Detailed view for PF3D7_1309400

Basic information

TDR Targets ID: 2044
Plasmodium falciparum, HORMA domain protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.2073 | Length (AA): 1327 | MW (Da): 158123 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02301   HORMA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0007067   mitosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 213 4tzq (A) 23 246 14.00 0.00096 0.73 0.359245 -0.81
748 949 4r5c (A) 60 302 29.00 0.16 0.12 0.0658231 1.09
808 979 4r58 (A) 24 215 26.00 0.15 0.69 0.321216 0.08
1069 1195 3k29 (A) 34 162 28.00 0.24 0.04 0.464305 -1.34
6 218 4tzm (A) 23 251 15.00 0.0062 0.41 0.337725 -0.71
809 1064 3uau (A) 63 359 31.00 0.19 0.21 -0.0324214 1.92
1038 1248 4tql (A) 9 221 16.00 0.002 0.09 0.408583 -1.11
1044 1178 3k29 (A) 34 162 27.00 0.25 0.03 0.450286 -1.22
1116 1295 4uos (A) 2 184 18.00 0.54 0.43 0.372682 -0.95

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile gametocyte, Female Gametocyte, Male Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile late schizont, late trophozoite, Ring. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile early trophozoite, Sporozoite. PlasmoDB Zanghi G
Show/Hide expression data references
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128667)

Species Accession Gene Product
Arabidopsis thaliana AT1G67370   asynaptic 1
Babesia bovis BBOV_II002160   HORMA domain containing protein
Brugia malayi Bm1_43185   Em:AC002378.1
Candida albicans CaO19.10816   DNA-binding protein, involved in meiosis
Candida albicans CaO19.3306   DNA-binding protein, involved in meiosis
Caenorhabditis elegans CELE_ZK381.1   Protein HIM-3
Cryptosporidium hominis Chro.50207   essential protein for meiotic synapsis
Cryptosporidium parvum cgd5_1750   conserved protein with N-terminal HORMA domain
Echinococcus granulosus EgrG_000163900   HORMA domain containing protein 2
Echinococcus multilocularis EmuJ_000163900   HORMA domain containing protein 2
Giardia lamblia GL50803_4084   Hop1
Homo sapiens ENSG00000176635   HORMA domain containing 2
Homo sapiens ENSG00000143452   HORMA domain containing 1
Leishmania braziliensis LbrM.35.1240   hypothetical protein, conserved
Leishmania donovani LdBPK_361170.1   HORMA domain containing protein, putative
Leishmania infantum LinJ.36.1170   hypothetical protein, conserved
Leishmania major LmjF.36.1110   hypothetical protein, conserved
Leishmania mexicana LmxM.36.1110   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_01638   hypothetical protein
Loa Loa (eye worm) LOAG_10393   hypothetical protein
Mus musculus ENSMUSG00000020419   HORMA domain containing 2
Mus musculus ENSMUSG00000028109   HORMA domain containing 1
Oryza sativa 4347514   Os09g0506800
Onchocerca volvulus OVOC1489  
Onchocerca volvulus OVOC10490  
Plasmodium berghei PBANKA_1407900   HORMA domain protein, putative
Plasmodium falciparum PF3D7_1309400   HORMA domain protein, putative
Plasmodium knowlesi PKNH_1409800   HORMA domain protein, putative
Plasmodium vivax PVX_122300   HORMA domain protein, putative
Plasmodium yoelii PY02325   HORMA domain, putative
Saccharomyces cerevisiae YIL072W   Hop1p
Schistosoma japonicum Sjp_0036110   HORMA domain-containing protein 2, putative
Schistosoma japonicum Sjp_0312300   expressed protein
Schistosoma mansoni Smp_169930   hypothetical protein
Schmidtea mediterranea mk4.001053.00  
Trypanosoma brucei gambiense Tbg972.10.6680   hypothetical protein, conserved,predicted HORMA domain protein
Trypanosoma brucei Tb927.10.5490   predicted HORMA domain protein
Trypanosoma congolense TcIL3000_10_4620   predicted HORMA domain protein
Trypanosoma cruzi TcCLB.503611.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506679.260   hypothetical protein, conserved
Toxoplasma gondii TGME49_291860   HORMA domain-containing protein
Theileria parva TP04_0349   hypothetical protein
Trichomonas vaginalis TVAG_230730   synaptonemal complex axial element Hop1

Essentiality

PF3D7_1309400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.5490 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.5490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.5490 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZK381.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_ZK381.1 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_1407900 Plasmodium berghei Dispensable plasmo
TGME49_291860 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1309400 (Plasmodium falciparum), HORMA domain protein, putative
Title for this comment
Comment