Detailed view for PF3D7_1302800

Basic information

TDR Targets ID: 2009
Plasmodium falciparum, 40S ribosomal protein S7, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.4601 | Length (AA): 194 | MW (Da): 22481 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01251   Ribosomal protein S7e

Gene Ontology

Mouse over links to read term descriptions.
GO:0022627   cytosolic small ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 189 4kzy (H) 5 190 43.00 0 1 1.40751 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, late ring, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile merozoite, early schizont, early trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, late schizont. PlasmoDB
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127368)

Species Accession Gene Product
Arabidopsis thaliana AT1G48830   40S ribosomal protein S7-1
Arabidopsis thaliana AT5G16130   40S ribosomal protein S7-3
Arabidopsis thaliana AT3G02560   40S ribosomal protein S7-2
Babesia bovis BBOV_III009350   ribosomal protein S7e family protein
Brugia malayi Bm1_09900   40S ribosomal protein S7
Candida albicans CaO19.1700   likely cytosolic ribosomal protein similar to S. cerevisiae RPS7A (YOR096W) and RPS7B (YNL096C) small subunit protein S7
Candida albicans CaO19.9267   likely cytosolic ribosomal protein similar to S. cerevisiae RPS7A (YOR096W) and RPS7B (YNL096C) small subunit protein S7
Caenorhabditis elegans CELE_ZC434.2   Protein RPS-7
Cryptosporidium hominis Chro.50070   40S ribosomal protein S7
Cryptosporidium parvum cgd5_3040   40S ribosomal protein S7
Dictyostelium discoideum DDB_G0289025   40S ribosomal protein S7
Drosophila melanogaster Dmel_CG1883   Ribosomal protein S7
Echinococcus granulosus EgrG_000844100   expressed protein
Entamoeba histolytica EHI_140540   40S ribosomal protein S7, putative
Entamoeba histolytica EHI_067530   40S ribosomal protein S7, putative
Echinococcus multilocularis EmuJ_000844100   expressed protein
Giardia lamblia GL50803_14329   Ribosomal protein S7
Homo sapiens ENSG00000171863   ribosomal protein S7
Leishmania braziliensis LbrM.01.0460   ribosomal protein S7, putative
Leishmania braziliensis LbrM.01.0470   ribosomal protein S7, putative
Leishmania donovani LdBPK_010440.1   ribosomal protein S7, putative
Leishmania infantum LinJ.01.0440   ribosomal protein S7, putative
Leishmania infantum LinJ.01.0430   ribosomal protein S7, putative
Leishmania major LmjF.01.0410   ribosomal protein S7, putative
Leishmania major LmjF.01.0420   ribosomal protein S7, putative
Leishmania mexicana LmxM.01.0410  
Loa Loa (eye worm) LOAG_13113   40S ribosomal protein S7
Mus musculus 102638448   40S ribosomal protein S7-like
Mus musculus ENSMUSG00000061477   ribosomal protein S7
Neospora caninum NCLIV_015880   hypothetical protein
Oryza sativa 4338485   Os05g0346300
Oryza sativa 4332545   Os03g0297100
Plasmodium berghei PBANKA_1401300   40S ribosomal protein S7, putative
Plasmodium falciparum PF3D7_1302800   40S ribosomal protein S7, putative
Plasmodium knowlesi PKNH_1403000   40S ribosomal protein S7, putative
Plasmodium vivax PVX_121980   40S ribosomal protein S7, putative
Plasmodium yoelii PY03900   Ribosomal protein S7e
Saccharomyces cerevisiae YNL096C   ribosomal 40S subunit protein S7B
Saccharomyces cerevisiae YOR096W   ribosomal 40S subunit protein S7A
Schistosoma japonicum Sjp_0043930   ko:K02993 small subunit ribosomal protein S7e, putative
Schistosoma mansoni Smp_021140   ribosomal protein S7
Schmidtea mediterranea mk4.004251.01   40S ribosomal protein S7
Schmidtea mediterranea mk4.006585.01   40S ribosomal protein S7
Trypanosoma brucei gambiense Tbg972.9.2080   ribosomal protein S7, putative
Trypanosoma brucei Tb927.9.3990   ribosomal protein S7, putative
Trypanosoma brucei Tb927.9.3920   ribosomal protein S7, putative
Trypanosoma congolense TcIL3000_0_19490   ribosomal protein S7, putative
Trypanosoma congolense TcIL3000_9_1270   ribosomal protein S7, putative
Trypanosoma cruzi TcCLB.506593.30   ribosomal protein S7, putative
Trypanosoma cruzi TcCLB.506593.19   ribosomal protein S7, putative
Trypanosoma cruzi TcCLB.506829.39   ribosomal protein S7, putative
Toxoplasma gondii TGME49_239100   ribosomal protein RPS7
Theileria parva TP04_0844   40S ribosomal protein S7, putative
Trichomonas vaginalis TVAG_143030   40S ribosomal protein S7, putative
Trichomonas vaginalis TVAG_198680   40S ribosomal protein S7, putative
Trichomonas vaginalis TVAG_375490   40S ribosomal protein S7, putative
Trichomonas vaginalis TVAG_199100   40S ribosomal protein S7, putative

Essentiality

PF3D7_1302800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.160.2490 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.160.2490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.2490 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZC434.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZC434.2 Caenorhabditis elegans larval arrest wormbase
CELE_ZC434.2 Caenorhabditis elegans larval lethal wormbase
CELE_ZC434.2 Caenorhabditis elegans sterile wormbase
CELE_ZC434.2 Caenorhabditis elegans terminal arrest variable wormbase
PBANKA_1401300 Plasmodium berghei Essential plasmo
TGME49_239100 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1302800 (Plasmodium falciparum), 40S ribosomal protein S7, putative
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