Detailed view for PF3D7_1307800

Basic information

TDR Targets ID: 2037
Plasmodium falciparum, fork head domain protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.4896 | Length (AA): 561 | MW (Da): 68284 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00498   FHA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
446 553 1yjm (A) 5 104 14.00 0 0.39 0.29 -1.02
447 552 2aff (A) 3 98 27.00 0.00000000057 0.97 0.53 -0.79
3 174 4tql (A) 46 213 16.00 0.56 0 0.538295 -1.32
436 558 3vpy (A) 4 133 47.00 0.000000032 1 0.778951 -1.1
442 562 3vpy (A) 4 131 50.00 0 1 0.822504 -1.26
444 565 3vpy (A) 4 134 40.00 0.0000012 1 0.694868 -0.92
488 558 1mzk (A) 215 291 30.00 0.061 0.81 0.28592 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, late ring, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, sporozoite, early ring, early trophozoite, late schizont, late trophozoite, Ring, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile gametocyte, early schizont, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128999)

Species Accession Gene Product
Arabidopsis thaliana AT3G20550   FHA domain-containing protein DDL
Babesia bovis BBOV_III011470   FHA domain containing protein
Brugia malayi Bm1_47765   FHA domain containing protein
Caenorhabditis elegans CELE_C32E8.5   Protein C32E8.5
Cryptosporidium parvum cgd1_3470   fork head domain protein, putative
Drosophila melanogaster Dmel_CG17168   CG17168 gene product from transcript CG17168-RA
Echinococcus granulosus EgrG_000218600   Smad nuclear interacting protein 1
Entamoeba histolytica EHI_029080   FHA domain protein, putative
Echinococcus multilocularis EmuJ_000218600   Smad nuclear interacting protein 1
Homo sapiens ENSG00000163877   Smad nuclear interacting protein 1
Loa Loa (eye worm) LOAG_03856   FHA domain-containing protein
Mus musculus ENSMUSG00000050213   Smad nuclear interacting protein 1
Neospora caninum NCLIV_022960   GM13279, related
Oryza sativa 4339498   Os05g0545500
Oryza sativa 4339499   Os05g0545600
Oryza sativa 4339504   Os05g0546600
Plasmodium berghei PBANKA_1406300   fork head domain protein, putative
Plasmodium falciparum PF3D7_1307800   fork head domain protein, putative
Plasmodium knowlesi PKNH_1408200   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1408100   fork head domain protein, putative
Plasmodium vivax PVX_122222   hypothetical protein, conserved
Plasmodium vivax PVX_122218   fork head domain protein, putative
Plasmodium yoelii PY00031   Drosophila melanogaster RE68879p, putative
Saccharomyces cerevisiae YLR016C   Pml1p
Schistosoma japonicum Sjp_0205210   Smad nuclear-interacting protein 1, putative
Schistosoma mansoni Smp_137380   smad nuclear interacting protein
Schmidtea mediterranea mk4.005770.02   Smad nuclear-interacting protein 1
Toxoplasma gondii TGME49_201790   FHA domain-containing protein
Theileria parva TP02_0790   hypothetical protein
Trichomonas vaginalis TVAG_426690   smad nuclear interacting protein, putative

Essentiality

PF3D7_1307800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C32E8.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C32E8.5 Caenorhabditis elegans larval arrest wormbase
CELE_C32E8.5 Caenorhabditis elegans slow growth wormbase
TGME49_201790 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1307800 (Plasmodium falciparum), fork head domain protein, putative
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