Detailed view for PF3D7_1311100

Basic information

TDR Targets ID: 2053
Plasmodium falciparum, meiosis-specific nuclear structural protein 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.5087 | Length (AA): 495 | MW (Da): 61232 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13868   Trichohyalin-plectin-homology domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 97 2i1k (A) 336 441 13.00 0.12 0 0.500239 -2.15
80 283 4uos (A) 0 184 31.00 0.017 0.95 0.690721 -0.66
108 358 4tql (A) 10 238 30.00 0.000047 0.97 0.774671 -0.63
2 107 2i1k (A) 336 451 12.00 0.027 0 0.480941 -1.79
80 283 4uos (A) 0 184 31.00 0.0097 0.99 0.691521 -0.63
108 358 4tql (A) 10 238 30.00 0.000049 0.99 0.764471 -0.51
125 358 4tql (A) 10 238 22.00 0.00000002 0.42 0.795327 -1.33

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, gametocyte, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, Oocyst, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130109)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG7352   CG7352 gene product from transcript CG7352-RC
Giardia lamblia GL50803_16267   Hypothetical protein
Homo sapiens ENSG00000138587   meiosis-specific nuclear structural 1
Leishmania braziliensis LbrM.30.3160   hypothetical protein, conserved
Leishmania donovani LdBPK_303210.1   Tumour suppressor, Mitostatin, putative
Leishmania infantum LinJ.30.3210   hypothetical protein, conserved
Leishmania major LmjF.30.3170   hypothetical protein, conserved
Leishmania mexicana LmxM.29.3170   hypothetical protein, conserved
Mus musculus 17427   meiosis-specific nuclear structural protein 1
Neospora caninum NCLIV_049280   Trichohyalin, related
Plasmodium berghei PBANKA_1409600   meiosis-specific nuclear structural protein 1, putative
Plasmodium falciparum PF3D7_1311100   meiosis-specific nuclear structural protein 1, putative
Plasmodium knowlesi PKNH_1411500   meiosis-specific nuclear structural protein 1, putative
Plasmodium vivax PVX_122385   hypothetical protein, conserved
Plasmodium yoelii PY02801   unnamed protein product, putative
Schistosoma japonicum Sjp_0034740   Meiosis-specific nuclear structural protein 1, putative
Schistosoma mansoni Smp_068350   hypothetical protein
Schmidtea mediterranea mk4.005183.04  
Trypanosoma brucei gambiense Tbg972.6.4300   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.4520   Tumour suppressor, Mitostatin, putative
Trypanosoma congolense TcIL3000_0_03160   Tumour suppressor, Mitostatin, putative
Trypanosoma congolense TcIL3000_6_3960   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509167.60   Tumour suppressor, Mitostatin, putative
Toxoplasma gondii TGME49_212075   hypothetical protein
Trichomonas vaginalis TVAG_123230   Inner centromere protein, putative
Trichomonas vaginalis TVAG_187340   ubiquitin-protein ligase BRE1A, putative

Essentiality

PF3D7_1311100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.4520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.4520 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.4520 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.4520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1409600 Plasmodium berghei Dispensable plasmo
TGME49_212075 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1311100 (Plasmodium falciparum), meiosis-specific nuclear structural protein 1, putative
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