pI: 6.3702 |
Length (AA): 488 |
MW (Da): 52891 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 72 | 4kdw (A) | 6 | 72 | 21.00 | 0 | 0.2 | 0.331446 | -0.1 |
52 | 166 | 4qhz (A) | 126 | 257 | 28.00 | 0.1 | 0.06 | 0.226356 | 1.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127000)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G38250 | transmembrane amino acid transporter family protein |
Arabidopsis thaliana | AT2G42005 | transmembrane amino acid transporter family protein |
Arabidopsis thaliana | AT5G65990 | transmembrane amino acid transporter family protein |
Brugia malayi | Bm1_41420 | protein T27A1.5 |
Candida albicans | CaO19.6984 | potential second version of transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-l |
Candida albicans | CaO19.1142 | similar to transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-like organelles |
Candida albicans | CaO19.8735 | similar to transmembrane amino acid transporter that controls efflux of large neutral amino acids in vacuolar-like organelles |
Caenorhabditis elegans | CELE_T27A1.5 | Protein T27A1.5, isoform B |
Caenorhabditis elegans | CELE_Y43F4B.7 | Protein Y43F4B.7 |
Cryptosporidium hominis | Chro.70533 | hypothetical protein |
Cryptosporidium parvum | cgd7_4800 | ABC transporter, amino acid transporter 12 transmembrane spanning subunit |
Dictyostelium discoideum | DDB_G0293074 | hypothetical protein |
Drosophila melanogaster | Dmel_CG4991 | CG4991 gene product from transcript CG4991-RF |
Drosophila melanogaster | Dmel_CG43693 | CG43693 gene product from transcript CG43693-RD |
Drosophila melanogaster | Dmel_CG13384 | CG13384 gene product from transcript CG13384-RD |
Echinococcus granulosus | EgrG_000983500 | Proton coupled amino acid transporter 1 |
Echinococcus multilocularis | EmuJ_000983500 | Proton coupled amino acid transporter 1 |
Homo sapiens | ENSG00000123643 | solute carrier family 36 (proton/amino acid symporter), member 1 |
Homo sapiens | ENSG00000180773 | solute carrier family 36 (proton/amino acid symporter), member 4 |
Homo sapiens | ENSG00000186335 | solute carrier family 36 (proton/amino acid symporter), member 2 |
Leishmania braziliensis | LbrM.10.0840 | amino acid transporter, putative |
Leishmania braziliensis | LbrM.35.1500 | amino acid transporter |
Leishmania donovani | LdBPK_100760.1 | amino acid permease 24 |
Leishmania donovani | LdBPK_100770.1 | amino acid permease 24 |
Leishmania infantum | LinJ.10.0760 | amino acid transporter, putative |
Leishmania infantum | LinJ.10.0770 | amino acid transporter, putative |
Leishmania major | LmjF.10.0720 | amino acid transporter, putative |
Leishmania major | LmjF.10.0715 | amino acid transporter, putative |
Leishmania major | LmjF.10.0710 | amino acid transporter, putative |
Leishmania mexicana | LmxM.10.0720 | amino acid transporter, putative |
Loa Loa (eye worm) | LOAG_05400 | hypothetical protein |
Mus musculus | ENSMUSG00000020264 | solute carrier family 36 (proton/amino acid symporter), member 2 |
Mus musculus | ENSMUSG00000020261 | solute carrier family 36 (proton/amino acid symporter), member 1 |
Mus musculus | ENSMUSG00000043885 | solute carrier family 36 (proton/amino acid symporter), member 4 |
Neospora caninum | NCLIV_045690 | hypothetical protein |
Neospora caninum | NCLIV_045730 | hypothetical protein, conserved |
Neospora caninum | NCLIV_045700 | transmembrane amino acid transporter domain- containing protein, putative |
Oryza sativa | 4342775 | Os07g0231400 |
Oryza sativa | 4330274 | Os02g0670900 |
Oryza sativa | 4334572 | Os03g0817200 |
Oryza sativa | 4336684 | Os04g0565500 |
Onchocerca volvulus | OVOC8753 |
|
Saccharomyces cerevisiae | YKL146W | Avt3p |
Saccharomyces cerevisiae | YNL101W | Avt4p |
Schistosoma japonicum | Sjp_0310360 | Proton-coupled amino acid transporter 4, putative |
Schistosoma japonicum | Sjp_0213090 | Proton-coupled amino acid transporter 4, putative |
Schistosoma mansoni | Smp_029360 | amino acid transporter |
Schmidtea mediterranea | mk4.009229.00 | Amino acid transporter, putative |
Schmidtea mediterranea | mk4.021624.00 | Amino acid transporter, putative |
Schmidtea mediterranea | mk4.028704.00 | Amino acid transporter, putative |
Trypanosoma brucei gambiense | Tbg972.10.7020 | amino acid tansporter, putative |
Trypanosoma brucei gambiense | Tbg972.8.5420 | amino acid transporter, putative |
Trypanosoma brucei | Tb927.10.5780 | amino acid tansporter, putative |
Trypanosoma brucei | Tb927.8.5450 | amino acid permease 24 |
Trypanosoma congolense | TcIL3000_8_5260 | amino acid permease 24, putative |
Trypanosoma congolense | TcIL3000_10_4830 | amino acid tansporter, putative |
Trypanosoma cruzi | TcCLB.504229.110 | amino acid permease 24, putative |
Trypanosoma cruzi | TcCLB.509733.160 | amino acid tansporter, putative |
Trypanosoma cruzi | TcCLB.504069.120 | amino acid permease 24, putative |
Toxoplasma gondii | TGME49_227570 | transmembrane amino acid transporter protein |
Toxoplasma gondii | TGME49_227580 | transmembrane amino acid transporter protein |
Toxoplasma gondii | TGME49_227430 | transmembrane amino acid transporter protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5450 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5450 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5450 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.5450 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.5780 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5780 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5780 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.5780 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_227570 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_227430 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_227580 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.