Detailed view for PF3D7_1321800

Basic information

TDR Targets ID: 2109
Plasmodium falciparum, protein transport protein SFT2, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.8908 | Length (AA): 259 | MW (Da): 29267 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04178   Got1/Sft2-like family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0016192   vesicle-mediated transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
104 244 3rvy (A) 1040 1144 33.00 0.75 0.05 0.266702 2.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, Oocyst, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128885)

Species Accession Gene Product
Arabidopsis thaliana AT5G56020   Got1/Sft2-like vescicle transport protein
Arabidopsis thaliana AT4G26550   Got1/Sft2-like vescicle transport protein
Babesia bovis BBOV_III001610   SFT-2 like family protein
Candida albicans CaO19.2342   one of two genes similar to S. cerevisiae SFT2 (YBL102W) involved in Golgi to endosome transport
Candida albicans CaO19.9878   one of two genes similar to S. cerevisiae SFT2 (YBL102W) involved in Golgi to endosome transport
Candida albicans CaO19.10694   one of two genes similar to S. cerevisiae SFT2 (YBL102W) involved in Golgi to endosome transport
Candida albicans CaO19.3184   one of two genes similar to S. cerevisiae SFT2 (YBL102W) involved in Golgi to endosome transport
Caenorhabditis elegans CELE_C18E9.10   Protein C18E9.10
Cryptosporidium hominis Chro.60084   hypothetical protein
Cryptosporidium parvum cgd6_630   conserved hypothetical protein
Dictyostelium discoideum DDB_G0290341   hypothetical protein
Drosophila melanogaster Dmel_CG33635   CG33635 gene product from transcript CG33635-RA
Echinococcus granulosus EgrG_000896200   SFT2
Echinococcus multilocularis EmuJ_000896200   SFT2
Homo sapiens 84826   SFT2 domain containing 3
Loa Loa (eye worm) LOAG_10629   hypothetical protein
Mus musculus ENSMUSG00000044982   SFT2 domain containing 3
Neospora caninum NCLIV_010970   hypothetical protein
Oryza sativa 4340821   Os06g0300300
Oryza sativa 4341495   Os06g0608600
Onchocerca volvulus OVOC10116  
Plasmodium berghei PBANKA_1337200   protein transport protein SFT2, putative
Plasmodium falciparum PF3D7_1321800   protein transport protein SFT2, putative
Plasmodium knowlesi PKNH_1207000   protein transport protein SFT2, putative
Plasmodium vivax PVX_116780   protein transport protein SFT2, putative
Plasmodium yoelii PY06857   hypothetical protein
Saccharomyces cerevisiae YBL102W   Sft2p
Schistosoma japonicum Sjp_0209880   Protein transport protein SFT2, putative
Schistosoma mansoni Smp_067780   hypothetical protein
Schmidtea mediterranea mk4.004710.04  
Schmidtea mediterranea mk4.008996.00  
Trypanosoma brucei gambiense Tbg972.3.2920   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.2850   Got1/Sft2-like family, putative
Trypanosoma congolense TcIL3000_3_1750   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508153.810   Got1/Sft2-like family, putative
Toxoplasma gondii TGME49_318570   SFT2 family protein
Theileria parva TP03_0679   hypothetical protein, conserved
Trichomonas vaginalis TVAG_290870   conserved hypothetical protein

Essentiality

PF3D7_1321800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2850 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.2850 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.2850 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.2850 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C18E9.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_C18E9.10 Caenorhabditis elegans larval arrest wormbase
CELE_C18E9.10 Caenorhabditis elegans slow growth wormbase
CELE_C18E9.10 Caenorhabditis elegans sterile wormbase
YBL102W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1337200 Plasmodium berghei Dispensable plasmo
TGME49_318570 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1321800 (Plasmodium falciparum), protein transport protein SFT2, putative
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