Detailed view for Tb927.8.7600

Basic information

TDR Targets ID: 19800
Trypanosoma brucei, amino acid transporter, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0784 | Length (AA): 467 | MW (Da): 49639 | Paralog Number: 18

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 11

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01490   Transmembrane amino acid transporter protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0005275   amine transmembrane transporter activity  
GO:0016020   membrane  
GO:0006865   amino acid transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic. Siegel TN
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126804)

Species Accession Gene Product
Arabidopsis thaliana AT1G80510   amino acid transporter ANT1-like protein
Arabidopsis thaliana AT2G40420   transmembrane amino acid transporter-like protein
Arabidopsis thaliana AT3G56200   putative amino acid transporter
Cryptosporidium hominis Chro.80431   transmembrane transporter
Cryptosporidium parvum cgd8_3740   Yer119cp like amino acid transporter, 11 transmembrane domain
Entamoeba histolytica EHI_115320   amino acid transporter, putative
Entamoeba histolytica EHI_182750   amino acid transporter, putative
Giardia lamblia GL50803_17214   Amino acid transporter system N2, putative
Giardia lamblia GL50803_14168   Amino acid transporter system N2, putative
Homo sapiens ENSG00000111371   solute carrier family 38, member 1
Leishmania braziliensis LbrM.35.0510   amino acid permease-like protein
Leishmania braziliensis LbrM.22.0220   amino acid permease, putative
Leishmania braziliensis LbrM.31.0740   amino acid transporter aATP11, putative
Leishmania braziliensis LbrM.31.0730   amino acid transporter aATP11, putative
Leishmania donovani LdBPK_360450.1   amino acid permease-like protein
Leishmania donovani LdBPK_310600.1   amino acid transporter aATP11, putative
Leishmania donovani LdBPK_220100.1   amino acid permease, putative
Leishmania donovani LdBPK_310590.1   amino acid transporter aATP11, putative
Leishmania infantum LinJ.31.0590   amino acid transporter aATP11, putative
Leishmania infantum LinJ.36.0450   amino acid permease-like protein
Leishmania infantum LinJ.22.0100   amino acid permease, putative
Leishmania infantum LinJ.31.0600   amino acid transporter aATP11, putative
Leishmania major LmjF.22.0230   amino acid permease, putative
Leishmania major LmjF.36.0420   amino acid permease-like protein
Leishmania major LmjF.31.0570   amino acid transporter aATP11, putative
Leishmania mexicana LmxM.30.0570   amino acid transporter aATP11, putative
Leishmania mexicana LmxM.22.0230   amino acid permease, putative
Leishmania mexicana LmxM.36.0420   amino acid permease-like protein
Leishmania mexicana LmxM.30.0571   amino acid transporter aATP11, putative
Mus musculus ENSMUSG00000023169   solute carrier family 38, member 1
Neospora caninum NCLIV_046770   transmembrane amino acid transporter, putative
Oryza sativa 4327515   Os01g0825800
Oryza sativa 4341591   Os06g0633800
Oryza sativa 4341650   Os06g0644700
Oryza sativa 4328577   Os02g0191300
Plasmodium berghei PBANKA_1128300   amino acid transporter, putative
Plasmodium yoelii PY04168   Transmembrane amino acid transporter protein, putative
Trypanosoma brucei gambiense Tbg972.4.4130   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.4.4120   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.4.5020   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.7920   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.7910   amino acid transporter 1, putative
Trypanosoma brucei gambiense Tbg972.4.4890   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.7990   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.4.5000   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.8630   amino acid transporter AATP5
Trypanosoma brucei gambiense Tbg972.8.8640   amino acid transporter, putative
Trypanosoma brucei gambiense Tbg972.8.7900   amino acid transporter 1, putative
Trypanosoma brucei gambiense Tbg972.8.7890   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7670   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7740   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8300   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7610   amino acid transporter 1, putative
Trypanosoma brucei Tb927.4.3990   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7600   amino acid transporter, putative
Trypanosoma brucei Tb927.8.8290   amino acid transporter AATP5
Trypanosoma brucei Tb927.8.7620   amino acid transporter 1, putative
Trypanosoma brucei Tb927.4.4870   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7630   amino acid transporter 1, putative
Trypanosoma brucei Tb927.4.4830   amino acid transporter, putative
Trypanosoma brucei Tb927.4.4850   amino acid transporter, putative
Trypanosoma brucei Tb927.4.4000   amino acid transporter, putative
Trypanosoma brucei Tb927.4.4010   amino acid transporter, putative
Trypanosoma brucei Tb11.v5.0541   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7640   amino acid transporter 1, putative
Trypanosoma brucei Tb927.4.4020   amino acid transporter, putative
Trypanosoma brucei Tb927.4.4730   amino acid transporter, putative
Trypanosoma brucei Tb927.8.7650   amino acid transporter, putative
Trypanosoma congolense TcIL3000_0_13970   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_13960   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_52900   amino acid transporter, putative
Trypanosoma congolense TcIL3000_0_02660   amino acid transporter, putative
Trypanosoma congolense TcIL3000_10_13960   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_48390   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_12050   transmembrane amino acid transporter protein, putative
Trypanosoma congolense TcIL3000_0_48420   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_13920   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_13980   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_48380   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_13930   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_13950   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_48430   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_10_13950   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_10_13970   amino acid transporter 10, putative
Trypanosoma congolense TcIL3000_0_48400   amino acid transporter 10, putative
Trypanosoma cruzi TcCLB.507659.20   amino acid transporter, putative
Trypanosoma cruzi TcCLB.507585.10   amino acid transporter, putative
Trichomonas vaginalis TVAG_405780   amino acid transporter, putative
Trichomonas vaginalis TVAG_295310   amino acid transporter, putative
Trichomonas vaginalis TVAG_129890   amino acid transporter, putative
Trichomonas vaginalis TVAG_284500   amino acid transporter, putative
Trichomonas vaginalis TVAG_019720   amino acid transporter, putative
Trichomonas vaginalis TVAG_364530   amino acid transporter, putative
Trichomonas vaginalis TVAG_365480   amino acid transporter, putative
Trichomonas vaginalis TVAG_193280   amino acid transporter, putative
Trichomonas vaginalis TVAG_473890   amino acid transporter, putative
Trichomonas vaginalis TVAG_119480   amino acid transporter, putative
Trichomonas vaginalis TVAG_372140   amino acid transporter, putative
Trichomonas vaginalis TVAG_252610   conserved hypothetical protein
Trichomonas vaginalis TVAG_495480   amino acid transporter, putative
Trichomonas vaginalis TVAG_124980   amino acid transporter, putative
Trichomonas vaginalis TVAG_435890   amino acid transporter, putative
Trichomonas vaginalis TVAG_238910   amino acid transporter, putative
Trichomonas vaginalis TVAG_394440   amino acid transporter, putative
Trichomonas vaginalis TVAG_210570   amino acid transporter, putative
Trichomonas vaginalis TVAG_257020   amino acid transporter, putative
Trichomonas vaginalis TVAG_185720   amino acid transporter, putative
Trichomonas vaginalis TVAG_456720   hypothetical protein
Trichomonas vaginalis TVAG_129880   amino acid transporter, putative
Trichomonas vaginalis TVAG_091940   amino acid transporter, putative
Trichomonas vaginalis TVAG_124970   amino acid transporter, putative
Trichomonas vaginalis TVAG_303350   amino acid transporter, putative
Trichomonas vaginalis TVAG_456710   conserved hypothetical protein
Trichomonas vaginalis TVAG_382600   amino acid transporter, putative
Trichomonas vaginalis TVAG_236650   amino acid transporter, putative
Trichomonas vaginalis TVAG_125700   amino acid transporter, putative
Trichomonas vaginalis TVAG_251530   conserved hypothetical protein
Trichomonas vaginalis TVAG_445140   amino acid transporter, putative
Trichomonas vaginalis TVAG_151340   amino acid transporter, putative
Trichomonas vaginalis TVAG_188740   amino acid transporter, putative
Trichomonas vaginalis TVAG_139670   amino acid transporter, putative

Essentiality

Tb927.8.7600 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.8300 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.8300 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.8300 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.8.8300 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.3990 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.3990 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.3990 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.3990 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7740 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7740 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7740 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7740 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.8290 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.8290 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.8290 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.8290 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7600 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7600 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7600 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7600 this record Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.4020 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4020 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.4020 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.4870 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4870 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4870 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.4870 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.4.4730 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4730 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4730 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.4730 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7610 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7610 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7610 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7610 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tb927.8.7600 (Trypanosoma brucei), amino acid transporter, putative
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