pI: 6.2195 |
Length (AA): 801 |
MW (Da): 87345 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 586 | 4p6z (G) | 5 | 587 | 37.00 | 0 | 1 | 1.20803 | -0.67 |
27 | 622 | 4uqi (B) | 10 | 620 | 15.00 | 0 | 1 | 0.846138 | 0.56 |
689 | 805 | 2a7b (A) | 705 | 815 | 27.00 | 0 | 1 | 0.430581 | -0.49 |
697 | 805 | 3zy7 (A) | 3 | 113 | 20.00 | 0.0000000052 | 1 | 0.445368 | -0.98 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127319)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G23900 | AP-1 complex subunit gamma-1 |
Arabidopsis thaliana | AT1G60070 | AP-1 complex subunit gamma-2 |
Babesia bovis | BBOV_II003680 | adaptin N terminal region family protein |
Brugia malayi | Bm1_49090 | gamma1-adaptin |
Candida albicans | CaO19.10363 | similar to S. cerevisiae APL4 (YPR029C) Gamma-Adaptin, large subunit of the clathrin-associated protein AP-2 complex |
Candida albicans | CaO19.2844 | similar to S. cerevisiae APL4 (YPR029C) Gamma-Adaptin, large subunit of the clathrin-associated protein AP-2 complex |
Caenorhabditis elegans | CELE_Y105E8A.9 | Protein APG-1 |
Cryptosporidium hominis | Chro.50468 | adaptor-related protein complex 1, gamma 2 subunit; gamma2-adaptin; clathrin-associated/assembly/adaptor protein, large, gamma-2 |
Cryptosporidium parvum | cgd5_3850 | adapter-protein complex 1 gamma subunit (gamma adaptin) |
Dictyostelium discoideum | DDB_G0281957 | AP-1 complex gamma 1 subunit |
Drosophila melanogaster | Dmel_CG9113 | Adaptor Protein complex 1, gamma subunit |
Echinococcus granulosus | EgrG_000669200 | AP 1 complex subunit gamma |
Entamoeba histolytica | EHI_196890 | gamma-adaptin, putative |
Echinococcus multilocularis | EmuJ_000669200 | AP 1 complex subunit gamma |
Giardia lamblia | GL50803_16364 | Gamma adaptin |
Homo sapiens | ENSG00000166747 | adaptor-related protein complex 1, gamma 1 subunit |
Homo sapiens | ENSG00000213983 | adaptor-related protein complex 1, gamma 2 subunit |
Leishmania braziliensis | LbrM.20.3600 | adaptor gamma-1 chain, putative |
Leishmania donovani | LdBPK_343800.1 | AP-1 adapter complex gamma subunit, putative |
Leishmania infantum | LinJ.34.3800 | adaptor gamma-1 chain, putative |
Leishmania major | LmjF.34.3970 | adaptor gamma-1 chain, putative |
Leishmania mexicana | LmxM.33.3970 | adaptor gamma-1 chain, putative |
Loa Loa (eye worm) | LOAG_06513 | gamma1-adaptin |
Loa Loa (eye worm) | LOAG_12234 | hypothetical protein |
Mus musculus | ENSMUSG00000031731 | adaptor protein complex AP-1, gamma 1 subunit |
Mus musculus | ENSMUSG00000040701 | adaptor protein complex AP-1, gamma 2 subunit |
Neospora caninum | NCLIV_056950 | hypothetical protein |
Oryza sativa | 4331060 | Os02g0805000 |
Oryza sativa | 4340249 | Os06g0167100 |
Plasmodium berghei | PBANKA_1319200 | AP-1 complex subunit gamma, putative |
Plasmodium falciparum | PF3D7_1455500 | AP-1 complex subunit gamma, putative |
Plasmodium knowlesi | PKNH_1226300 | AP-1 complex subunit gamma, putative |
Plasmodium vivax | PVX_117690 | AP-1 complex subunit gamma, putative |
Plasmodium yoelii | PY05746 | adapter-related protein complex 1 gamma 1 subunit |
Saccharomyces cerevisiae | YPR029C | Apl4p |
Schistosoma japonicum | Sjp_0066820 | AP-1 complex subunit gamma-1, putative |
Schistosoma mansoni | Smp_092530.1 | adapter-related protein complex 1 gamma subunit (gamma-adaptin) |
Schistosoma mansoni | Smp_092530.2 | adapter-related protein complex 1 gamma subunit (gamma-adaptin) |
Schmidtea mediterranea | mk4.001982.04 | Adaptor protein complex 1, gamma subunit |
Schmidtea mediterranea | mk4.000232.05 | AP-1 complex subunit gamma-like 2 |
Schmidtea mediterranea | mk4.000232.04 | Adaptor protein complex 1, gamma subunit |
Trypanosoma brucei gambiense | Tbg972.4.540 | AP-1 adapter complex gamma subunit, putative |
Trypanosoma brucei | Tb927.4.760 | AP-1 adapter complex gamma subunit, putative |
Trypanosoma cruzi | TcCLB.508257.260 | AP-1 adapter complex gamma subunit, putative |
Toxoplasma gondii | TGME49_313670 | adaptin n terminal region domain-containing protein |
Theileria parva | TP04_0213 | adaptin gamma subunit, putative |
Trichomonas vaginalis | TVAG_405400 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_344080 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_009720 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_248880 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_146900 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_077020 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_426420 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_387740 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_230820 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_459350 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_129070 | adaptin, alpha/gamma/epsilon, putative |
Trichomonas vaginalis | TVAG_448850 | adaptin, alpha/gamma/epsilon, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.760 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.760 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.760 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.4.760 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y105E8A.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_Y105E8A.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y105E8A.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y105E8A.9 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y105E8A.9 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1319200 | Plasmodium berghei | Essential | plasmo |
TGME49_313670 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.