Detailed view for Tb927.10.1170

Basic information

TDR Targets ID: 20172
Trypanosoma brucei, intraflagellar transport protein 172
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.9807 | Length (AA): 1747 | MW (Da): 196600 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130417)

Species Accession Gene Product
Caenorhabditis elegans CELE_T27B1.1   Protein OSM-1
Drosophila melanogaster Dmel_CG13809   Outer segment 2
Echinococcus granulosus EgrG_000617200   intraflagellar transport protein 172
Echinococcus multilocularis EmuJ_000617200   intraflagellar transport protein 172
Giardia lamblia GL50803_17105   IFT complex B
Homo sapiens ENSG00000138002   intraflagellar transport 172
Leishmania braziliensis LbrM.21.1210   hypothetical protein, conserved
Leishmania donovani LdBPK_211220.1   intraflagellar transport protein 172, putative
Leishmania infantum LinJ.21.1220   hypothetical protein, conserved
Leishmania major LmjF.21.0980   hypothetical protein, conserved
Leishmania mexicana LmxM.21.0980   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04604   hypothetical protein
Loa Loa (eye worm) LOAG_14257   hypothetical protein
Loa Loa (eye worm) LOAG_13357   hypothetical protein
Mus musculus ENSMUSG00000038564   intraflagellar transport 172
Neospora caninum NCLIV_040690   selective LIM-binding factor, putative
Schistosoma japonicum Sjp_0034460   Intraflagellar transport protein 172 homolog, putative
Schistosoma mansoni Smp_130830   wimple/ift172
Schmidtea mediterranea mk4.000070.26   IFT172-like protein
Trypanosoma brucei gambiense Tbg972.10.1210   hypothetical protein, conserved
Trypanosoma brucei Tb11.0560   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.1170   intraflagellar transport protein 172
Trypanosoma brucei Tb11.v5.0858   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_970   intraflagellar transport protein 172, putative
Trypanosoma cruzi TcCLB.509695.90   intraflagellar transport protein 172, putative
Toxoplasma gondii TGME49_288050   intraflagellar transport protein 172, putative
Trichomonas vaginalis TVAG_327960   wimple/ift172, putative
Trichomonas vaginalis TVAG_061760   osm-1, putative

Essentiality

Tb927.10.1170 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1170 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1170 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1170 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1170 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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User comments

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Gene identifier Tb927.10.1170 (Trypanosoma brucei), intraflagellar transport protein 172
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