Detailed view for Tb927.4.1110

Basic information

TDR Targets ID: 19560
Trypanosoma brucei, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6938 | Length (AA): 459 | MW (Da): 50910 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127556)

Species Accession Gene Product
Candida albicans CaO19.7016   vacuolar polyphosphatase
Candida albicans CaO19_7016   hypothetical protein
Caenorhabditis elegans CELE_ZK856.5   Protein ZK856.5
Caenorhabditis elegans CELE_ZK856.18   Protein ZK856.18
Dictyostelium discoideum DDB_G0268330   hypothetical protein
Dictyostelium discoideum DDB_G0282265   metallophosphoesterase domain-containing protein
Drosophila melanogaster Dmel_CG32052   CG32052 gene product from transcript CG32052-RC
Echinococcus granulosus EgrG_001109500   acid sphingomyelinase phosphodiesterase 3b
Entamoeba histolytica EHI_172510   acid sphingomyelinase-like phosphodiesterase 3a precursor, putative
Entamoeba histolytica EHI_125660   acid sphingomyelinase-like phosphodiesterase, putative
Entamoeba histolytica EHI_100080   acid sphingomyelinase-like phosphodiesterase, putative
Echinococcus multilocularis EmuJ_001109500   acid sphingomyelinase phosphodiesterase 3b
Giardia lamblia GL50803_16737   Acid sphingomyelinase-like phosphodiesterase 3b precursor
Giardia lamblia GL50803_8360   Acid sphingomyelinase-like phosphodiesterase 3b precursor
Homo sapiens ENSG00000172594   sphingomyelin phosphodiesterase, acid-like 3A
Homo sapiens ENSG00000130768   sphingomyelin phosphodiesterase, acid-like 3B
Leishmania braziliensis LbrM.20.3210   hypothetical protein, conserved
Leishmania donovani LdBPK_343410.1   hypothetical protein, conserved
Leishmania infantum LinJ.34.3410   hypothetical protein, conserved
Leishmania infantum LinJ.35.0640   beta-fructofuranosidase-like protein
Leishmania major LmjF.34.3630   hypothetical protein, conserved
Leishmania mexicana LmxM.33.3630   hypothetical protein, conserved
Mus musculus ENSMUSG00000019872   sphingomyelin phosphodiesterase, acid-like 3A
Mus musculus ENSMUSG00000028885   sphingomyelin phosphodiesterase, acid-like 3B
Saccharomyces cerevisiae YDR452W   Ppn1p
Schistosoma japonicum Sjp_0004960   ko:K01128 SMPDL3B, LOC769013; sphingomyelin phosphodiesterase, acid-like 3B [EC:3.1.4.-], putative
Schistosoma mansoni Smp_133330   hypothetical protein
Schmidtea mediterranea mk4.004549.04  
Schmidtea mediterranea mk4.003734.01  
Schmidtea mediterranea mk4.006060.00  
Schmidtea mediterranea mk4.011233.00  
Schmidtea mediterranea mk4.002408.04  
Schmidtea mediterranea mk4.003734.02  
Schmidtea mediterranea mk4.043629.00  
Schmidtea mediterranea mk4.007239.04  
Schmidtea mediterranea mk4.000520.08  
Trypanosoma brucei gambiense Tbg972.4.940   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.1110   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_0_06660   Calcineurin-like phosphoesterase, putative
Trypanosoma cruzi TcCLB.507251.10   hypothetical protein, conserved
Trichomonas vaginalis TVAG_576590   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_342080   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_062580   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_271580   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_289530   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_222460   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_352120   sphingomyelin phosphodiesterase, putative
Trichomonas vaginalis TVAG_020780   sphingomyelin phosphodiesterase, putative

Essentiality

Tb927.4.1110 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1110 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.1110 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.1110 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.1110 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.4.1110 (Trypanosoma brucei), hypothetical protein, conserved
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