pI: 12.1283 |
Length (AA): 374 |
MW (Da): 41856 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127050)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G09630 | 60S ribosomal protein L4-1 |
Arabidopsis thaliana | AT5G02870 | 60S ribosomal protein L4-2 |
Babesia bovis | BBOV_II006110 | ribosomal protein RPL4A |
Brugia malayi | Bm1_14285 | 60S ribosomal protein L4 |
Candida albicans | CaO19.7217 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL4A (YBR031W) and RPL4B (YDR012W) large subunit protein L4 |
Caenorhabditis elegans | CELE_B0041.4 | Protein RPL-4 |
Cryptosporidium hominis | Chro.60371 | 60S ribosomal protein-like |
Cryptosporidium hominis | Chro.60369 | hypothetical protein |
Cryptosporidium parvum | cgd6_3190 | 60S ribosomal protein-like, putative |
Dictyostelium discoideum | DDB_G0277803 | 60S ribosomal protein L4 |
Drosophila melanogaster | Dmel_CG5502 | Ribosomal protein L4 |
Echinococcus granulosus | EgrG_000860300 | ribosomal protein l4 |
Entamoeba histolytica | EHI_064710 | 60S ribosomal protein L4, putative |
Entamoeba histolytica | EHI_194270 | 60S ribosomal protein L4, putative |
Entamoeba histolytica | EHI_035440 | 60S ribosomal protein L4, putative |
Entamoeba histolytica | EHI_000510 | 60S ribosomal protein L4, putative |
Echinococcus multilocularis | EmuJ_000860300 | ribosomal protein l4 |
Giardia lamblia | GL50803_17547 | Ribosomal protein L4 |
Homo sapiens | 6124 | ribosomal protein L4 |
Leishmania braziliensis | LbrM.29.1180 | ribosomal protein L1a, putative |
Leishmania braziliensis | LbrM.29.1150 | ribosomal protein L1a, putative |
Leishmania donovani | LdBPK_291160.1 | ribosomal protein L1a, putative |
Leishmania infantum | LinJ.29.1170 | ribosomal protein L1a, putative |
Leishmania infantum | LinJ.29.1160 | ribosomal protein L1a, putative |
Leishmania infantum | LinJ.29.1180 | ribosomal protein L1a, putative |
Leishmania major | LmjF.29.1070 | ribosomal protein L1a, putative |
Leishmania major | LmjF.29.1080 | ribosomal protein L1a, putative |
Leishmania major | LmjF.29.1090 | ribosomal protein L1a, putative |
Leishmania mexicana | LmxM.08_29.1090 | ribosomal protein L1a, putative |
Leishmania mexicana | LmxM.08_29.1070 | ribosomal protein L1a, putative |
Loa Loa (eye worm) | LOAG_00227 | 60S ribosomal protein L4 |
Mus musculus | ENSMUSG00000032399 | ribosomal protein L4 |
Neospora caninum | NCLIV_053580 | 50S ribosomal protein L4P, related |
Oryza sativa | 9272589 | Os03g0796501 |
Oryza sativa | 4342563 | Os07g0180900 |
Plasmodium berghei | PBANKA_1106700 | 60S ribosomal protein L4, putative |
Plasmodium falciparum | PF3D7_0507100 | 60S ribosomal protein L4 |
Plasmodium knowlesi | PKNH_1026500 | 60S ribosomal protein L4, putative |
Plasmodium vivax | PVX_097915 | 60S ribosomal protein L4, putative |
Plasmodium yoelii | PY06225 | ribosomal protein L4/L1 family, putative |
Saccharomyces cerevisiae | YDR012W | ribosomal 60S subunit protein L4B |
Saccharomyces cerevisiae | YBR031W | ribosomal 60S subunit protein L4A |
Schistosoma japonicum | Sjp_0062490 | ko:K02930 large subunit ribosomal protein L4e, putative |
Schistosoma mansoni | Smp_153790 | 60S ribosomal protein L4 |
Schmidtea mediterranea | mk4.000687.05 | Putative 60s ribosomal protein L4 |
Schmidtea mediterranea | mk4.000363.05 | Putative 60s ribosomal protein L4 |
Trypanosoma brucei gambiense | Tbg972.3.5660 | 60S ribosomal protein L4 |
Trypanosoma brucei gambiense | Tbg972.3.5650 | 60S ribosomal protein L4 |
Trypanosoma brucei | Tb927.3.5050 | 60S ribosomal protein L4 |
Trypanosoma cruzi | TcCLB.509995.10 | 60S ribosomal protein L4, putative |
Trypanosoma cruzi | TcCLB.504121.30 | 60S ribosomal protein L4, putative |
Toxoplasma gondii | TGME49_309120 | ribosomal protein RPL4 |
Theileria parva | TP02_0568 | 60S ribosomal protein L4/L1, putative |
Trichomonas vaginalis | TVAG_164550 | 60S ribosomal protein L4, putative |
Trichomonas vaginalis | TVAG_128790 | 60S ribosomal protein L4, putative |
Trichomonas vaginalis | TVAG_476810 | 60S ribosomal protein L4, putative |
Trichomonas vaginalis | TVAG_189110 | 60S ribosomal protein L4, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.5050 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.5050 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.5050 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.3.5050 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_B0041.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0041.4 | Caenorhabditis elegans | sterile | wormbase |
TGME49_309120 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.