Detailed view for LmjF.35.2010

Basic information

TDR Targets ID: 21080
Leishmania major, 40S ribosomal protein S6, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 11.9856 | Length (AA): 249 | MW (Da): 28304 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01092   Ribosomal protein S6e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Biosynthesis of secondary metabolites (KEGG)
Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 239 4kzy (G) 1 237 44.00 0 1 1.40194 0.75
149 248 2gl2 (A) 6 109 12.00 0.18 0.01 0.510706 -0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126964)

Species Accession Gene Product
Arabidopsis thaliana AT5G10360   40S ribosomal protein S6-2
Babesia bovis BBOV_III004660   40S ribosomal protein S6, putative
Brugia malayi Bm1_50740   40S ribosomal protein S6
Candida albicans CaO19.12130   likely cytosolic ribosomal protein similar to S. cerevisiae RPS6A (YPL090C) and RPS6B (YBR181C) small subunit protein S6
Candida albicans CaO19.4660   likely cytosolic ribosomal protein similar to S. cerevisiae RPS6A (YPL090C) and RPS6B (YBR181C) small subunit protein S6
Caenorhabditis elegans CELE_Y71A12B.1   Protein RPS-6, isoform C
Cryptosporidium hominis Chro.20458   ribosomal protein S6e
Cryptosporidium parvum cgd2_4260   40S ribosomal protein S6
Dictyostelium discoideum DDB_G0280823   40S ribosomal protein S6
Drosophila melanogaster Dmel_CG10944   Ribosomal protein S6
Echinococcus granulosus EgrG_000877900   40S ribosomal protein S6
Entamoeba histolytica EHI_013890   40S ribosomal protein S6, putative
Entamoeba histolytica EHI_199990   40S ribosomal protein S6, putative
Entamoeba histolytica EHI_124190   40S ribosomal protein S6, putative
Entamoeba histolytica EHI_000590   40S ribosomal protein S6, putative
Echinococcus multilocularis EmuJ_000877900   40S ribosomal protein S6
Giardia lamblia GL50803_14620   Ribosomal protein S6
Homo sapiens ENSG00000137154   ribosomal protein S6
Leishmania braziliensis LbrM.33.0840   40S ribosomal protein S6, putative
Leishmania braziliensis LbrM.34.1920   40S ribosomal protein S6, putative
Leishmania infantum LinJ.35.2000   40S ribosomal protein S6, putative
Leishmania infantum LinJ.21.2150   40S ribosomal protein S6, putative
Leishmania major LmjF.21.1780   40S ribosomal protein S6, putative
Leishmania major LmjF.35.2010   40S ribosomal protein S6, putative
Leishmania mexicana LmxM.21.1780   40S ribosomal protein S6, putative
Leishmania mexicana LmxM.34.2010   40S ribosomal protein S6, putative
Loa Loa (eye worm) LOAG_02331   40S ribosomal protein S6
Mus musculus 20104   ribosomal protein S6
Neospora caninum NCLIV_012120   hypothetical protein
Oryza sativa 4343945   Os07g0622100
Oryza sativa 4333016   Os03g0390000
Plasmodium berghei PBANKA_1355100   40S ribosomal protein S6, putative
Plasmodium falciparum PF3D7_1342000   40S ribosomal protein S6
Plasmodium knowlesi PKNH_1259400   40S ribosomal protein S6, putative
Plasmodium vivax PVX_083000   40S ribosomal protein S6, putative
Plasmodium yoelii PY06397   Ribosomal protein S6e, putative
Saccharomyces cerevisiae YPL090C   ribosomal 40S subunit protein S6A
Saccharomyces cerevisiae YBR181C   ribosomal 40S subunit protein S6B
Schistosoma japonicum Sjp_0074090   ko:K02991 small subunit ribosomal protein S6e, putative
Schistosoma mansoni Smp_053130   40S ribosomal protein S6
Schmidtea mediterranea mk4.002467.03   40S ribosomal protein S6
Trypanosoma brucei gambiense Tbg972.10.100   40S ribosomal protein S6, putative
Trypanosoma brucei gambiense Tbg972.9.9520   40S ribosomal protein S6, putative
Trypanosoma brucei Tb927.9.15360   40S ribosomal protein S6, putative
Trypanosoma brucei Tb927.10.190   40S ribosomal protein S6, putative
Trypanosoma congolense TcIL3000_10_60   40S ribosomal protein S6, putative
Trypanosoma congolense TcIL3000_9_6460   40S ribosomal protein S6, putative
Trypanosoma cruzi TcCLB.510769.49   40S ribosomal protein S6, putative
Trypanosoma cruzi TcCLB.506241.170   40S ribosomal protein S6, putative
Toxoplasma gondii TGME49_210690   ribosomal protein RPS6
Theileria parva TP02_0487   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_487470   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_282960   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_033590   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_370550   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_462810   40S ribosomal protein S6, putative
Trichomonas vaginalis TVAG_486930   40S ribosomal protein S6, putative

Essentiality

LmjF.35.2010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.190 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.190 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.190 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.190 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb09.244.2630 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.244.2630 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.244.2630 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.244.2630 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y71A12B.1 Caenorhabditis elegans larval lethal wormbase
CELE_Y71A12B.1 Caenorhabditis elegans slow growth wormbase
CELE_Y71A12B.1 Caenorhabditis elegans sterile wormbase
PBANKA_1355100 Plasmodium berghei Essential plasmo
TGME49_210690 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.35.2010 (Leishmania major), 40S ribosomal protein S6, putative
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