pI: 6.4874 |
Length (AA): 1362 |
MW (Da): 152892 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129394)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_23330 | TPR Domain containing protein |
Caenorhabditis elegans | CELE_ZK328.7 | Protein ZK328.7, isoform B |
Echinococcus granulosus | EgrG_000952700 | tetratricopeptide repeat protein 21b |
Echinococcus multilocularis | EmuJ_000952700 | titin |
Homo sapiens | ENSG00000123607 | tetratricopeptide repeat domain 21B |
Homo sapiens | ENSG00000168026 | tetratricopeptide repeat domain 21A |
Leishmania braziliensis | LbrM.04.0600 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_040540.1 | TPR repeat/Tetratricopeptide repeat, putative |
Leishmania infantum | LinJ.04.0540 | hypothetical protein, conserved |
Leishmania major | LmjF.04.0550 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.04.0550 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04046 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04047 | hypothetical protein |
Mus musculus | ENSMUSG00000032514 | tetratricopeptide repeat domain 21A |
Mus musculus | ENSMUSG00000034848 | tetratricopeptide repeat domain 21B |
Neospora caninum | NCLIV_017520 | TPR Domain containing protein, putative |
Onchocerca volvulus | OVOC9174 | Tetratricopeptide repeat protein 21 homolog |
Schistosoma japonicum | Sjp_0118160 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma japonicum | Sjp_0089470 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma japonicum | Sjp_0089460 | Tetratricopeptide repeat protein 21B, putative |
Schistosoma mansoni | Smp_179920 | hypothetical protein |
Schmidtea mediterranea | mk4.004137.06 | |
Schmidtea mediterranea | mk4.004137.05 | Tetratricopeptide repeat protein 21 homolog |
Schmidtea mediterranea | mk4.004137.02 | |
Trypanosoma brucei gambiense | Tbg972.9.4220 | tetratricopeptide repeat protein, predicted |
Trypanosoma brucei | Tb927.9.7720 | predicted tetratricopeptide repeat protein |
Trypanosoma congolense | TcIL3000_9_2650 | predicted tetratricopeptide repeat protein |
Trypanosoma cruzi | TcCLB.504033.180 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508199.90 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_242360 | tetratricopeptide repeat-containing protein |
Toxoplasma gondii | TGME49_242350 | tetratricopeptide repeat-containing protein |
Trichomonas vaginalis | TVAG_491240 | TPR repeat-containing protein ZK328.7, putative |
Trichomonas vaginalis | TVAG_006830 | TPR repeat-containing protein ZK328.7, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.5670 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.5670 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.5670 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.5670 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_242350 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_242360 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.