Detailed view for Tb927.10.6060
Basic information
TDR Targets ID: 20606
Trypanosoma brucei, universal minicircle sequence binding protein 2
Source Database / ID: TriTrypDB GeneDB
Trypanosoma brucei, universal minicircle sequence binding protein 2
Source Database / ID: TriTrypDB GeneDB
pI: 8.3055 |
Length (AA): 213 |
MW (Da): 21836 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00098
Zinc knuckle
Gene Ontology
Mouse over links to read term descriptions.
GO:0008270
zinc ion binding GO:0003676 nucleic acid binding
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
No model available for this protein in Modbase.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| NA% percentile | Procyclic, Bloodstream Form. | Siegel TN |
-
Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.
Orthologs
Ortholog group members (OG5_128115)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT2G17870 | cold shock domain protein 3 |
| Arabidopsis thaliana | AT1G75560 | CCHC-type zinc knuckle protein |
| Arabidopsis thaliana | AT4G36020 | cold shock protein 1 |
| Brugia malayi | Bm1_26265 | Zinc knuckle family protein |
| Candida albicans | CaO19.10692 | nucleic acid binding protein |
| Candida albicans | CaO19.3182 | nucleic acid binding protein |
| Caenorhabditis elegans | CELE_K08D12.3 | Protein K08D12.3, isoform B |
| Dictyostelium discoideum | DDB_G0293328 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG3800 | CG3800 gene product from transcript CG3800-RA |
| Echinococcus multilocularis | EmuJ_000891600 | universal minicircle sequence binding protein (UMSBP) |
| Homo sapiens | 7555 | CCHC-type zinc finger, nucleic acid binding protein |
| Leishmania braziliensis | LbrM.35.1830 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania donovani | LdBPK_361720.1 | universal minicircle sequence binding protein, putative |
| Leishmania infantum | LinJ.36.1720 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania major | LmjF.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania mexicana | LmxM.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
| Mus musculus | ENSMUSG00000030057 | cellular nucleic acid binding protein |
| Mus musculus | ENSMUSG00000031330 | zinc finger, CCHC domain containing 13 |
| Oryza sativa | 4334596 | Os03g0820700 |
| Oryza sativa | 4349279 | Os10g0545300 |
| Saccharomyces cerevisiae | YNL255C | Gis2p |
| Schistosoma japonicum | Sjp_0200160 | ko:K09250 cellular nucleic acid-binding protein, putative |
| Schistosoma mansoni | Smp_179300.3 | cellular nucleic acid binding protein |
| Schistosoma mansoni | Smp_179300.2 | cellular nucleic acid binding protein |
| Schistosoma mansoni | Smp_179300.1 | cellular nucleic acid binding protein |
| Schmidtea mediterranea | mk4.028203.00 | |
| Schmidtea mediterranea | mk4.010278.00 | |
| Schmidtea mediterranea | mk4.009839.00 | |
| Schmidtea mediterranea | mk4.031374.00 | |
| Schmidtea mediterranea | mk4.028847.00 | |
| Schmidtea mediterranea | mk4.026437.00 | |
| Schmidtea mediterranea | mk4.032846.00 | |
| Schmidtea mediterranea | mk4.035748.00 | |
| Schmidtea mediterranea | mk4.032585.00 | |
| Schmidtea mediterranea | mk4.004918.00 | |
| Schmidtea mediterranea | mk4.002757.04 | |
| Schmidtea mediterranea | mk4.013224.01 | |
| Schmidtea mediterranea | mk4.000820.00 | |
| Schmidtea mediterranea | mk4.001718.00 | |
| Schmidtea mediterranea | mk4.015551.00 | |
| Schmidtea mediterranea | mk4.024254.00 | |
| Schmidtea mediterranea | mk4.000835.00 | |
| Schmidtea mediterranea | mk4.028647.00 | |
| Schmidtea mediterranea | mk4.003828.00 | |
| Schmidtea mediterranea | mk4.013803.02 | |
| Schmidtea mediterranea | mk4.034705.00 | |
| Schmidtea mediterranea | mk4.000931.06 | |
| Schmidtea mediterranea | mk4.001222.05 | |
| Schmidtea mediterranea | mk4.016740.00 | |
| Schmidtea mediterranea | mk4.024256.00 | |
| Schmidtea mediterranea | mk4.005496.00 | |
| Schmidtea mediterranea | mk4.023252.00 | |
| Schmidtea mediterranea | mk4.008859.00 | |
| Schmidtea mediterranea | mk4.011026.00 | |
| Schmidtea mediterranea | mk4.005785.02 | |
| Schmidtea mediterranea | mk4.020264.00 | |
| Schmidtea mediterranea | mk4.023946.00 | |
| Schmidtea mediterranea | mk4.006325.00 | |
| Schmidtea mediterranea | mk4.025590.00 | |
| Schmidtea mediterranea | mk4.030497.00 | |
| Schmidtea mediterranea | mk4.032286.00 | |
| Schmidtea mediterranea | mk4.024201.00 | |
| Schmidtea mediterranea | mk4.029030.00 | |
| Schmidtea mediterranea | mk4.006869.00 | |
| Schmidtea mediterranea | mk4.028385.00 | |
| Schmidtea mediterranea | mk4.038041.00 | |
| Schmidtea mediterranea | mk4.014408.00 | |
| Schmidtea mediterranea | mk4.029997.00 | |
| Schmidtea mediterranea | mk4.028085.00 | |
| Schmidtea mediterranea | mk4.005921.01 | |
| Schmidtea mediterranea | mk4.016807.00 | |
| Schmidtea mediterranea | mk4.000792.10 | |
| Schmidtea mediterranea | mk4.001859.01 | |
| Schmidtea mediterranea | mk4.028797.00 | |
| Schmidtea mediterranea | mk4.004330.00 | |
| Schmidtea mediterranea | mk4.014863.01 | |
| Schmidtea mediterranea | mk4.007140.01 | |
| Schmidtea mediterranea | mk4.024882.00 | |
| Schmidtea mediterranea | mk4.032010.00 | |
| Schmidtea mediterranea | mk4.020038.00 | |
| Schmidtea mediterranea | mk4.004032.03 | |
| Schmidtea mediterranea | mk4.002337.00 | |
| Schmidtea mediterranea | mk4.016990.00 | |
| Schmidtea mediterranea | mk4.010503.00 | |
| Schmidtea mediterranea | mk4.035109.00 | |
| Schmidtea mediterranea | mk4.055251.00 | |
| Schmidtea mediterranea | mk4.026833.00 | |
| Schmidtea mediterranea | mk4.026975.00 | |
| Schmidtea mediterranea | mk4.023115.00 | |
| Schmidtea mediterranea | mk4.015156.01 | |
| Schmidtea mediterranea | mk4.013701.00 | |
| Schmidtea mediterranea | mk4.019947.01 | |
| Schmidtea mediterranea | mk4.000010.21 | |
| Schmidtea mediterranea | mk4.007341.04 | |
| Schmidtea mediterranea | mk4.000098.08 | |
| Schmidtea mediterranea | mk4.029081.00 | |
| Schmidtea mediterranea | mk4.000024.12 | |
| Schmidtea mediterranea | mk4.029968.00 | |
| Schmidtea mediterranea | mk4.014117.00 | |
| Schmidtea mediterranea | mk4.035233.00 | |
| Schmidtea mediterranea | mk4.031273.00 | |
| Schmidtea mediterranea | mk4.043113.00 | |
| Schmidtea mediterranea | mk4.004739.00 | |
| Schmidtea mediterranea | mk4.007927.01 | |
| Schmidtea mediterranea | mk4.004164.03 | |
| Schmidtea mediterranea | mk4.010855.00 | |
| Schmidtea mediterranea | mk4.034910.00 | |
| Schmidtea mediterranea | mk4.005397.02 | |
| Schmidtea mediterranea | mk4.029830.00 | |
| Schmidtea mediterranea | mk4.028720.00 | |
| Schmidtea mediterranea | mk4.029077.00 | |
| Schmidtea mediterranea | mk4.017871.01 | |
| Schmidtea mediterranea | mk4.016266.00 | |
| Schmidtea mediterranea | mk4.002500.01 | |
| Schmidtea mediterranea | mk4.000143.02 | |
| Schmidtea mediterranea | mk4.028465.01 | |
| Schmidtea mediterranea | mk4.001671.01 | |
| Schmidtea mediterranea | mk4.010936.00 | |
| Schmidtea mediterranea | mk4.000061.12 | |
| Schmidtea mediterranea | mk4.028413.00 | |
| Schmidtea mediterranea | mk4.041748.00 | |
| Schmidtea mediterranea | mk4.036434.00 | |
| Schmidtea mediterranea | mk4.024435.00 | |
| Schmidtea mediterranea | mk4.029562.00 | Putative uncharacterized protein |
| Schmidtea mediterranea | mk4.022772.00 | |
| Schmidtea mediterranea | mk4.004818.00 | |
| Schmidtea mediterranea | mk4.019827.00 | |
| Schmidtea mediterranea | mk4.003270.02 | |
| Schmidtea mediterranea | mk4.000455.06 | |
| Schmidtea mediterranea | mk4.019685.00 | |
| Schmidtea mediterranea | mk4.000400.08 | |
| Schmidtea mediterranea | mk4.000165.21 | |
| Schmidtea mediterranea | mk4.024591.00 | |
| Schmidtea mediterranea | mk4.028326.00 | |
| Schmidtea mediterranea | mk4.002388.01 | |
| Schmidtea mediterranea | mk4.039915.00 | |
| Schmidtea mediterranea | mk4.004700.01 | |
| Schmidtea mediterranea | mk4.031764.00 | |
| Schmidtea mediterranea | mk4.001916.04 | |
| Schmidtea mediterranea | mk4.032169.00 | |
| Schmidtea mediterranea | mk4.001461.08 | |
| Schmidtea mediterranea | mk4.002537.02 | |
| Schmidtea mediterranea | mk4.071856.00 | |
| Schmidtea mediterranea | mk4.000772.01 | |
| Schmidtea mediterranea | mk4.016498.01 | |
| Schmidtea mediterranea | mk4.000293.02 | |
| Schmidtea mediterranea | mk4.036604.00 | |
| Schmidtea mediterranea | mk4.000056.10 | |
| Schmidtea mediterranea | mk4.012431.02 | |
| Schmidtea mediterranea | mk4.025722.00 | |
| Schmidtea mediterranea | mk4.029635.00 | |
| Schmidtea mediterranea | mk4.026866.00 | |
| Schmidtea mediterranea | mk4.028127.00 | |
| Schmidtea mediterranea | mk4.030438.00 | |
| Schmidtea mediterranea | mk4.002916.02 | |
| Schmidtea mediterranea | mk4.035931.00 | |
| Schmidtea mediterranea | mk4.026090.00 | |
| Schmidtea mediterranea | mk4.028400.00 | |
| Schmidtea mediterranea | mk4.004102.01 | |
| Schmidtea mediterranea | mk4.025060.00 | |
| Schmidtea mediterranea | mk4.008282.01 | |
| Schmidtea mediterranea | mk4.001514.01 | |
| Schmidtea mediterranea | mk4.007511.02 | |
| Schmidtea mediterranea | mk4.017023.00 | |
| Schmidtea mediterranea | mk4.032035.00 | |
| Schmidtea mediterranea | mk4.028777.00 | |
| Schmidtea mediterranea | mk4.017520.01 | |
| Schmidtea mediterranea | mk4.005425.00 | |
| Schmidtea mediterranea | mk4.004488.00 | |
| Schmidtea mediterranea | mk4.020475.00 | |
| Schmidtea mediterranea | mk4.001388.03 | Phosphomevalonate kinase |
| Schmidtea mediterranea | mk4.000978.04 | |
| Schmidtea mediterranea | mk4.000144.06 | |
| Schmidtea mediterranea | mk4.034857.00 | |
| Schmidtea mediterranea | mk4.002604.01 | |
| Schmidtea mediterranea | mk4.038013.00 | |
| Schmidtea mediterranea | mk4.028790.00 | |
| Schmidtea mediterranea | mk4.026618.00 | |
| Schmidtea mediterranea | mk4.041137.00 | |
| Schmidtea mediterranea | mk4.029101.00 | |
| Schmidtea mediterranea | mk4.020533.00 | |
| Schmidtea mediterranea | mk4.024831.00 | |
| Schmidtea mediterranea | mk4.009788.00 | |
| Schmidtea mediterranea | mk4.000362.13 | |
| Schmidtea mediterranea | mk4.005174.04 | |
| Schmidtea mediterranea | mk4.033927.00 | |
| Schmidtea mediterranea | mk4.029861.01 | |
| Schmidtea mediterranea | mk4.023029.00 | |
| Schmidtea mediterranea | mk4.000705.08 | |
| Schmidtea mediterranea | mk4.005203.03 | |
| Schmidtea mediterranea | mk4.026392.00 | |
| Schmidtea mediterranea | mk4.031994.00 | |
| Schmidtea mediterranea | mk4.009272.00 | |
| Schmidtea mediterranea | mk4.029873.00 | |
| Schmidtea mediterranea | mk4.030579.00 | |
| Schmidtea mediterranea | mk4.012359.00 | |
| Schmidtea mediterranea | mk4.002862.04 | |
| Schmidtea mediterranea | mk4.004808.01 | |
| Schmidtea mediterranea | mk4.006871.01 | |
| Schmidtea mediterranea | mk4.028211.00 | |
| Schmidtea mediterranea | mk4.022350.00 | |
| Schmidtea mediterranea | mk4.034239.00 | |
| Schmidtea mediterranea | mk4.013291.00 | |
| Schmidtea mediterranea | mk4.027747.00 | |
| Schmidtea mediterranea | mk4.044676.00 | |
| Schmidtea mediterranea | mk4.000586.05 | |
| Schmidtea mediterranea | mk4.036519.00 | |
| Schmidtea mediterranea | mk4.017480.00 | |
| Schmidtea mediterranea | mk4.028941.00 | |
| Schmidtea mediterranea | mk4.002695.06 | |
| Schmidtea mediterranea | mk4.001006.03 | |
| Schmidtea mediterranea | mk4.014394.00 | |
| Schmidtea mediterranea | mk4.007667.00 | |
| Schmidtea mediterranea | mk4.019883.00 | |
| Schmidtea mediterranea | mk4.005643.00 | |
| Schmidtea mediterranea | mk4.001549.00 | |
| Schmidtea mediterranea | mk4.026719.00 | |
| Schmidtea mediterranea | mk4.002620.03 | |
| Schmidtea mediterranea | mk4.000812.04 | |
| Schmidtea mediterranea | mk4.018537.00 | |
| Schmidtea mediterranea | mk4.031934.00 | |
| Schmidtea mediterranea | mk4.034027.00 | |
| Schmidtea mediterranea | mk4.001451.02 | |
| Schmidtea mediterranea | mk4.004186.02 | |
| Schmidtea mediterranea | mk4.003311.02 | |
| Schmidtea mediterranea | mk4.024178.00 | |
| Schmidtea mediterranea | mk4.002555.02 | |
| Schmidtea mediterranea | mk4.029919.00 | |
| Schmidtea mediterranea | mk4.005955.01 | |
| Schmidtea mediterranea | mk4.027584.00 | |
| Schmidtea mediterranea | mk4.001183.01 | |
| Schmidtea mediterranea | mk4.000221.01 | |
| Schmidtea mediterranea | mk4.031697.00 | |
| Schmidtea mediterranea | mk4.001313.07 | |
| Schmidtea mediterranea | mk4.031428.00 | |
| Schmidtea mediterranea | mk4.003097.00 | |
| Schmidtea mediterranea | mk4.027403.00 | |
| Schmidtea mediterranea | mk4.033652.00 | |
| Schmidtea mediterranea | mk4.032452.00 | |
| Schmidtea mediterranea | mk4.003085.02 | |
| Schmidtea mediterranea | mk4.026032.00 | |
| Schmidtea mediterranea | mk4.002193.04 | |
| Schmidtea mediterranea | mk4.025436.00 | |
| Schmidtea mediterranea | mk4.027781.00 | |
| Schmidtea mediterranea | mk4.008149.00 | |
| Schmidtea mediterranea | mk4.022144.00 | |
| Schmidtea mediterranea | mk4.035394.00 | |
| Schmidtea mediterranea | mk4.029015.00 | |
| Schmidtea mediterranea | mk4.024029.00 | |
| Schmidtea mediterranea | mk4.039830.00 | |
| Schmidtea mediterranea | mk4.028141.00 | |
| Schmidtea mediterranea | mk4.016265.00 | |
| Schmidtea mediterranea | mk4.023772.00 | |
| Schmidtea mediterranea | mk4.002746.00 | |
| Schmidtea mediterranea | mk4.003149.01 | |
| Schmidtea mediterranea | mk4.002120.06 | |
| Schmidtea mediterranea | mk4.032929.00 | |
| Schmidtea mediterranea | mk4.031928.00 | |
| Schmidtea mediterranea | mk4.026597.00 | |
| Schmidtea mediterranea | mk4.018118.00 | |
| Schmidtea mediterranea | mk4.022993.00 | |
| Schmidtea mediterranea | mk4.044067.00 | |
| Schmidtea mediterranea | mk4.020412.00 | |
| Schmidtea mediterranea | mk4.029963.00 | |
| Schmidtea mediterranea | mk4.024910.01 | |
| Schmidtea mediterranea | mk4.000248.06 | |
| Schmidtea mediterranea | mk4.024357.00 | |
| Schmidtea mediterranea | mk4.018287.00 | |
| Schmidtea mediterranea | mk4.009081.00 | |
| Schmidtea mediterranea | mk4.017267.00 | |
| Schmidtea mediterranea | mk4.000238.13 | |
| Schmidtea mediterranea | mk4.031471.00 | |
| Schmidtea mediterranea | mk4.027891.00 | |
| Schmidtea mediterranea | mk4.026091.00 | |
| Schmidtea mediterranea | mk4.027102.00 | |
| Schmidtea mediterranea | mk4.001109.01 | |
| Schmidtea mediterranea | mk4.023441.00 | |
| Schmidtea mediterranea | mk4.022830.00 | |
| Schmidtea mediterranea | mk4.038532.00 | |
| Schmidtea mediterranea | mk4.042813.00 | |
| Schmidtea mediterranea | mk4.008673.00 | |
| Schmidtea mediterranea | mk4.008134.00 | |
| Schmidtea mediterranea | mk4.000025.11 | |
| Schmidtea mediterranea | mk4.003740.00 | |
| Schmidtea mediterranea | mk4.000302.15 | |
| Schmidtea mediterranea | mk4.033632.00 | |
| Schmidtea mediterranea | mk4.006055.01 | |
| Schmidtea mediterranea | mk4.025305.00 | |
| Schmidtea mediterranea | mk4.006765.03 | |
| Schmidtea mediterranea | mk4.002191.01 | |
| Schmidtea mediterranea | mk4.022370.00 | |
| Schmidtea mediterranea | mk4.030145.00 | |
| Schmidtea mediterranea | mk4.016518.00 | |
| Schmidtea mediterranea | mk4.002149.14 | |
| Schmidtea mediterranea | mk4.021119.00 | |
| Schmidtea mediterranea | mk4.041592.00 | |
| Schmidtea mediterranea | mk4.024120.00 | |
| Schmidtea mediterranea | mk4.004295.04 | |
| Schmidtea mediterranea | mk4.000658.04 | |
| Schmidtea mediterranea | mk4.028703.01 | |
| Schmidtea mediterranea | mk4.026499.00 | |
| Schmidtea mediterranea | mk4.017468.00 | |
| Schmidtea mediterranea | mk4.006024.03 | |
| Schmidtea mediterranea | mk4.033666.00 | |
| Schmidtea mediterranea | mk4.003698.03 | |
| Schmidtea mediterranea | mk4.032339.00 | |
| Schmidtea mediterranea | mk4.028349.00 | |
| Schmidtea mediterranea | mk4.023747.00 | |
| Schmidtea mediterranea | mk4.001315.02 | |
| Schmidtea mediterranea | mk4.029250.00 | |
| Schmidtea mediterranea | mk4.007809.00 | |
| Schmidtea mediterranea | mk4.011760.02 | |
| Schmidtea mediterranea | mk4.026494.01 | |
| Schmidtea mediterranea | mk4.024245.00 | |
| Schmidtea mediterranea | mk4.026310.00 | |
| Schmidtea mediterranea | mk4.006294.00 | |
| Schmidtea mediterranea | mk4.044446.00 | |
| Schmidtea mediterranea | mk4.011619.00 | |
| Schmidtea mediterranea | mk4.029724.00 | |
| Schmidtea mediterranea | mk4.030395.00 | |
| Schmidtea mediterranea | mk4.006804.00 | |
| Schmidtea mediterranea | mk4.000750.02 | |
| Schmidtea mediterranea | mk4.004085.00 | |
| Schmidtea mediterranea | mk4.021137.00 | |
| Schmidtea mediterranea | mk4.029451.00 | |
| Schmidtea mediterranea | mk4.021549.00 | |
| Schmidtea mediterranea | mk4.006885.01 | |
| Schmidtea mediterranea | mk4.012368.01 | |
| Schmidtea mediterranea | mk4.007896.02 | |
| Schmidtea mediterranea | mk4.003195.03 | |
| Schmidtea mediterranea | mk4.027825.00 | |
| Schmidtea mediterranea | mk4.030209.00 | |
| Schmidtea mediterranea | mk4.012754.03 | |
| Schmidtea mediterranea | mk4.002779.00 | |
| Schmidtea mediterranea | mk4.004636.01 | |
| Schmidtea mediterranea | mk4.020374.00 | |
| Schmidtea mediterranea | mk4.029141.00 | |
| Schmidtea mediterranea | mk4.008388.00 | |
| Schmidtea mediterranea | mk4.028814.00 | |
| Schmidtea mediterranea | mk4.001841.05 | |
| Schmidtea mediterranea | mk4.029615.00 | |
| Schmidtea mediterranea | mk4.005085.01 | |
| Schmidtea mediterranea | mk4.000175.03 | |
| Schmidtea mediterranea | mk4.001149.07 | |
| Schmidtea mediterranea | mk4.013094.00 | |
| Schmidtea mediterranea | mk4.000729.12 | |
| Schmidtea mediterranea | mk4.020567.00 | |
| Schmidtea mediterranea | mk4.005420.03 | |
| Schmidtea mediterranea | mk4.015074.00 | |
| Schmidtea mediterranea | mk4.023428.00 | |
| Schmidtea mediterranea | mk4.001161.01 | |
| Schmidtea mediterranea | mk4.005260.03 | |
| Schmidtea mediterranea | mk4.030350.00 | |
| Schmidtea mediterranea | mk4.003209.01 | |
| Schmidtea mediterranea | mk4.003046.00 | |
| Schmidtea mediterranea | mk4.012732.02 | |
| Schmidtea mediterranea | mk4.023497.00 | |
| Schmidtea mediterranea | mk4.020216.00 | |
| Schmidtea mediterranea | mk4.004796.01 | |
| Schmidtea mediterranea | mk4.034770.00 | |
| Schmidtea mediterranea | mk4.023095.00 | |
| Schmidtea mediterranea | mk4.009833.01 | |
| Schmidtea mediterranea | mk4.000050.12 | |
| Schmidtea mediterranea | mk4.002234.00 | |
| Schmidtea mediterranea | mk4.031002.00 | |
| Schmidtea mediterranea | mk4.007962.00 | |
| Schmidtea mediterranea | mk4.012187.00 | |
| Schmidtea mediterranea | mk4.029463.00 | |
| Schmidtea mediterranea | mk4.029337.01 | |
| Schmidtea mediterranea | mk4.021360.00 | |
| Schmidtea mediterranea | mk4.029588.00 | |
| Schmidtea mediterranea | mk4.021962.00 | |
| Schmidtea mediterranea | mk4.002882.01 | |
| Schmidtea mediterranea | mk4.026054.00 | |
| Schmidtea mediterranea | mk4.027034.00 | |
| Schmidtea mediterranea | mk4.029438.00 | |
| Schmidtea mediterranea | mk4.000797.01 | |
| Schmidtea mediterranea | mk4.022513.00 | |
| Schmidtea mediterranea | mk4.023415.00 | |
| Schmidtea mediterranea | mk4.023770.00 | |
| Schmidtea mediterranea | mk4.036458.00 | |
| Schmidtea mediterranea | mk4.026692.00 | |
| Schmidtea mediterranea | mk4.035136.00 | |
| Schmidtea mediterranea | mk4.033856.00 | |
| Schmidtea mediterranea | mk4.027243.00 | |
| Schmidtea mediterranea | mk4.031080.00 | |
| Schmidtea mediterranea | mk4.008442.00 | |
| Schmidtea mediterranea | mk4.026933.00 | |
| Schmidtea mediterranea | mk4.006538.00 | |
| Schmidtea mediterranea | mk4.000098.04 | |
| Schmidtea mediterranea | mk4.026197.00 | |
| Schmidtea mediterranea | mk4.021994.00 | |
| Schmidtea mediterranea | mk4.001704.03 | |
| Schmidtea mediterranea | mk4.015054.00 | |
| Schmidtea mediterranea | mk4.000433.01 | |
| Schmidtea mediterranea | mk4.033315.00 | |
| Schmidtea mediterranea | mk4.017735.00 | CCHC-type zinc finger protein CG3800 |
| Trypanosoma brucei gambiense | Tbg972.10.7420 | universal minicircle sequence binding protein, putative |
| Trypanosoma brucei | Tb927.10.6060 | universal minicircle sequence binding protein 2 |
| Trypanosoma cruzi | TcCLB.503781.90 | universal minicircle sequence binding protein 2, putative |
| Trypanosoma cruzi | TcCLB.507639.20 | universal minicircle sequence binding protein, putative |
Essentiality
Tb927.10.6060 has direct evidence of essentiality
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.10.6060 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.10.6060 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.10.6060 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.10.6060 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_K08D12.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K08D12.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K08D12.3 | Caenorhabditis elegans | slow growth | wormbase |
-
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
Phenotypes and Validation (curated)
Annotated phenotypes:
| Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
|---|---|---|---|---|---|---|
| cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
| Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
| cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
| Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 | |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
1 literature reference was collected for this gene.
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User comments
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