Detailed view for PF3D7_1146500

Basic information

TDR Targets ID: 1941
Plasmodium falciparum, leucine-rich repeat protein
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.8996 | Length (AA): 317 | MW (Da): 37423 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 308 1o6v (A) 75 356 20.00 0 1 1.17 -0.81
202 305 1a9n (A) 52 154 20.00 0.000065 0.93 0.69 -1.12
1 314 1o6v (A) 70 364 19.00 0.00000000005 1 1.15914 0.35
7 76 2fxm (B) 885 961 36.00 0.23 0.02 0.55692 -1.11
220 308 2wfh (A) 760 842 13.00 0.0016 0.19 0.292357 0.41
2 321 1o6v (A) 106 413 18.00 0.0000000002 0.81 1.12979 0.45
7 81 2fxm (B) 885 961 33.00 0.18 0.05 0.679519 -1.68
41 320 4aw4 (A) 55 256 18.00 0.0000077 1 0.594565 1.35
136 233 1ds9 (A) 53 154 35.00 0.3 0.58 0.575948 0.5
241 310 1a9n (A) 88 154 21.00 0.79 1 0.523391 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Ring. Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst, Female Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_132879)

Species Accession Gene Product
Echinococcus granulosus EgrG_000378200   leucine rich repeat containing protein 23
Echinococcus multilocularis EmuJ_000378200   leucine rich repeat containing protein 23
Homo sapiens ENSG00000010626   leucine rich repeat containing 23
Mus musculus ENSMUSG00000030125   leucine rich repeat containing 23
Neospora caninum NCLIV_066980   B7 isoform, related
Plasmodium falciparum PF3D7_1146500   leucine-rich repeat protein
Plasmodium knowlesi PKNH_0944300   leucine-rich repeat protein
Plasmodium vivax PVX_092920   leucine-rich repeat protein
Plasmodium yoelii PY07650   hypothetical protein
Schistosoma japonicum Sjp_0314050   expressed protein
Schistosoma japonicum Sjp_0096760   Leucine-rich repeat-containing protein 23, putative
Schistosoma mansoni Smp_141280   calpain 4 6 7 invertebrate
Schmidtea mediterranea mk4.000503.04  
Schmidtea mediterranea mk4.000246.10  
Schmidtea mediterranea mk4.003460.00   Putative calpain 4, 6, 7, invertebrate
Schmidtea mediterranea mk4.000503.03  
Toxoplasma gondii TGME49_251940   leucine rich repeat-containing protein
Trichomonas vaginalis TVAG_052080   toll, putative
Trichomonas vaginalis TVAG_376110   leucine-rich repeat-containing protein 17, lrc17, putative

Essentiality

PF3D7_1146500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_251940 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1146500 (Plasmodium falciparum), leucine-rich repeat protein
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