein-like protein |
Leishmania donovani | LdBPK_344180.1 | cell differentiation protein-like protein |
Leishmania infantum | LinJ.34.4180 | cell differentiation protein-like protein |
Leishmania major | LmjF.34.4550 | cell differentiation protein-like protein |
Leishmania mexicana | LmxM.33.4550 | cell differentiation protein-like protein |
Mus musculus | ENSMUSG00000026174 | rcd1 (required for cell differentiation) homolog 1 (S. pombe) |
Neospora caninum | NCLIV_027510 | hypothetical protein |
Oryza sativa | 4343622 | Os07g0565200 |
Oryza sativa | 4336974 | Os04g0613400 |
Plasmodium berghei | PBANKA_1107200 | cell differentiation protein, putative |
Plasmodium falciparum | PF3D7_0507600 | cell differentiation protein, putative |
Plasmodium knowlesi | PKNH_1026000 | cell differentiation protein, putative |
Plasmodium vivax | PVX_097940 | cell differentiation protein rcd1, putative |
Plasmodium yoelii | PY05128 | hypothetical protein |
Saccharomyces cerevisiae | YNL288W | CCR4-NOT core subunit CAF40 |
Schistosoma japonicum | Sjp_0076130 | Cell differentiation protein RCD1 homolog, putative |
Schistosoma japonicum | Sjp_0311130 | Cell differentiation protein RCD1 homolog, putative |
Schmidtea mediterranea | mk4.001835.02 | Cell differentiation protein RCD1 homolog |
Trypanosoma brucei gambiense | Tbg972.4.140 | cell differentiation protein, putative |
Trypanosoma brucei | Tb927.4.410 | CAF 40 |
Trypanosoma congolense | TcIL3000_4_90 | cell differentiation protein, putative |
Trypanosoma cruzi | TcCLB.510689.50 | cell differentiation protein, putative |
Trypanosoma cruzi | TcCLB.507873.20 | cell differentiation protein, putative |
Toxoplasma gondii | TGME49_258980 | hypothetical protein |
Theileria parva | TP02_0463 | hypothetical protein |
Trichomonas vaginalis | TVAG_149000 | protein CAF40, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.410 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.410 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.4.410 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C26E6.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1107200 | Plasmodium berghei | Essential | plasmo |
TGME49_258980 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.