pI: 7.0609 |
Length (AA): 222 |
MW (Da): 26110 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 220 | 1sui (A) | 46 | 247 | 13.00 | 0 | 1 | 0.8 | -0.98 |
3 | 222 | 2f8l (A) | 71 | 294 | 16.00 | 0 | 0.99 | 1.23 | -1.56 |
3 | 219 | 2b3t (A) | 66 | 276 | 18.00 | 0 | 0.83 | 1.26 | -1.03 |
12 | 218 | 2b3t (A) | 76 | 275 | 20.00 | 0 | 1 | 1.19103 | -0.34 |
23 | 217 | 3q87 (B) | 2 | 160 | 40.00 | 0.0000000000055 | 1 | 1.15478 | -0.04 |
52 | 152 | 1dl5 (A) | 79 | 170 | 26.00 | 0.93 | 0.8 | 0.741355 | -0.44 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late trophozoite, Female Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs, late schizont, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Sporozoite. | Zanghi G |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_127713)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G13440 | S-adenosyl-L-methionine-dependent methyltransferase-like protein |
Babesia bovis | BBOV_II004490 | conserved hypothetical protein |
Brugia malayi | Bm1_54730 | methylase family protein |
Candida albicans | CaO19.331 | protein methylation |
Candida albicans | CaO19.7963 | protein methylation |
Caenorhabditis elegans | CELE_C33C12.9 | Protein C33C12.9 |
Cryptosporidium hominis | Chro.40428 | hypothetical protein |
Cryptosporidium parvum | cgd4_3740 | Ydr140wp-like HemK family methylase. archaeal-like. RNA methylase |
Dictyostelium discoideum | DDB_G0292048 | hypothetical protein |
Drosophila melanogaster | Dmel_CG9960 | CG9960 gene product from transcript CG9960-RA |
Echinococcus granulosus | EgrG_001192400 | hemK methyltransferase family |
Entamoeba histolytica | EHI_121470 | DNA methyltransferase, putative |
Echinococcus multilocularis | EmuJ_001192400 | hemK methyltransferase family |
Giardia lamblia | GL50803_1903 | DNA methyltransferase |
Homo sapiens | 29104 | N-6 adenine-specific DNA methyltransferase 1 (putative) |
Leishmania braziliensis | LbrM.32.2300 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_322220.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.32.2220 | hypothetical protein, conserved |
Leishmania major | LmjF.32.2090 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.31.2090 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02109 | methylase |
Mus musculus | ENSMUSG00000044442 | N-6 adenine-specific DNA methyltransferase 1 (putative) |
Oryza sativa | 4334624 | Os03g0824200 |
Onchocerca volvulus | OVOC10219 | HemK methyltransferase family member 2 homolog |
Plasmodium berghei | PBANKA_1401600 | methyltransferase-like protein, putative |
Plasmodium falciparum | PF3D7_1303100 | methyltransferase-like protein, putative |
Plasmodium knowlesi | PKNH_1403300 | methyltransferase-like protein, putative |
Plasmodium vivax | PVX_121995 | Putative N6-DNA-methyltransferase, putative |
Plasmodium yoelii | PY03902 | hypothetical protein |
Saccharomyces cerevisiae | YDR140W | Mtq2p |
Schistosoma japonicum | Sjp_0016240 | ko:K00571 site-specific DNA-methyltransferase (adenine-specific) [EC2.1.1.72], putative |
Schistosoma mansoni | Smp_024800 | n6-DNA-methyltransferase |
Schmidtea mediterranea | mk4.001089.10 | HemK methyltransferase family member 2 |
Trypanosoma brucei gambiense | Tbg972.11.17170 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.15290 | eRF1 methyltransferase catalytic subunit, putative |
Trypanosoma congolense | TcIL3000.11.15430 | eRF1 methyltransferase catalytic subunit, putative |
Trypanosoma cruzi | TcCLB.511711.30 | eRF1 methyltransferase catalytic subunit, putative |
Trypanosoma cruzi | TcCLB.506425.120 | eRF1 methyltransferase catalytic subunit, putative |
Toxoplasma gondii | TGME49_244240 | hypothetical protein |
Theileria parva | TP04_0566 | DNA-methyltransferase, putative |
Trichomonas vaginalis | TVAG_102430 | n6-DNA-methyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.6940 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.6940 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.6940 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.6940 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1401600 | Plasmodium berghei | Slow | plasmo |
TGME49_244240 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.