pI: 9.6886 |
Length (AA): 704 |
MW (Da): 77980 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 70 | 1ggz (A) | 9 | 76 | 9.00 | 0.00000015 | 0.07 | 0.235311 | -0.76 |
4 | 77 | 2e6w (A) | 166 | 250 | 14.00 | 0.079 | 0.17 | 0.164414 | -0.98 |
4 | 66 | 2doq (C) | 24 | 85 | 18.00 | 0.00012 | 0.34 | 0.392789 | -1.25 |
7 | 77 | 1sl8 (A) | 113 | 182 | 11.00 | 0.6 | 0.04 | 0.213152 | -0.34 |
111 | 382 | 1okc (A) | 7 | 280 | 34.00 | 0 | 0.94 | 0.658464 | 0.55 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126987)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G01100 | adenine nucleotide transporter 1 |
Arabidopsis thaliana | AT4G26180 | mitochondrial substrate carrier family protein |
Arabidopsis thaliana | AT1G14560 | mitochondrial CoA transporter |
Brugia malayi | Bm1_28425 | Mitochondrial carrier protein |
Candida albicans | CaO19.2117 | likel mitochondrial carrier protein similar to S. cerevisiae LEU5 (YHR002W) involved in coenzyme A transport |
Candida albicans | CaO19.804 | potential mitochondrial carrier protein similar to S. cerevisiae YPR011C |
Candida albicans | CaO19.8422 | potential mitochondrial carrier protein similar to S. cerevisiae YPR011C |
Candida albicans | CaO19.9665 | likel mitochondrial carrier protein similar to S. cerevisiae LEU5 (YHR002W) involved in coenzyme A transport |
Caenorhabditis elegans | CELE_F43G9.3 | Protein F43G9.3 |
Dictyostelium discoideum | DDB_G0285599 | EF-hand domain-containing protein |
Dictyostelium discoideum | DDB_G0283811 | mitochondrial substrate carrier family protein |
Dictyostelium discoideum | DDB_G0292034 | Graves disease carrier family protein |
Drosophila melanogaster | Dmel_CG4241 | alternative testis transcripts open reading frame A |
Echinococcus granulosus | EgrG_000446900 | solute carrier family 25 2 |
Echinococcus multilocularis | EmuJ_000446900 | solute carrier family 25 2 |
Homo sapiens | 8034 | solute carrier family 25 (mitochondrial carrier), member 16 |
Homo sapiens | ENSG00000181035 | solute carrier family 25, member 42 |
Leishmania braziliensis | LbrM.35.0600 | mitochondrial carrier protein, putative |
Leishmania donovani | LdBPK_360540.1 | mitochondrial carrier protein, putative |
Leishmania infantum | LinJ.36.0540 | mitochondrial carrier protein, putative |
Leishmania major | LmjF.36.0510 | mitochondrial carrier protein, putative |
Leishmania mexicana | LmxM.36.0510 | mitochondrial carrier protein, putative |
Loa Loa (eye worm) | LOAG_09735 | carrier protein |
Mus musculus | ENSMUSG00000071253 | solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 |
Mus musculus | ENSMUSG00000002346 | solute carrier family 25, member 42 |
Neospora caninum | NCLIV_034240 | hypothetical protein |
Oryza sativa | 4327687 | Os01g0708900 |
Oryza sativa | 4326348 | Os01g0571000 |
Oryza sativa | 4339755 | Os05g0585900 |
Oryza sativa | 4328656 | Os02g0202400 |
Oryza sativa | 4328781 | Os02g0226300 |
Onchocerca volvulus | OVOC1356 | Mitochondrial coenzyme A transporter SLC25A42 homolog |
Saccharomyces cerevisiae | YPR011C | hypothetical protein |
Saccharomyces cerevisiae | YHR002W | Leu5p |
Schistosoma japonicum | Sjp_0303720 | Solute carrier family 25 member 42, putative |
Schistosoma mansoni | Smp_142930 | mitochondrial carrier protein |
Schmidtea mediterranea | mk4.001400.01 | Graves disease carrier protein |
Schmidtea mediterranea | mk4.001400.03 | |
Schmidtea mediterranea | mk4.004495.01 | |
Schmidtea mediterranea | mk4.008978.01 | |
Trypanosoma brucei gambiense | Tbg972.10.5960 | mitochondrial carrier protein, putative |
Trypanosoma brucei | Tb927.10.4910 | mitochondrial carrier protein |
Trypanosoma congolense | TcIL3000_10_4100 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.510291.14 | mitochondrial carrier protein, putative |
Trypanosoma cruzi | TcCLB.508659.18 | mitochondrial carrier protein, putative |
Toxoplasma gondii | TGME49_273390 | mitochondrial carrier superfamily protein |
Trichomonas vaginalis | TVAG_262210 | tricarboxylate transport protein, putative |
Trichomonas vaginalis | TVAG_051820 | tricarboxylate transport protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.4910 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.4910 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.4910 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.4910 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F43G9.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F43G9.3 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_273390 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
1 literature reference was collected for this gene.