Detailed view for LmjF.19.0970

Basic information

TDR Targets ID: 20912
Leishmania major, peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.4348 | Length (AA): 202 | MW (Da): 22833 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00254   FKBP-type peptidyl-prolyl cis-trans isomerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 188 1jvw (A) 33 192 39.00 0 1 1.36 -1.01
29 188 1jvw (A) 33 192 39.00 0 1 1.35578 -0.96
62 169 1r9h (A) 14 122 21.00 0 0.91 0.877353 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_183469)

Species Accession Gene Product
Leishmania braziliensis LbrM.19.1230   peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
Leishmania donovani LdBPK_190920.1   peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
Leishmania infantum LinJ.19.0920   peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
Leishmania major LmjF.19.0970   peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
Leishmania mexicana LmxM.19.0970   peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus FK506-binding protein 1A 108 aa 25.7% 105 aa Compounds References
Gallus gallus FK506 binding protein 12 108 aa 24.8% 105 aa Compounds References
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 196 aa 37.4% 187 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

5 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.19.0970 (Leishmania major), peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative
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