Detailed view for PF3D7_1314500

Basic information

TDR Targets ID: 2075
Plasmodium falciparum, cop-coated vesicle membrane protein p24 precursor, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.2551 | Length (AA): 206 | MW (Da): 24443 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01105   emp24/gp25L/p24 family/GOLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0006810   transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, early schizont, early trophozoite, late trophozoite, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127521)

Species Accession Gene Product
Arabidopsis thaliana AT3G22845   transmembrane emp24 domain-containing protein p24beta3
Babesia bovis BBOV_IV006450   conserved hypothetical protein
Brugia malayi Bm1_45445   Suppressor/enhancer of lin-12 protein 9 precursor, putative
Candida albicans CaO19.3889   component of COPII-coated ER-derived vesicles
Candida albicans CaO19.13672   component of COPII-coated, ER transport vesicles
Candida albicans CaO19.6293   component of COPII-coated, ER transport vesicles
Candida albicans CaO19.11370   component of COPII-coated ER-derived vesicles
Candida albicans CaO19.3558   protein involved in membrane trafficking.
Candida albicans CaO19.11042   protein involved in membrane trafficking.
Caenorhabditis elegans CELE_W02D7.7   Protein SEL-9
Cryptosporidium hominis Chro.70216   CG9308-PA
Cryptosporidium parvum cgd7_1860   P24 like gold domain protein, possible transmembrane region near C-terminus, signal peptide
Dictyostelium discoideum DDB_G0293540   hypothetical protein
Dictyostelium discoideum DDB_G0288053   hypothetical protein
Drosophila melanogaster Dmel_CG9308   CG9308 gene product from transcript CG9308-RA
Drosophila melanogaster Dmel_CG3564   CG3564 gene product from transcript CG3564-RB
Echinococcus granulosus EgrG_000574700   transmembrane emp24 domain containing protein
Entamoeba histolytica EHI_096210   Coated vesicle membrane protein, putative
Entamoeba histolytica EHI_038590   hypothetical protein
Echinococcus multilocularis EmuJ_000574700   transmembrane emp24 domain containing protein
Giardia lamblia GL50803_4509   ERP1
Homo sapiens ENSG00000086598   transmembrane emp24 domain trafficking protein 2
Leishmania braziliensis LbrM.32.2230   cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative
Leishmania donovani LdBPK_322150.1   cop-coated vesicle membrane protein p24 precursor, putative
Leishmania infantum LinJ.32.2150   cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative
Leishmania major LmjF.32.2020   cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative
Leishmania mexicana LmxM.31.2020   cop-coated vesicle membrane protein p24 precursor, putative,ER--golgi transport protein p24, putative
Loa Loa (eye worm) LOAG_01105   SEL-9 protein
Mus musculus ENSMUSG00000029390   transmembrane emp24 domain trafficking protein 2
Mus musculus 100862175   predicted gene, 21540
Oryza sativa 4334079   Os03g0744800
Plasmodium berghei PBANKA_1413000   cop-coated vesicle membrane protein p24 precursor, putative
Plasmodium falciparum PF3D7_1314500   cop-coated vesicle membrane protein p24 precursor, putative
Plasmodium knowlesi PKNH_1415100   cop-coated vesicle membrane protein p24 precursor, putative
Plasmodium vivax PVX_122545   cop-coated vesicle membrane protein p24 precursor, putative
Plasmodium yoelii PY00476   hypothetical protein
Saccharomyces cerevisiae YGL200C   Emp24p
Saccharomyces cerevisiae YDL018C   Erp3p
Schistosoma japonicum Sjp_0036440   Transmembrane emp24 domain-containing protein 2 precursor, putative
Schistosoma mansoni Smp_046250   copii-coated vesicle membrane protein P24
Schmidtea mediterranea mk4.004702.00   CHOp24
Schmidtea mediterranea mk4.002151.02   CHOp24
Schmidtea mediterranea mk4.001928.02   EMP24
Schmidtea mediterranea mk4.001629.04   Suppressor/enhancer of lin-12 protein 9
Trypanosoma brucei gambiense Tbg972.11.17110   cytosolic coat protein, putative
Trypanosoma brucei Tb927.11.15230   cytosolic coat protein, putative
Trypanosoma congolense TcIL3000.11.15380   cytosolic coat protein, putative
Trypanosoma cruzi TcCLB.511711.90   cop-coated vesicle membrane protein p24 precursor, putative
Trypanosoma cruzi TcCLB.503987.10   cop-coated vesicle membrane protein p24 precursor, putative
Theileria parva TP01_1195   cop-coated vesicle membrane protein p24 precursor, putative

Essentiality

PF3D7_1314500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.6880 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.6880 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.6880 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.6880 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W02D7.7 Caenorhabditis elegans larval arrest wormbase
CELE_W02D7.7 Caenorhabditis elegans slow growth wormbase
PBANKA_1413000 Plasmodium berghei Dispensable plasmo
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1314500 (Plasmodium falciparum), cop-coated vesicle membrane protein p24 precursor, putative
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